ChemicalBook > CAS DataBase List > 4-Hydroxycinnamic acid

4-Hydroxycinnamic acid

Product Name
4-Hydroxycinnamic acid
CAS No.
7400-08-0
Chemical Name
4-Hydroxycinnamic acid
Synonyms
4-Hydroxycinnamic acid;4-Hydroxycinnamic acid;P-HYDROXYCINNAMIC ACID;TRANS-4-COUMARIC ACID;TRANS-P-COUMARIC ACID;PHCA;P-CUMARIC ACID;TRANS-P-CUMARIC ACID;4-hydroxylcinnamic acid;3-(4-HYDROXYPHENYL)ACRYLIC ACID
CBNumber
CB9164396
Molecular Formula
C9H8O3
Formula Weight
164.16
MOL File
7400-08-0.mol
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4-Hydroxycinnamic acid Property

Melting point:
214 °C (dec.)(lit.)
Boiling point:
251.61°C (rough estimate)
Density 
1.2132 (rough estimate)
refractive index 
1.5380 (estimate)
storage temp. 
Store below +30°C.
solubility 
Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
4.65±0.10(Predicted)
color 
White to Off-White
Stability:
Light Sensitive
InChI
InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)
InChIKey
NGSWKAQJJWESNS-UHFFFAOYSA-N
SMILES
C(O)(=O)C=CC1=CC=C(O)C=C1
LogP
1.790
CAS DataBase Reference
7400-08-0(CAS DataBase Reference)
NIST Chemistry Reference
2-Propenoic acid, 3-(4-hydroxyphenyl)-(7400-08-0)
EPA Substance Registry System
p-Hydroxycinnamic acid (7400-08-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-36/37/39-22
WGK Germany 
2
RTECS 
GD9095000
HS Code 
2918 29 00
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.00237
Product name
4-Hydroxycinnamic acid
Purity
for synthesis
Packaging
10g
Price
$56.9
Updated
2024/03/01
Sigma-Aldrich
Product number
SAB1303797
Product name
ANTI-ACER3 (C-TERM) antibody produced in rabbit
Purity
IgG fraction of antiserum, buffered aqueous solution
Packaging
400μL
Price
$481
Updated
2024/03/01
Sigma-Aldrich
Product number
8.00237
Product name
4-Hydroxycinnamic acid
Purity
for synthesis
Packaging
50g
Price
$144
Updated
2024/03/01
Sigma-Aldrich
Product number
SAB4502315
Product name
Anti-PHCA antibody produced in rabbit
Purity
affinity isolated antibody
Packaging
100μG
Price
$434
Updated
2022/05/15
TRC
Product number
C755365
Product name
p-Coumaric acid
Packaging
250g
Price
$275
Updated
2021/12/16
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4-Hydroxycinnamic acid Chemical Properties,Usage,Production

Chemical Properties

Light yellow to beige crystalline powder with aroma, soluble in methanol, ethanol, DMSO and other organic solvents, derived from synthesis.

Uses

4-Hydroxycinnamic acid is the hydroxy derivative of Cinnamic Acid with antioxidant properties. It is a is a major component of lignocellulose. Studies suggest that 4-Hydroxycinnamic acid may reduce the risk of cancer by reducing the formation of carcinogenic nitrosamines. A recent study reports that 4-Hydroxycinnamic acid may act as a chemical castrator in bees by altering the epression of genes required for ovary development. This compound is common in pollen a major constituent of the worker bee diet, but it is not found in queen bees'royal jelly.

Application

p-Hydroxycinnamic acid is mainly used as an intermediate in the pharmaceutical and perfume industries. It can react with dimethyl sulfate to produce p-anisaldehyde, react with acetaldehyde to produce p-hydroxycinnamaldehyde, and further oxidize it to produce cinnamic acid. This product can be directly oxidized to produce 4-Hydroxybenzoic acid and reduction to produce 4-Hydroxybenzyl alcohol.

Definition

ChEBI: 4-coumaric acid is a coumaric acid in which the hydroxy substituent is located at C-4 of the phenyl ring. It has a role as a plant metabolite. It is a conjugate acid of a 4-coumarate.

Hazard

Moderately toxic.

Safety Profile

Moderarely toxic by intraperitoneal route. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and fumes. See also COUMARIN

4-Hydroxycinnamic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Hydroxycinnamic acid Suppliers

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View Lastest Price from 4-Hydroxycinnamic acid manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
p-Hydroxy-cinnamic acid 7400-08-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-28
Hebei Chuanghai Biotechnology Co,.LTD
Product
P-Hydroxycinnamic Acid 7400-08-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99.8%
Supply Ability
100tons
Release date
2024-08-20
Hebei Kingfiner Technology Development Co.Ltd
Product
4-Hydroxycinnamic acid 7400-08-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000kg
Release date
2024-05-29

7400-08-0, 4-Hydroxycinnamic acidRelated Search:

p-Coumaric acid Methyl 4-hydroxyphenylacetate Methyl 3-(4-hydroxyphenyl)propionate Sodium methylparaben Sodium propylparaben 4-Hydroxybenzoic acid 4-Nitrophenylacetic acid 3-(4-Hydroxyphenyl)propionic acid 4-Nitrobenzyl alcohol 4-Bromomethylbenzoic acid 4'-Hydroxyacetophenone 4-Formylbenzoic acid 4-Nitrobenzaldehyde 4-Ethoxybenzoic acid 3,5-DI-T-BUTYL-4-HYDROXYCINNAMIC ACID,3,5-DI-TERT-BUTYL-4-HYDROXYCINNAMIC ACID 4-Hydroxyphenylpyruvic acid HYDROXYCINNAMIC ACID Ferulic Acid

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  • 4-Hydroxycinnamic acid
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  • 4-HYDROXYCINNAMIC ACID FOR SYNTHESIS
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  • Esmolol Impurity 51