ChemicalBook > CAS DataBase List > (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

Product Name
(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
CAS No.
132335-44-5
Chemical Name
(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
Synonyms
(s)-3-(dimethylamino)-1-(2-thienyl)-1-propanol;(S)-3-(Dimethylamino)-1-(2-thienyl)propan-1-ol;(S)-3-(dimethylamino)-1-(thiophen-2-yl)propan-1-ol;Duloxetine-18;Duloxetine Impurity49;Duloxetine intermediate AA;InterMediate of Duloxetine;Duloxetine Hydroxy IMpurity;Duloxetine S-Hydroxy Impurity;S-(-)-N,N-Dimethyl-3-hydroxy-3
CBNumber
CB9204180
Molecular Formula
C9H15NOS
Formula Weight
185.29
MOL File
132335-44-5.mol
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(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Property

Melting point:
78-80°C
Boiling point:
290°C
Density 
1.111
Flash point:
129°C
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
13.74±0.20(Predicted)
form 
Solid
color 
White
InChI
InChI=1/C9H15NOS/c1-10(2)6-5-8(11)9-4-3-7-12-9/h3-4,7-8,11H,5-6H2,1-2H3/t8-/s3
InChIKey
XWCNSHMHUZCRLN-SBYBRXNCNA-N
SMILES
C(N(C)C)C[C@H](O)C1SC=CC=1 |&1:5,r|
CAS DataBase Reference
132335-44-5(CAS DataBase Reference)
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D4010
Product name
(S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$22
Updated
2025/07/31
TCI Chemical
Product number
D4010
Product name
(S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$62
Updated
2025/07/31
TRC
Product number
H961825
Product name
(S)-1-β-Hydroxy-1-(2-thienyl)-3-dimethylaminopropane
Packaging
1g
Price
$50
Updated
2021/12/16
Activate Scientific
Product number
AS34101
Product name
(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
Purity
98+% ee
Packaging
5G
Price
$16
Updated
2021/12/16
Activate Scientific
Product number
AS34101
Product name
(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
Purity
98+% ee
Packaging
1g
Price
$18
Updated
2021/12/16
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(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A Duloxetine intermediate.

Synthesis

13196-35-5

132335-44-5

General procedure for the synthesis of (S)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)propylamine from N/A (Example 23): under argon protection, (R,R)-Cl2((R)-hexylBINAP)((R)-DAIPEN) (30.5 mg, 0.025 mmol), 2-propanol (100 ml), 1.0 M tert-butyl potassium oxychloride solution of 2-propanol (7.5 ml, 7.5 mmol) and 3-(N,N-dimethylamino)-1-(2-thienyl)-1-propanone (22.9 g, 0.125 mol) were added sequentially to a glass autoclave. After the reaction system was degassed several times and replaced with argon, hydrogen was introduced to a predetermined pressure to start the reaction. After stirring the reaction at 28°C for 6 hours, the reaction system was returned to normal temperature and pressure. The reaction solution was concentrated, heptane was added and the precipitated solid was filtered. The resulting solid was dried under reduced pressure to afford (S)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)propylamine 18.5 g in 80.0% yield. The optical purity of the product was determined by chiral column HPLC, and the result showed that the optical purity was 99% ee. Note: (R)-DAIPEN is (R)-1-isopropyl-2,2-bis(p-methoxyphenyl)ethylenediamine, and xylBINAP is 2,2'-bis(bis-3,5-dimethylphosphinodiphenyl)-1,1'-binaphthyl.

References

[1] Patent: EP1506965, 2005, A1. Location in patent: Page/Page column 35
[2] Angewandte Chemie (International ed. in English), 2004, vol. 43, # 21, p. 2816 - 2819
[3] Chemistry - A European Journal, 2011, vol. 17, # 28, p. 7760 - 7763
[4] Patent: US8426178, 2013, B2. Location in patent: Page/Page column
[5] Chemical Communications, 2015, vol. 51, # 61, p. 12328 - 12331

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Suppliers

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View Lastest Price from (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine 132335-44-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-18
Hebei Dangtong Import and export Co LTD
Product
132335-44-5 132335-44-5
Price
US $55.00-50.00/kg
Min. Order
10kg
Purity
99.99%
Supply Ability
100Tons
Release date
2023-03-03
Henan Bao Enluo International TradeCo.，LTD
Product
(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine 132335-44-5
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000tons
Release date
2023-07-04

132335-44-5, (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamineRelated Search:

