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FMOC-PRO-OL

Product Name
FMOC-PRO-OL
CAS No.
148625-77-8
Chemical Name
FMOC-PRO-OL
Synonyms
FMOC-PRO-OL;FMOC-PROLINOL;FMOC-L-PRO-OL;FMOC-L-PROLINOL;N-FMOC-L-PROLINOL;FMOC-PRO-OL USP/EP/BP;N-ALPHA-FMOC-L-PROLINOL;Fmoc-L-prolinol≥ 99% (Assay);(S)-Boc-2-pyrrolidinemethanol;(S)-N-FMOC-2-PYRROLIDINEMETHANOL
CBNumber
CB9200940
Molecular Formula
C20H21NO3
Formula Weight
323.39
MOL File
148625-77-8.mol
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FMOC-PRO-OL Property

Melting point:
90℃
Boiling point:
504.6±23.0 °C(Predicted)
Density 
1.242±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
pka
14.77±0.10(Predicted)
Appearance
White to off-white Solid
optical activity
-31.62° (C=0.010056 g/ml, CHCL3, 20°C, 589nm)
BRN 
8789847
CAS DataBase Reference
148625-77-8(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
F 
10
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
F861028
Product name
Fmoc-l-prolinol
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
F861028
Product name
Fmoc-l-prolinol
Packaging
1g
Price
$165
Updated
2021/12/16
Usbiological
Product number
276994
Product name
Fmoc-L-prolinol
Packaging
1g
Price
$353
Updated
2021/12/16
Iris Biotech GmbH
Product number
FAL1002
Product name
Fmoc-L-Prolinol
Packaging
25g
Price
$432
Updated
2021/12/16
Chem-Impex
Product number
03218
Product name
Fmoc-L-prolinol,99%(Assay)
Purity
99%(Assay)
Packaging
25G
Price
$436.8
Updated
2021/12/16
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FMOC-PRO-OL Chemical Properties,Usage,Production

Chemical Properties

White or off-white Powder

Uses

Fmoc-l-prolinol is a useful intermediate for organic synthesis.

Synthesis

82911-69-1

23356-96-9

148625-77-8

(1) Synthesis of Fmoc-L-prolinol (Compound 2): L-prolinol (Compound 1) (0.61 g, 6.0 mmol) was dissolved in 70 mL of deionized water to prepare an aqueous solution of L-prolinol. N-(9-Fluorenylmethoxycarbonyloxy)succinimide (Fmoc-OSu) (2.0 g, 6.0 mmol) was dissolved in 10 mL of tetrahydrofuran (THF). This THF solution was slowly added to the aqueous L-prolinol solution and the reaction was stirred for 1 hour at room temperature. After completion of the reaction, the reaction mixture was separated into liquid and solid phases. These two portions were extracted with ethyl acetate, respectively, and the organic layers were combined. The combined organic layers were dried by adding anhydrous sodium sulfate to the combined organic layers. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=1:1, v/v) to afford compound 2 (1.4 g, 74% yield). The nuclear magnetic resonance hydrogen spectrum (1H-NMR) data of the compound were as follows: 1H-NMR (CDCl3): δ 7.77 (2H, d, J = 7.7 Hz, Ar-H), 7.60 (2H, d, J = 7.3 Hz, Ar-H), 7.40 (2H, t, J = 7.5 Hz, Ar-H), 7.31 (2H, t, J = 7.6 Hz Ar-H), 4.40-4.50 (2H, m, COOCH2), 4.22 (1H, t, J = 6.5 Hz, Ar-CH), 3.20-3.80 (5H, m, H-5, H-6), 1.75 (3H, m, H-3, H-4), 1.40 (1H, m, H-3).

References

[1] Patent: US9200278, 2015, B2. Location in patent: Page/Page column 39; 40; 41; 42

FMOC-PRO-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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FMOC-PRO-OL Suppliers

China 71 Germany 3 India 4 Japan 2 Switzerland 3 United Kingdom 3 United States 14 Global 100
Achemica
Tel
--
Fax
--
Email
contact@achemica.com
Country
Switzerland
ProdList
6155
Advantage
50
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
Senn Chemicals AG
Tel
--
Fax
--
Email
swiss@sennchem.com
Country
Switzerland
ProdList
3143
Advantage
71
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View Lastest Price from FMOC-PRO-OL manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Fmoc-L-Pro-ol 148625-77-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-02-04
Sichuan Jiaying Lai Technology Co.,LTD
Product
Fmoc-L-Pro-ol 148625-77-8
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2019-07-23

148625-77-8, FMOC-PRO-OLRelated Search:

Fmoc-Pro-OH BOC-HYP(BZL)-OH Fmoc-Hyp(tBu)-OH FMOC-PRO-OL FMOC-OIC-OH FMOC-HYP(BZL)-OH FMOC-PRO-ONP FMOC-PRO-OPFP L-PROLINE-N-FMOC (15N) (2S,4S)-FMOC-4-PHENYL-PYRROLIDINE-2-CARBOXYLIC ACID FMOC-PRO-OSU (2S,5R)-FMOC-5-PHENYL-PYRROLIDINE-2-CARBOXYLIC ACID FMOC-L-PRO(4-OXO) FMOC-L-TRANSPRO(4-CHO) FMOC-PRO-2-CL-TRT RESIN FMOC-L-TRANSPRO(4-CN) N-FMOC-L-PROLINE, [3,4-3H] FMOC-L-TRANSPRO(4-CH2OH)

  • (S)-1-FMOC-2-PYRROLIDINEMETHANOL
  • (S)-N-FMOC-2-PYRROLIDINEMETHANOL
  • N-(9-FLUORENYLMETHOXYCARBONYL)-L-PROLINOL
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-PROLINOL
  • N-ALPHA-FMOC-L-PROLINOL
  • N-FMOC-L-PROLINOL
  • FMOC-L-PROLINOL
  • FMOC-L-PRO-OL
  • FMOC-PRO-OL
  • FMOC-PROLINOL
  • FMOC-(S)-2-(HYDROXYMETHYL)PYRROLIDINE
  • N-alpha-(9-Fluorenyloxycarbonyl)-L-prolinol,N-Fmoc-2S-pyrrolidinemethanol
  • N-ALPHA-(9-FLUOROENYLMETHYLOXYCARBONYL)-L-PROLINOL
  • NALPHA-9-Fluorenylmethoxycarbonyl-(S)-2-(hydroxymethyl)-pyrrolidine
  • N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-prolinol, (S)-Fmoc-2-(hydroxymethyl)pyrrolidine
  • (S)-2-(Hydroxymethyl)-1-pyrrolidinecarboxylic acid 9H-fluoren-9-ylmethyl ester
  • (S)-(9H-Fluoren-9-yl)Methyl 2-(hydroxyMethyl)pyrrolidine-1-carboxylate
  • 1-Pyrrolidinecarboxylicacid, 2-(hydroxymethyl)-, 9H-fluoren-9-ylmethyl ester, (2S)-
  • (S)-Boc-2-pyrrolidinemethanol
  • Fmoc-L-prolinol≥ 99% (Assay)
  • (S)-1-Fmoc-2-(hydroxymethyl)-pyrrolidine
  • 9H-fluoren-9-ylmethyl(2S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
  • FMOC-PRO-OL USP/EP/BP
  • 148625-77-8
  • Amino Acid Derivatives
  • Amino Alcohols
  • Specialty Synthesis
  • Peptide Synthesis
  • Amino Acids