ChemicalBook > CAS DataBase List > 1H-indazole-7-carboxylic acid
1H-indazole-7-carboxylic acid
- Product Name
- 1H-indazole-7-carboxylic acid
- CAS No.
- 677304-69-7
- Chemical Name
- 1H-indazole-7-carboxylic acid
- Synonyms
- 7-Carboxy-1H-indazole;CgH6N2O2;Niraparib Intermediate4;7-INDAZOLE CARBOXYLIC ACID;7-INDAZOLE CARBOXYLLIC ACID;1H-Indazole-7-carboxylic aid;1H-Indazol-7-carboxylic acid;1H-INDAZOLE-7-CARBOXYLIC ACID;7-(1H)Indazole carboxylic acid;677304-69-7
- CBNumber
- CB9197275
- Molecular Formula
- C8H6N2O2
- Formula Weight
- 162.15
- MOL File
- 677304-69-7.mol
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1H-indazole-7-carboxylic acid Property
- Melting point:
- ca 240℃
- Boiling point:
- 443.7±18.0 °C(Predicted)
- Density
- 1.506±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Crystalline Powder
- pka
- 3.71±0.10(Predicted)
- color
- White to yellow
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Safety
- HS Code
- 29339980
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- ANV00147
- Product name
- 1H-Indazole-7-carboxylic acid
- Purity
- AldrichCPR
- Packaging
- 1G
- Price
- $724
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- H32463
- Product name
- 1H-Indazole-7-carboxylic acid, 95%
- Packaging
- 1g
- Price
- $405.65
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- H32463
- Product name
- 1H-Indazole-7-carboxylic acid, 95%
- Packaging
- 250mg
- Price
- $164
- Updated
- 2023/06/20
TRC
- Product number
- H341003
- Product name
- 1H-indazole-7-carboxylicAcid
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
Frontier Specialty Chemicals
- Product number
- C11375
- Product name
- 1H-Indazole-7-carboxylicacid
- Purity
- 96%
- Packaging
- 1g
- Price
- $63
- Updated
- 2021/12/16
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1H-indazole-7-carboxylic acid Chemical Properties,Usage,Production
Uses
1H-indazole-7-carboxylic Acid is an inhibitor of nitric oxide synthases.
Preparation
Synthesis of 1H-indazole-7-carboxylic acid, H2L4: To 60 mL anhydrous toluene under a nitrogen atmosphere was added methyl-2-amino-3-methylbenzoate (1.8 g, 11 mmol) and KOAc (560 mg, 5.7 mmol), and the mixture heated to reflux, at which time acetic anhydride (3.2 mL, 34 mmol) was added and the mixture stirred at reflux for 10 min. Isoamyl nitrite (2.3 mL, 18 mmol) was added over 30 min and the mixture refluxed overnight. On cooling, the mixture was filtered and evaporated to dryness to give 1.6 g of a pale brown solid, which analysed for methyl 1H-indazole-7-carboxylate. This material was taken up in 40 mL THF, added to a solution of LiOH (5 g, 210 mmol) in 40 mL water, and heated at reflux for 48 h. On cooling, the mixture was concentrated on a rotary evaporator and the resulting aqueous phase filtered and adjusted to pH 4 with dilute HCl, to precipitate the product, which was filtered, washed with water and dried under vacuum. Yield 810 mg, 45%; mp 218–222 °C (decomp);
δH (500 MHz, d6-DMSO): 7.23 (t, 1H, J = 7.5 Hz, H4 ), 7.97 (dd, 1H, J = 7.5, 1.0 Hz, H3 ), 8.06 (dd, 1H, J = 7.8, 0.8 Hz, H5 ), 8.21 (s, 1H, H2 ), 13.1 (br s, 2H, H1 & H6 ); δc (125 MHz, d6-DMSO): 113.7, 120.1, 124.6, 126.5, 129.0, 134.3, 138.0, 167.0; HRMS-ESI m/z: found: 163.0503; C8H7N2O2 requires: 163.0502 [M + H+ ]; ˉνmax/cm?1 (KBr): 3316 s br, 1700 s, 1619 m, 1592 m, 1509 m, 1285 s, 1201 m, 1145 m, 1078 m, 1056 w, 943 m, 858 s, 745 s, 638 m, 601 m.
1H-indazole-7-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-indazole-7-carboxylic acid manufacturers
Nanjing Fred Technology Co., Ltd
- Product
- 1H-Indazole-7-carboxylic aid 677304-69-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-25
Shaanxi Dideu New Materials Co. Ltd
- Product
- 1H-indazole-7-carboxylic acid 677304-69-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2024-11-06
Hebei Weibang Biotechnology Co., Ltd
- Product
- 1H-indazole-7-carboxylic acid 677304-69-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-05
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