ChemicalBook > CAS DataBase List > FMOC-PRO-OL

FMOC-PRO-OL

Product Name: FMOC-PRO-OL
CAS No.: 148625-77-8
Chemical Name: FMOC-PRO-OL
Synonyms: FMOC-PRO-OL;FMOC-PROLINOL;FMOC-L-PRO-OL;FMOC-L-PROLINOL;N-FMOC-L-PROLINOL;FMOC-PRO-OL USP/EP/BP;N-ALPHA-FMOC-L-PROLINOL;Fmoc-L-prolinol≥ 99% (Assay);(S)-Boc-2-pyrrolidinemethanol;(S)-N-FMOC-2-PYRROLIDINEMETHANOL
CBNumber: CB9200940
Molecular Formula: C20H21NO3
Formula Weight: 323.39
MOL File: 148625-77-8.mol

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FMOC-PRO-OL Property

Melting point:: 90℃
Boiling point:: 504.6±23.0 °C(Predicted)
Density: 1.242±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 14.77±0.10(Predicted)
Appearance: White to off-white Solid
optical activity: -31.62° (C=0.010056 g/ml, CHCL3, 20°C, 589nm)
BRN: 8789847
CAS DataBase Reference: 148625-77-8(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 10

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F861028
Product name: Fmoc-l-prolinol
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: F861028
Product name: Fmoc-l-prolinol
Packaging: 1g
Price: $165
Updated: 2021/12/16

Usbiological

Product number: 276994
Product name: Fmoc-L-prolinol
Packaging: 1g
Price: $353
Updated: 2021/12/16

Iris Biotech GmbH

Product number: FAL1002
Product name: Fmoc-L-Prolinol
Packaging: 25g
Price: $432
Updated: 2021/12/16

Chem-Impex

Product number: 03218
Product name: Fmoc-L-prolinol,99%(Assay)
Purity: 99%(Assay)
Packaging: 25G
Price: $436.8
Updated: 2021/12/16

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FMOC-PRO-OL Chemical Properties,Usage,Production

Chemical Properties

White or off-white Powder

Uses

Fmoc-l-prolinol is a useful intermediate for organic synthesis.

Synthesis

82911-69-1

23356-96-9

148625-77-8

(1) Synthesis of Fmoc-L-prolinol (Compound 2): L-prolinol (Compound 1) (0.61 g, 6.0 mmol) was dissolved in 70 mL of deionized water to prepare an aqueous solution of L-prolinol. N-(9-Fluorenylmethoxycarbonyloxy)succinimide (Fmoc-OSu) (2.0 g, 6.0 mmol) was dissolved in 10 mL of tetrahydrofuran (THF). This THF solution was slowly added to the aqueous L-prolinol solution and the reaction was stirred for 1 hour at room temperature. After completion of the reaction, the reaction mixture was separated into liquid and solid phases. These two portions were extracted with ethyl acetate, respectively, and the organic layers were combined. The combined organic layers were dried by adding anhydrous sodium sulfate to the combined organic layers. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=1:1, v/v) to afford compound 2 (1.4 g, 74% yield). The nuclear magnetic resonance hydrogen spectrum (1H-NMR) data of the compound were as follows: 1H-NMR (CDCl3): δ 7.77 (2H, d, J = 7.7 Hz, Ar-H), 7.60 (2H, d, J = 7.3 Hz, Ar-H), 7.40 (2H, t, J = 7.5 Hz, Ar-H), 7.31 (2H, t, J = 7.6 Hz Ar-H), 4.40-4.50 (2H, m, COOCH2), 4.22 (1H, t, J = 6.5 Hz, Ar-CH), 3.20-3.80 (5H, m, H-5, H-6), 1.75 (3H, m, H-3, H-4), 1.40 (1H, m, H-3).

References

[1] Patent: US9200278, 2015, B2. Location in patent: Page/Page column 39; 40; 41; 42

FMOC-PRO-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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FMOC-PRO-OL Suppliers

China 71 Germany 3 India 4 Japan 2 Switzerland 3 United Kingdom 3 United States 14 Global 100

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View Lastest Price from FMOC-PRO-OL manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-L-Pro-ol 148625-77-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-02-04

Sichuan Jiaying Lai Technology Co.,LTD

Product: Fmoc-L-Pro-ol 148625-77-8
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2019-07-23

148625-77-8, FMOC-PRO-OLRelated Search:

Fmoc-Pro-OH BOC-HYP(BZL)-OH Fmoc-Hyp(tBu)-OH FMOC-PRO-OL FMOC-OIC-OH FMOC-HYP(BZL)-OH FMOC-PRO-ONP FMOC-PRO-OPFP L-PROLINE-N-FMOC (15N) (2S,4S)-FMOC-4-PHENYL-PYRROLIDINE-2-CARBOXYLIC ACID FMOC-PRO-OSU (2S,5R)-FMOC-5-PHENYL-PYRROLIDINE-2-CARBOXYLIC ACID FMOC-L-PRO(4-OXO) FMOC-L-TRANSPRO(4-CHO) FMOC-PRO-2-CL-TRT RESIN FMOC-L-TRANSPRO(4-CN) N-FMOC-L-PROLINE, [3,4-3H] FMOC-L-TRANSPRO(4-CH2OH)

(S)-1-FMOC-2-PYRROLIDINEMETHANOL

(S)-N-FMOC-2-PYRROLIDINEMETHANOL

N-(9-FLUORENYLMETHOXYCARBONYL)-L-PROLINOL

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-PROLINOL

N-ALPHA-FMOC-L-PROLINOL

N-FMOC-L-PROLINOL

FMOC-L-PROLINOL

FMOC-L-PRO-OL

FMOC-PRO-OL

FMOC-PROLINOL

FMOC-(S)-2-(HYDROXYMETHYL)PYRROLIDINE

N-alpha-(9-Fluorenyloxycarbonyl)-L-prolinol,N-Fmoc-2S-pyrrolidinemethanol

N-ALPHA-(9-FLUOROENYLMETHYLOXYCARBONYL)-L-PROLINOL

NALPHA-9-Fluorenylmethoxycarbonyl-(S)-2-(hydroxymethyl)-pyrrolidine

N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-prolinol, (S)-Fmoc-2-(hydroxymethyl)pyrrolidine

(S)-2-(Hydroxymethyl)-1-pyrrolidinecarboxylic acid 9H-fluoren-9-ylmethyl ester

(S)-(9H-Fluoren-9-yl)Methyl 2-(hydroxyMethyl)pyrrolidine-1-carboxylate

1-Pyrrolidinecarboxylicacid, 2-(hydroxymethyl)-, 9H-fluoren-9-ylmethyl ester, (2S)-

(S)-Boc-2-pyrrolidinemethanol

Fmoc-L-prolinol≥ 99% (Assay)

(S)-1-Fmoc-2-(hydroxymethyl)-pyrrolidine

9H-fluoren-9-ylmethyl(2S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

FMOC-PRO-OL USP/EP/BP

148625-77-8

Amino Acid Derivatives

Amino Alcohols

Specialty Synthesis

Peptide Synthesis

Amino Acids