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(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid

Product Name
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid
CAS No.
17257-71-5
Chemical Name
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid
Synonyms
(-)-MTPA;(S)-(-)-MPTA;MOSHERS ACID;(-)-MOSHER'S ACID;(S)-(-)-Mosheracid;(S)-(-)-MOSHER'S ACID;(-)-MTPA, Moshers acid;(-)-Moshers acid~(-)-MTPA;(S)-(-)-MTPA,(S)-(-)-Mosher'sacid;(-)-A-METHOXY-A-TRIFLUOROMETHYLPHENYLACETIC ACID
CBNumber
CB9171585
Molecular Formula
C10H9F3O3
Formula Weight
234.17
MOL File
17257-71-5.mol
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(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Property

Melting point:
46-49 °C(lit.)
Boiling point:
95-97 °C0.05 mm Hg(lit.)
alpha 
D24 -71.8± 0.6° (c = 3.28 in CH3OH)
Density 
1.303 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.474(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
Readily soluble in hexane, ether, THF, CH2Cl2, benzene.
form 
Viscous Liquid or Low Melting Solid
pka
1.47±0.10(Predicted)
Specific Gravity
1.303
color 
Clear colorless or white
optical activity
[α]20/D 73±1°, c = 2% in methanol
Sensitive 
Hygroscopic
Merck 
14,6280
BRN 
3591561
CAS DataBase Reference
17257-71-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
F 
3-10
Hazard Note 
Irritant/Keep Cold
HazardClass 
IRRITANT, HYGROSCOPIC, KEEP COLD
HS Code 
29189900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
318035
Product name
(S)-(?)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid
Purity
≥99%
Packaging
250mg
Price
$80.1
Updated
2024/03/01
Sigma-Aldrich
Product number
318035
Product name
(S)-(?)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid
Purity
≥99%
Packaging
1g
Price
$170
Updated
2024/03/01
Sigma-Aldrich
Product number
65369
Product name
(S)-(−)-α-Methoxy-α-trifluoromethylphenylacetic acid
Purity
for chiral derivatization, LiChropur?, ≥99.0%
Packaging
250mg
Price
$162
Updated
2022/05/15
TCI Chemical
Product number
M0832
Product name
(S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic Acid [Optical Resolving]
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$187
Updated
2024/03/01
TCI Chemical
Product number
M0832
Product name
(S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic Acid [Optical Resolving]
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$693
Updated
2024/03/01
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(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Chemical Properties,Usage,Production

Chemical Properties

clear colorless viscous liquid

Uses

(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid is used as a chiral derivatizing agent, it reacts with an alcohol or amine of unknown stereochemistry to form an ester or amide. The absolute configuration of the ester or amide is then determined by proton and/or 19F NMR spectroscopy.

General Description

(S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid is commonly used as a derivatizing agent in Mosher ester analysis and Mosher amide analysis, which are NMR-based methods for determining the absolute configuration of the chiral carbon center in secondary alcohols and amines, respectively.

Purification Methods

A likely impurity is phenylethylamine from the resolution. Dissolve the acid in Et2O/*benzene (3:1), wash with 0.5N H2SO4, then water, dry over magnesium sulfate, filter, evaporate and distil it. [Dale et al. J Org Chem 34 2543 1969, J Am Chem Soc 75 512 1973.]

(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Suppliers

Americas 1 Belgium 3 China 72 Europe 1 France 2 Germany 6 India 7 Japan 4 Switzerland 2 The Netherlands 2 United Kingdom 14 United States 35 Global 149
Matrix Fine Chemicals GmbH
Tel
--
Fax
--
Email
nfo@matrix-fine-chemicals.com
Country
Switzerland
ProdList
6968
Advantage
58
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid >=99% 17257-71-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

17257-71-5, (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acidRelated Search:

Citric acid 2-Methylphenylacetic acid 2,2-Diphenylacetic acid Ethyl 2-(Chlorosulfonyl)acetate (R)-(-)-alpha-Methoxyphenylacetic acid (Trifluoromethoxy)benzene α-Lipoic Acid Folic acid 2-Hydroxyphenylacetic acid Phenethyl phenylacetate METHOXYTRIMETHYLSILANE Ascoric Acid 3,3,3-TRIFLUOROLACTIC ACID (S)-(+)-2-HYDROXY-2-PHENYLPROPIONIC ACID (S)-(+)-alpha-Methoxyphenylacetic acid (S)-(+)-2-METHOXY-2-PHENYLETHANOL 2-Phenyl-1,2-propanediol 1-PHENYL-2,2,2-TRIFLUOROETHANOL