Dimethyl disulfide ETHANE Dimethyl sulfoxide 3-Dimethylaminopropylamine Diisopropylamine Dimethyl sulfate Dimethyl ether Dimethyl carbonate Isopropylamine Tetrahydrothiophene Dimethyl fumarate 1-Propanol Cephalothin sodium Dacthal N,N-Dimethylformamide D/L-AMPHETAMINE HYDROCHLORIDE 3-(Dimethylamino)-1-(2-thienyl)-1-propanol (-)-2-[METHYLAMINO]-1-PHENYLPROPANE

  • (S)-1-HYDROXY-1-(2-THIENYL)-3-DIMETHYLAMINOPROPANE
  • (S)-1-BETA-HYDROXY-1-(2-THIENYL)-3-DIMETHYLAMINOPROPANE
  • (s)-3-(dimethylamino)-1-(2-thienyl)-1-propanol
  • (S)-(-)-N-DIMETHYL-3-HYDROXY-3-(2-THIENYL)-PROPANAMINE
  • S-(-)-N,N-DIMETHYL-3-HYDROXY-3-(2-THIENYL)PROPANAMINE
  • (S)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)-2-propanamine
  • Duloxetine intermediate AA
  • (S)-(-)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)propylamine
  • (S)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)-1-propylamine
  • S-(-)-N,N-Dimethyl-3-hydroxy-3
  • S-(-)-N,N-DIME-3-HY-3-(2-THIENYL)1PROPAMINE
  • (S)-3-(dimethylamino)-1-(thiophen-2-yl)propan-1-ol
  • S-(-)-N,N-Dime-3-Hy-3-(2-Thienyl)propamine
  • (1S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol
  • S-(-)-N,N-Dimethyl-3-hydroxy-(2-thienol)propanamine
  • (S)-(-)-N,N-DiMethyl-3-hydroxy-3-(2-thienyl)propan
  • (S)-N,N-DiMethyl-3-(2-thienyl)-3-hydroxypropanaMine
  • (S)-2-[3-(Dimethylamino)-1-hydroxypropyl]thiophene
  • InterMediate of Duloxetine
  • (S)-(-)-N,N-diMethyl-3-hydroxy-3-(2-thienyl)
  • Duloxetine Hydroxy IMpurity
  • (S)-(-)-alpha-methyl-1-naphthalenemethhanol
  • (<i>S</i>)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol
  • 2-Thiophenemethanol, a-[2-(dimethylamino)ethyl]-, (aS)-
  • (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propamine
  • (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol,99%e.e.
  • Duloxetine S-Hydroxy Impurity
  • S-(-)-N, N-dimethyl-3-hydroxy-3- (2-thiophene) propylamine
  • (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine in stock Factory
  • DUG-4 (S)-(-)-N,N-Dimethyl-3-Hydroxy-3-(2-Thienyl) Propanamine
  • Duloxetine-18
  • (1S)-3-(dimethylamino)-1-(thiophen-2-yl)propan-1-ol
  • (S)-3-(Dimethylamino)-1-(2-thienyl)propan-1-ol
  • (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol&gt
  • (S)-3-dimethylamino-1-(2-thiophene)-1-propanol
  • Duloxetine Dimethylaminopropanol Impurity
  • 2-Thiophenemethanol, α-[2-(dimethylamino)ethyl]-, (αS)-
  • (S)-(-)N, N-dimethyl-3-hydroxy 3-(2-thieyl)propanamine
  • (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine(For export only)
  • (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine ISO 9001：2015 REACH
  • (S)-1-β-Hydroxy-1-(2-thienyl)-3-dimethylaminopropane
  • S-(-)-N,N-dimethtl-3-hydroxy-3-(2-thienyl)propanamine
  • Duloxetine Dimethylaminopropanol Impurity/ Duloxetine Hydroxy Impurity
  • Duloxetine Impurity49
  • (S)-N,N-Dimethyl-3-(thiophen-2-yl)-3-hydroxy-propanamine
  • (s)-3-(dimethylamino)-1-(thiophen-2-yl)propan-1-Ol /mandelate salt
  • (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol(DMTP)
  • (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propana
  • (S)-(-)-3-(dimethylamino)-1-(2-thienyl)-1-propanol mandalate salt
  • (1S)-3-(dimethylamino)-1-(2-thienyl)propan-1-ol
  • N,N diethyl-3- hydroxy-3-(2- thienyl)- propanamine,Duloxetine Hydrochloride
  • (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(thiophen-2-yl)-propanamine
  • 132335-44-5
  • 1323235-44-5
  • C9H15NOS2
  • C9H15NOS
  • Heterocycles
  • Intermediates & Fine Chemicals