Cyclopentadecanolide

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Cyclopentadecanolide

Product Name: Cyclopentadecanolide
CAS No.: 106-02-5
Chemical Name: Cyclopentadecanolide
Synonyms: Exaltolide;PENTADECANOLIDE;OXACYCLOHEXADECAN-2-ONE;Exaltolide Total;ω-Pentadecalactone;PENTALIDE;Pentadecalactone;Pentadecan-15-olide;OMEGA-PENTADECALACTONE;Thibetolide
CBNumber: CB9207055
Molecular Formula: C15H28O2
Formula Weight: 240.38
MOL File: 106-02-5.mol

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Cyclopentadecanolide Property

Melting point:: 34-38 °C(lit.)
Boiling point:: 137 °C2 mm Hg(lit.)
Density: 0.918 g/mL at 25 °C(lit.)
vapor pressure: 0.085Pa at 25℃
FEMA: 2840 | OMEGA-PENTADECALACTONE
refractive index: 1.4700
Flash point:: >230 °F
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform, Ethyl Acetate, Methanol (Slightly)
form: Solid
color: White to Off-White
Odor: at 10.00 % in dipropylene glycol. musk animal powdery natural fruity
Odor Type: musk
Water Solubility: Soluble in alcohol, dipropylene glycol. Insoluble in water.
Merck: 14,3910
JECFA Number: 239
BRN: 143710
LogP: 5.79 at 25℃
CAS DataBase Reference: 106-02-5(CAS DataBase Reference)
NIST Chemistry Reference: Oxacyclohexadecan-2-one(106-02-5)
EPA Substance Registry System: Oxacyclohexadecan-2-one (106-02-5)

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Safety

Safety Statements: 24/25
WGK Germany: 1
RTECS: RN9775000
TSCA: Yes
HS Code: 29322090
Toxicity: Both the acute oral LD₅₀ value in rats and the acute dermal LD₅₀ value in rabbits exceeded 5 g/kg (Levenstein, 1974).

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: W284009
Product name: ω-Pentadecalactone
Purity: ≥98%,FG
Packaging: 1kg
Price: $322
Updated: 2024/03/01

Sigma-Aldrich

Product number: W284009
Product name: ω-Pentadecalactone
Purity: ≥98%,FG
Packaging: 5kg
Price: $806
Updated: 2024/03/01

Sigma-Aldrich

Product number: 419133
Product name: Pentadecanolide
Purity: 98%
Packaging: 25g
Price: $41.22
Updated: 2024/03/01

Sigma-Aldrich

Product number: 419133
Product name: Pentadecanolide
Purity: 98%
Packaging: 100g
Price: $103.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: W284009
Product name: ω-Pentadecalactone
Purity: ≥98%,FG
Packaging: 100g
Price: $95.8
Updated: 2023/01/07

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Cyclopentadecanolide Chemical Properties,Usage,Production

Chemical Properties

Cyclopentadecanolide occurs in small quantities in, for example, angelica root oil. It forms colorless crystals (mp 37–38°C) with a delicate, musk-like odor.

Chemical Properties

ω-Pentadecalactone has an extraordinarily persistent, musk-like odor.

Chemical Properties

Cyclopentadecanolide is a white crystalline low melting solid. melting at 36-37℃. to a colorless, viscous oil. B.P. 280℃. Delicately animal, musky and sweet, extremely tenacious odor of outstanding uniformity. Common use level in the perfume oil is about 0.1 to 0.4%.

Occurrence

Originally reported found in the essential oil from angelica roots.

Uses

Pentadecanolide is a monomer used to make PGA-co-pentadecalactone polymers to be used in the development of directly compressed prolonged release tablets of slightly soluble drugs such as ketoprofen.

Uses

Pentadecanolide may be used for the synthesis of poly(pentadecanolide) (PPDL) by Novozyme 435 catalyzed ring-opening polymerization. It may be employed as starting reagent for the synthesis of terminally-branched iso-fatty acids (iso-C₁₅-C₁₇).

Uses

As a fixative in perfumery.

Definition

ChEBI: Cyclopentadecanolide is a macrolide.

Application

Cyclopentadecanolide gives highly interesting effects when applied to certain flavors, e. g. alcoholic beverages, dentifrice flavors etc. There is very often a unanimous preference for the flavor that is properly treated with the hctone. Concentration in such flavors may be about 0.02 to 1.50 ppm calculated upon the finished consumer product. However, it should be kept in mind, that dentifrices are flavored at extremely high concentration (about 100) and it may therefore ghe an underestimated evaluation of the power of this Lactone, The most frequent abuse of Cyclopentadecanolide is that of over-dosage. It is also used extensively in Berry flavors, Liquor, Wine, Brandy, Fruit, Nut, Vanilla copositions, etc.