  • (S)-(-)-ɑ-Methoxy-ɑ-(trifluoromethyl)phenylacetic acid, 99%
  • (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Acid [Optical Resolving]
  • (-)-MTPA, Moshers acid
  • (S)-(-)-Mosheracid
  • (S)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoic acid
  • [S,(-)]-3,3,3-Trifluoro-2-methoxy-2-phenylpropionic acid
  • [S,(-)]-α-Trifluoromethyl-α-methoxyphenylacetic acid
  • [S,(-)]-β,β,β-Trifluoro-α-methoxyhydratropic acid
  • (S)-()-α-Methoxy-α-trifluoromethylphenylacetic acid,()-MTPA, Mosher’s acid
  • (2S)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoic acid 99% (99%ee)
  • (S)-3,3,3-Trifluoro-2-Methoxy-2-phenylpropanoic acid
  • (S)-(-)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetic Acid&nbsp
  • (S)-(-)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetic acid, 98% 250MG
  • (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid,98%
  • (S)-(-)-α-Methoxy-α-(trifluoroMethyl)phenylacetic Acid [Optical Resolving]
  • (S)-(-)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetic acid >=99%
  • (2S)-(-)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoic acid 99%
  • minus-A-methoxy-A-trifluoro-methyl*phenylacetic A
  • (S)-(-)-A-METHOXY-A-(TRIFLUOROMETHYL) PH ENYLACETIC ACID, 99+% (99% EE/GLC)
  • MINUS-A-METHOXY-A-TRIFLUORO-METHYL*PHENY LACETIC ACI
  • (S)-(-)-A-METHOXY-A-(TRIFLUORO-ME-)-PH-A CETIC ACID, CHIRASELECT REAG (99+%EE)
  • (S)-(-)-1-Methoxy-1-(trifluoromethyl)phenylaceticacid(ee)
  • (S)-(-)-MTPA,(S)-(-)-Mosher'sacid
  • Benzeneacetic acid, .alpha.-methoxy-.alpha.-(trifluoromethyl)-, (.alpha.S)-
  • (s)-(-)-à-methoxy-à-(trifluoromethyl)phenylacetic acid
  • (S)-(-)-1-Methoxy-1-(trifluoromethyl)phenylacetic acid 99% (99%ee)
  • (S)-(-)-1-Methoxy-1-(trifluoromethyl)phenylacetic acid (99%ee)
  • (-)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ACID
  • (-)-A-METHOXY-A-TRIFLUOROMETHYLPHENYLACETIC ACID
  • (S)-(-)-MOSHER'S ACID
  • (S)-(-)-MPTA
  • (S)-(-)-A-METHOXY-A-(TRIFLUOROMETHYL)PHENYLACETIC ACID
  • (S)-(-)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ACID
  • (S)-(-)-2-METHOXY-2-(TRIFLUOROMETHYL)PHENYLACETIC ACID
  • (S)-(-)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYLACETIC ACID
  • (-)-MOSHER'S ACID
  • MOSHERS ACID
  • (-)-MTPA
  • (S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid
  • (-)-Moshers acid~(-)-MTPA
  • (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
  • (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid
  • (S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylaceticAcid[OpticalResolving]&gt
  • Benzeneacetic acid, α-methoxy-α-(trifluoromethyl)-, (αS)-
  • (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic ac
  • (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
  • (S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic Acid [Optical Resolving]
  • (S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid
  • 17257-71-5
  • Asymmetric Synthesis
  • Derivatization Reagents
  • Chiral Resolving Reagents
  • Chiral Resolution Reagents
  • Analytical Chromatography Product Catalog
  • Chiral Derivatization
  • e.e. / Absolute Conefiguration Determination (NMR)
  • Enantiomer Excess & Absolute Conefiguration Determination
  • Analytical Chemistry