3-Chloro-4-hydroxybenzaldehyde

Product Name: 3-Chloro-4-hydroxybenzaldehyde
CAS No.: 2420-16-8
Chemical Name: 3-Chloro-4-hydroxybenzaldehyde
Synonyms: AKOS B028967;TIMTEC-BB SBB005887;TIMTEC-BB SBB004014;3-CHLORO-4-HYROXYBENZALDEHYDE;3-CHLORO-4-HYDROXYBENZALDEHYDE;Benzaldehyde, 3-chloro-4-hydroxy-;3-Chloro-4-hydroxybenzaldehyde >3-Chloro-4-hydroxybenzaldehyde 98%;3-Chloro-4-hydroxybenzaldehyde, 98%,;3-Chloro-4-hydroxybenzaldehyde, 99+%
CBNumber: CB9203815
Molecular Formula: C7H5ClO2
Formula Weight: 156.57
MOL File: 2420-16-8.mol

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3-Chloro-4-hydroxybenzaldehyde Property

Melting point:: 133-137 °C (lit.)
Boiling point:: 150 °C / 14mmHg
Density: 1.2683 (rough estimate)
refractive index: 1.5812 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: 6.30±0.18(Predicted)
color: White to Light yellow to Light orange
Sensitive: Air Sensitive
InChI: InChI=1S/C7H5ClO2/c8-6-3-5(4-9)1-2-7(6)10/h1-4,10H
InChIKey: VGSOCYWCRMXQAB-UHFFFAOYSA-N
SMILES: C(=O)C1=CC=C(O)C(Cl)=C1
CAS DataBase Reference: 2420-16-8(CAS DataBase Reference)
NIST Chemistry Reference: 3-Chloro-4-hydroxybenzaldehyde(2420-16-8)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-43-41-37/38-22-20/21/22
Safety Statements: 26-37/39-36/37/39-36-37
WGK Germany: 3
Hazard Note: Irritant/Air Sensitive
HS Code: 29130000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 644188
Product name: 3-Chloro-4-hydroxybenzaldehyde
Purity: 97%
Packaging: 1g
Price: $34.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: 644188
Product name: 3-Chloro-4-hydroxybenzaldehyde
Purity: 97%
Packaging: 5g
Price: $142
Updated: 2025/07/31

TCI Chemical

Product number: C2183
Product name: 3-Chloro-4-hydroxybenzaldehyde
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $334
Updated: 2025/07/31

TCI Chemical

Product number: C2183
Product name: 3-Chloro-4-hydroxybenzaldehyde
Purity: >97.0%(GC)(T)
Packaging: 25g
Price: $1335
Updated: 2025/07/31

TRC

Product number: C585768
Product name: 3-Chloro-4-hydroxybenzaldehyde
Packaging: 50mg
Price: $60
Updated: 2021/12/16

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3-Chloro-4-hydroxybenzaldehyde Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

123-08-0

2420-16-8

The general procedure for the synthesis of 3-chloro-4-hydroxybenzaldehyde from 4-hydroxybenzaldehyde was as follows: N-chlorosuccinimide (1.1 g, 8.18 mmol) was added to a solution of 4-hydroxybenzaldehyde (1.0 g, 8.18 mmol) dissolved in 10 ml of chloroform. The reaction mixture was heated and stirred at 50°C for 15 hours. After completion of the reaction, it was cooled to room temperature and concentrated under reduced pressure to remove the solvent. The residue was dissolved in 25 ml of ethyl acetate, washed sequentially with water and saturated saline, and the organic phase was dried with anhydrous sodium sulfate. After filtration, the crude product was obtained by concentration under reduced pressure. The crude product was purified by silica gel column chromatography using 12% ethyl acetate in hexane solution as eluent to give 1.1 g (86% yield) of 3-chloro-4-hydroxybenzaldehyde.1H-NMR (400 MHz, CDCl3) δ (ppm): 9.840 (s, 1H), 7.898-7.894 (d, 1H, J = 1.6 Hz), 7.749- 7.724 (dd, 1H, J = 8.4Hz), 7.164-7.143 (d, 1H, J = 8.4Hz), 6.288 (s, 1H).

References

[1] Tetrahedron Letters, 1994, vol. 35, # 28, p. 5043 - 5046
[2] Patent: WO2010/127212, 2010, A1. Location in patent: Page/Page column 35
[3] Patent: WO2010/127208, 2010, A1. Location in patent: Page/Page column 55
[4] Tetrahedron Asymmetry, 1997, vol. 8, # 24, p. 4003 - 4006
[5] Synthetic Communications, 2012, vol. 42, # 24, p. 3655 - 3663,9

3-Chloro-4-hydroxybenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Chloro-4-hydroxybenzaldehyde Suppliers

Americas 1 Belgium 1 China 158 China Hong Kong 1 Europe 4 France 1 Germany 5 India 7 Japan 1 Switzerland 5 Ukraine 1 United Kingdom 17 United States 43 Global 245

TCI Chemicals (India) Pvt. Ltd.

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View Lastest Price from 3-Chloro-4-hydroxybenzaldehyde manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3-Chloro-4-hydroxybenzaldehyde 2420-16-8
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-15

Career Henan Chemical Co

Product: 3-Chloro-4-hydroxybenzaldehyde 2420-16-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 100KG
Release date: 2019-08-29

2420-16-8, 3-Chloro-4-hydroxybenzaldehydeRelated Search:

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Benzaldehyde, 3-chloro-4-hydroxy-

TIMTEC-BB SBB004014

TIMTEC-BB SBB005887

AKOS B028967

3-CHLORO-4-HYDROXYBENZALDEHYDE

3-CHLORO-4-HYROXYBENZALDEHYDE

3-Chloro-4-hydroxybenzaldehyde 98%

3-Chloro-4-hydroxybenzaldehyde, 99+%

3-Chloro-4-hydroxybenzaldehyde &gt

3-Chloro-4-hydroxybenzaldehyde, 98%,

2420-16-8

ClC6H3OHCHO

ALDEHYDE

Aldehydes

Building Blocks

C7

Carbonyl Compounds

Organic Building Blocks

Phenyls & Phenyl-Het

C7

Carbonyl Compounds

Aromatic Aldehydes & Derivatives (substituted)

Aldehydes

Phenyls & Phenyl-Het

Benzaldehyde

bc0001

API