PD 166285
- Product Name
- PD 166285
- CAS No.
- 212391-63-4
- Chemical Name
- PD 166285
- Synonyms
- PD 166285;PD 166285 dihydrochloride;PD0166285 dihydrochloride;PD 166285 ISO 9001：2015 REACH;PD 166285 - CAS 212391-63-4 - Calbiochem;6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimi;6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylaMino)ethoxy]phenyl]aMino]-8-Methylpyrido[2,3-d]pyriMidin-7(8H)-one;6-(2,6-dichlorophenyl)-2-[4-[2-(diethylamino)ethoxy]anilino]-8-methylpyrido[2,3-d]pyrimidin-7-one,dihydrochloride;6-(2,6-Dichloro-phenyl)-2-[4-(2-diethylaMino-ethoxy)-phenylaMino]-8-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one hydrochloride;6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one Hydrochloride
- CBNumber
- CB91873310
- Molecular Formula
- C26H29Cl4N5O2
- Formula Weight
- 585.37
- MOL File
- 212391-63-4.mol
PD 166285 Property
- Melting point:
- 239-242?C
- storage temp.
- Desiccate at RT
- solubility
- DMSO, Methanol
- form
- Pale yellow solid
- color
- Yellow
- Stability:
- Hygroscopic
N-Bromosuccinimide Price
- Product number
- 513028
- Product name
- PD 166285 - CAS 212391-63-4 - Calbiochem<br />A cell-permeable, orally bioavailable, ATP-competitive, broad-spectrum tyrosine kinase inhibitor that suppresses angiogenesis both in vitro and in vivo.
- Packaging
- 5mg
- Price
- $216
- Updated
- 2024/03/01
- Product number
- 3785
- Product name
- PD166285dihydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 1
- Price
- $118
- Updated
- 2021/12/16
- Product number
- 019157
- Product name
- PD-166285
- Packaging
- 5mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- 286681
- Product name
- PD 166285
- Packaging
- 2mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- P217500
- Product name
- PD-166285
- Packaging
- 25mg
- Price
- $565
- Updated
- 2021/12/16
PD 166285 Chemical Properties,Usage,Production
Chemical Properties
Yellow Solid
Uses
A broad-spectrum receptor tyrosine kinase (RTK) inhibitor which shows anti-angiogenic activity and anti-tumor efficacy in combination with photodynamic therapy (PDT).
General Description
A cell-permeable, orally bioavailable, ATP-competitive, broad-spectrum tyrosine kinase inhibitor (IC50 against against c-Src, Wee1, FGFR-1, Myt1, EGFR, and PDGFRβ = 8.4, 24, 39.3, 72, 87.5 and 98.3 nM, respectively) that suppresses angiogenesis both in vitro (max inhibition dose at 100 nM in HUVEC microcapillary formation assays) and in vivo (max inhibition achieved via 5 mg/kg p.o. in murine Matrigel plug angiogenesis assays), while exhibiting much reduced potency against Chk1, MAPK, and PKC (IC50 = 3.4, 5, and 22.7 μM, respectively) and little activity toward IRTK and Cdk4/D1 even at concentrations as high as 50 μM. Shown to effectively block PDGF-, EGF-, and bFGF-stimulated receptor phosphorylations (IC50 = 6.5, 1600, and 97.3 nM, respectively) and other cellular responses in rat aortic smooth muscle cells. Inhibition of cellular Wee1 activity by 500 nM PD 166285 in combination with 50 ng/ml nocodazole (Cat. No. 487928) treatment is also reported to result in a blockage of radiation-induced Cdc2 phosphorylation on Tyr15 and Thr14 in 7 human cancer cells and specifically demonstrated to sensatize PA-1 cultures to radiation-induced cell death in a p53-dependent manner.
Biological Activity
Potent inhibitor of the tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor β (PDGFR β ) (IC 50 values are 8.4, 39.3 and 98.3 nM respectively). Also inhibits the checkpoint kinases Wee1 and Myt1; abolishes Cdc2 phosphorylation in numerous tumor cell lines and abrogates the G 2 checkpoint.
storage
Desiccate at RT
PD 166285 Preparation Products And Raw materials
Raw materials
Preparation Products
PD 166285 Suppliers
View Lastest Price from PD 166285 manufacturers
- Product
- PD 166285 212391-63-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-04-30
- Product
- PD 166285 212391-63-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-13
- Product
- PD 166285 212391-63-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2019-12-26