ChemicalBook > CAS DataBase List > (S)-3-Hydroxypyrrolidine

(S)-3-Hydroxypyrrolidine

Product Name
(S)-3-Hydroxypyrrolidine
CAS No.
100243-39-8
Chemical Name
(S)-3-Hydroxypyrrolidine
Synonyms
(S)-PYRROLIDIN-3-OL;S-HP;(S)-3-PyrroL;(S)-3-PYRROLIDINOL;(+)-3-Pyrrolidinol;3-PYRROLIDINOL, (S);(3S)-3-Pyrrolidinol;(S)-Pyrrolidine-3-ol;(3S)-Pyrrolidin-3-ol;(3S)-Pyrrolidine-3-ol
CBNumber
CB9195781
Molecular Formula
C4H9NO
Formula Weight
87.12
MOL File
100243-39-8.mol
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(S)-3-Hydroxypyrrolidine Property

Melting point:
15°C
Boiling point:
108-110 °C (8 mmHg)
alpha 
-6.5 º (c=3.5% in MeOH)
Density 
1.078 g/mL at 20 °C (lit.)
refractive index 
n20/D 1.490
Flash point:
>110°C
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
14.91±0.20(Predicted)
form 
Liquid After Melting
color 
Clear light yellow to yellow
Specific Gravity
1.078
optical activity
[α]20/D 6.5±1.5°, c = 3.5% in methanol
Water Solubility 
Fully miscible in water.
Sensitive 
Air Sensitive & Hygroscopic
BRN 
4652606
CAS DataBase Reference
100243-39-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-40
Safety Statements 
26-37/39-36-22
WGK Germany 
3
F 
10-34
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
56437
Product name
(S)-3-Pyrrolidinol
Purity
≥97.0% (sum of enantiomers, GC)
Packaging
5ml
Price
$320.8
Updated
2024/03/01
Sigma-Aldrich
Product number
56437
Product name
(S)-3-Pyrrolidinol
Purity
≥97.0% (sum of enantiomers, GC)
Packaging
1ml
Price
$220
Updated
2023/06/20
TCI Chemical
Product number
P1667
Product name
(S)-3-Pyrrolidinol
Purity
>97.0%(GC)(T)
Packaging
1g
Price
$54
Updated
2024/03/01
TCI Chemical
Product number
P1667
Product name
(S)-3-Pyrrolidinol
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$149
Updated
2024/03/01
Alfa Aesar
Product number
L19498
Product name
(S)-(-)-3-Hydroxypyrrolidine, 99%, ee 99%
Packaging
1g
Price
$153.65
Updated
2024/03/01
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(S)-3-Hydroxypyrrolidine Chemical Properties,Usage,Production

Description

(S)-3-Hydroxypyrrolidine is a chiral organic compound that serves as an important building block in the synthesis of various pharmaceuticals and natural products. It is a four-membered heterocyclic amino alcohol, featuring a hydroxyl group and a stereogenic center. The 'S' prefix indicates the configuration at the stereocenter, which is crucial for its reactivity and biological activity. This compound is notable for its role as an intermediate in the synthesis of drugs, particularly those targeting the central nervous system. The enantiomeric purity of (S)-3-Hydroxypyrrolidine is often critical, as the 'R' and 'S' enantiomers can exhibit different pharmacological properties.

Chemical Properties

clear light yellow to yellow liquid after melting

Uses

(S)-(-)-3-Hydroxypyrrolidine is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.

Purification Methods

The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.]

(S)-3-Hydroxypyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-3-Hydroxypyrrolidine Suppliers

Americas 1 Belgium 2 Canada 2 China 213 Europe 2 France 2 Germany 9 India 9 Japan 5 South Korea 4 Switzerland 5 The Netherlands 1 United Kingdom 15 United States 42 Global 313
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View Lastest Price from (S)-3-Hydroxypyrrolidine manufacturers

Nanjing Fred Technology Co., Ltd
Product
(S)-3-Hydroxypyrrolidine 100243-39-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-26
Hebei Yanxi Chemical Co., Ltd.
Product
(S)-3-Hydroxypyrrolidine 100243-39-8
Price
US $50.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2023-09-19
Hebei Kingfiner Technology Development Co.Ltd
Product
(S) 3-hydroxypyrrolidine 100243-39-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000kg
Release date
2023-12-20

100243-39-8, (S)-3-Hydroxypyrrolidine Related Search:

N-Vinyl-2-pyrrolidone N-Methyl-2-pyrrolidone Pyrrolidine Polyvinylpyrrolidone 3-Pyrrolidinol METHYL-2-PYRROLIDONE (+/-)-exo-6-Hydroxytropinone cis-4-Hydroxy-L-proline SCOPOLAMINE N-OXIDE HYDROBROMIDE 2,5-DIDEOXY-2,5-IMINO-D-MANNITOL Scopine hydrochloride SWAINSONINE Scopolamine hydrobromide HYOSCINE HYDROCHLORIDE SCOPOLAMINE METHYL NITRATE (S)-1-Benzyl-3-pyrrolidinol trans-4-Hydroxy-D-proline SAXITOXIN

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  • Pyrrolidines
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  • Asymmetric Synthesis
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  • Simple Alcohols (Chiral)
  • Synthetic Organic Chemistry
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