Preparation

The main industrial syntheses start from compounds produced from cyclododecatriene: either by ring expansion of cyclododecanone or by depolymerization of polyesters of 15-hydroxypentadecanoic acid (from 1,12-dodecanediol).

Aroma threshold values

Detection: 1 to 4 ppb

Taste threshold values

Taste characteristics at 75 ppm: vanilla bean, powdery helioropine, creamy and licorice.

Synthesis Reference(s)

Tetrahedron Letters, 34, p. 6107, 1993 DOI: 10.1016/S0040-4039(00)61741-0
The Journal of Organic Chemistry, 50, p. 2394, 1985 DOI: 10.1021/jo00213a044

General Description

Pentadecanolide is one of the major components, isolated from the root of Angelica archangelica L., species. It is a synthetic musk, which exists as a widespread contaminant in the environment.

Flammability and Explosibility

Non flammable

Trade name

Macrolide® (Symrise), Exaltolide®, Exaltolide®Total (Firmenich), Pentalide (Soda Aromatic).

Purification Methods

It has been recrystallised from MeOH (4 parts) at -15o. [Hundieck

Cyclopentadecanolide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cyclopentadecanolide manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Cyclopentadecanolide 106-02-5
Price: US $85.00-25.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-23

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Cyclopentadecanolide 106-02-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-09

Hebei Weibang Biotechnology Co., Ltd

Product: Cyclopentadecanolide 106-02-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-30

106-02-5, CyclopentadecanolideRelated Search:

Cyclopentadecanone Hyaluronic acid Ethyl 2-(Chlorosulfonyl)acetate ε-Caprolactone TRIOXSALEN Folic acid Spironolactone Citric acid Ascoric Acid Epothilone B Sagopilone alpha-Angelica lactone 15-HYDROXYPENTADECANOIC ACID heteratisine PHYSALIN D Epothilone A Cyclopentadecanolide BENZOYLHETERATISINE HYDROCHLORIDE

15-HYDROXYPENTADECANOIC ACID LACTONE

Cyclopentadecanolide~15-Hydroxypentadecanoic acid lactone~omega-Pentadecalactone

OMEGA-PENTADECALACTONE 98+%

exaltolid

CYCLOPENTADECENOLIDE

Pentadecan-15-olid

Exaltolide, Oxacyclohexadecan-2-one

CYCLOPENTADECANOLIDE (OXACYCLOHEXADECAN-2-ONE)

1-Oxa-2-cyclohexadecanone, 15-Hydroxypentadecanoic acid lactone, 15-Pentadecanolide, Pentadecanolide

1-Oxa-2-cyclohexadecanone, 15-Hydroxypentadecanoic acid lactone, 15-Pentadecanolide

Pentadecanolide,1-Oxa-2-cyclohexadecanone, 15-Hydroxypentadecanoic acid lactone, 15-Pentadecanolide

1-hydroxycyclopentadecan-1-ide

Cyclopentadecanolide, 98% 25GR

CYCLOPENTADECANOLIDE OR OXACYCLOHEXADECAN-2-ONE

exalltolide

Pentalide(R)

Exaltolide(R)

Cyclopentadecanolide,98%

16-oxabicyclo[13.2.0]heptadecan-17-one

PENTALIDE

PENTADECANOLIDE

OMEGA-PENTADECALACTONE

O-PENTADECALACTONE

OXACYCLOHEXADECAN-2-ONE

FEMA 2840

CYCLOPENTADECANOLIDE

1-OXA-2-CYCLOHEXADECANONE

1,15-Pentadecanolide

15-hydroxy-pentadecanoicacixi-lactone

2-Pentadecalone

Cyclopentadecanolactone

Exaltolide

Muskalactone

Muskolactone

Pentadecalactone

pentadecan-15-

Pentadecan-15-olide

Pentadecano-15-lactone

Pentadecanoic acid, 15-hydroxy-, xi-lactone

Pentadecanolactone

Thibetolide

15-PENTADECANOLACTONE

15-PENTADECANOLIDE

W-PENTADECALACTONE

Cyclopentadecanolide, FCC

Exaltolide Total

Macrolide supra

Pentadecanolide 98%

Pentadecanolide puriss., >=99.0% (GC)

Exaltolide (Firmenich)

Cyclopentadecanolide USP/EP/BP

16-oxacyclohexadecan-1-one

ω-Pentadecalactone

Water-Soluble PENTADECALACTONE , Nano-Liposomal PENTADECALACTONE

ater-Soluble PENTADECALACTONE , Nano-Liposomal PENTADECALACTONE

106-02-5

0106-02-05

C15H28O2