ChemicalBook > CAS DataBase List > Cyclopentadecanolide

Cyclopentadecanolide

Product Name
Cyclopentadecanolide
CAS No.
106-02-5
Chemical Name
Cyclopentadecanolide
Synonyms
Exaltolide;PENTADECANOLIDE;OXACYCLOHEXADECAN-2-ONE;Exaltolide Total;ω-Pentadecalactone;PENTALIDE;Pentadecalactone;Pentadecan-15-olide;OMEGA-PENTADECALACTONE;Thibetolide
CBNumber
CB9207055
Molecular Formula
C15H28O2
Formula Weight
240.38
MOL File
106-02-5.mol
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Cyclopentadecanolide Property

Melting point:
34-38 °C(lit.)
Boiling point:
137 °C2 mm Hg(lit.)
Density 
0.918 g/mL at 25 °C(lit.)
vapor pressure 
0.085Pa at 25℃
FEMA 
2840 | OMEGA-PENTADECALACTONE
refractive index 
1.4700
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform, Ethyl Acetate, Methanol (Slightly)
form 
Solid
color 
White to Off-White
Odor
at 10.00 % in dipropylene glycol. musk animal powdery natural fruity
Odor Type
musk
Water Solubility 
Soluble in alcohol, dipropylene glycol. Insoluble in water.
Merck 
14,3910
JECFA Number
239
BRN 
143710
LogP
5.79 at 25℃
CAS DataBase Reference
106-02-5(CAS DataBase Reference)
NIST Chemistry Reference
Oxacyclohexadecan-2-one(106-02-5)
EPA Substance Registry System
Oxacyclohexadecan-2-one (106-02-5)
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Safety

Safety Statements 
24/25
WGK Germany 
1
RTECS 
RN9775000
TSCA 
Yes
HS Code 
29322090
Toxicity
Both the acute oral LD50 value in rats and the acute dermal LD50 value in rabbits exceeded 5 g/kg (Levenstein, 1974).
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W284009
Product name
ω-Pentadecalactone
Purity
≥98%,FG
Packaging
1kg
Price
$322
Updated
2024/03/01
Sigma-Aldrich
Product number
W284009
Product name
ω-Pentadecalactone
Purity
≥98%,FG
Packaging
5kg
Price
$806
Updated
2024/03/01
Sigma-Aldrich
Product number
419133
Product name
Pentadecanolide
Purity
98%
Packaging
25g
Price
$41.22
Updated
2024/03/01
Sigma-Aldrich
Product number
419133
Product name
Pentadecanolide
Purity
98%
Packaging
100g
Price
$103.2
Updated
2024/03/01
Sigma-Aldrich
Product number
W284009
Product name
ω-Pentadecalactone
Purity
≥98%,FG
Packaging
100g
Price
$95.8
Updated
2023/01/07
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Cyclopentadecanolide Chemical Properties,Usage,Production

Chemical Properties

Cyclopentadecanolide occurs in small quantities in, for example, angelica root oil. It forms colorless crystals (mp 37–38°C) with a delicate, musk-like odor.

Chemical Properties

ω-Pentadecalactone has an extraordinarily persistent, musk-like odor.

Chemical Properties

Cyclopentadecanolide is a white crystalline low melting solid. melting at 36-37℃. to a colorless, viscous oil. B.P. 280℃. Delicately animal, musky and sweet, extremely tenacious odor of outstanding uniformity. Common use level in the perfume oil is about 0.1 to 0.4%.

Occurrence

Originally reported found in the essential oil from angelica roots.

Uses

Pentadecanolide is a monomer used to make PGA-co-pentadecalactone polymers to be used in the development of directly compressed prolonged release tablets of slightly soluble drugs such as ketoprofen.

Uses

Pentadecanolide may be used for the synthesis of poly(pentadecanolide) (PPDL) by Novozyme 435 catalyzed ring-opening polymerization. It may be employed as starting reagent for the synthesis of terminally-branched iso-fatty acids (iso-C15-C17).

Uses

As a fixative in perfumery.

Definition

ChEBI: Cyclopentadecanolide is a macrolide.

Application

Cyclopentadecanolide gives highly interesting effects when applied to certain flavors, e. g. alcoholic beverages, dentifrice flavors etc. There is very often a unanimous preference for the flavor that is properly treated with the hctone. Concentration in such flavors may be about 0.02 to 1.50 ppm calculated upon the finished consumer product. However, it should be kept in mind, that dentifrices are flavored at extremely high concentration (about 100) and it may therefore ghe an underestimated evaluation of the power of this Lactone, The most frequent abuse of Cyclopentadecanolide is that of over-dosage. It is also used extensively in Berry flavors, Liquor, Wine, Brandy, Fruit, Nut, Vanilla copositions, etc.

Preparation

The main industrial syntheses start from compounds produced from cyclododecatriene: either by ring expansion of cyclododecanone or by depolymerization of polyesters of 15-hydroxypentadecanoic acid (from 1,12-dodecanediol).

Aroma threshold values

Detection: 1 to 4 ppb

Taste threshold values

Taste characteristics at 75 ppm: vanilla bean, powdery helioropine, creamy and licorice.

Synthesis Reference(s)

Tetrahedron Letters, 34, p. 6107, 1993 DOI: 10.1016/S0040-4039(00)61741-0
The Journal of Organic Chemistry, 50, p. 2394, 1985 DOI: 10.1021/jo00213a044

General Description

Pentadecanolide is one of the major components, isolated from the root of Angelica archangelica L., species. It is a synthetic musk, which exists as a widespread contaminant in the environment.

Flammability and Explosibility

Non flammable

Trade name

Macrolide® (Symrise), Exaltolide®, Exaltolide®Total (Firmenich), Pentalide (Soda Aromatic).

Purification Methods

It has been recrystallised from MeOH (4 parts) at -15o. [Hundieck

Cyclopentadecanolide Preparation Products And Raw materials

Raw materials

Preparation Products

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Cyclopentadecanolide Suppliers

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View Lastest Price from Cyclopentadecanolide manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Cyclopentadecanolide 106-02-5
Price
US $85.00-25.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-23
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Cyclopentadecanolide 106-02-5
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-09
Hebei Weibang Biotechnology Co., Ltd
Product
Cyclopentadecanolide 106-02-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-30

106-02-5, CyclopentadecanolideRelated Search:

Cyclopentadecanone Hyaluronic acid Ethyl 2-(Chlorosulfonyl)acetate ε-Caprolactone TRIOXSALEN Folic acid Spironolactone Citric acid Ascoric Acid Epothilone B Sagopilone alpha-Angelica lactone 15-HYDROXYPENTADECANOIC ACID heteratisine PHYSALIN D Epothilone A Cyclopentadecanolide BENZOYLHETERATISINE HYDROCHLORIDE

  • 15-HYDROXYPENTADECANOIC ACID LACTONE
  • Cyclopentadecanolide~15-Hydroxypentadecanoic acid lactone~omega-Pentadecalactone
  • OMEGA-PENTADECALACTONE 98+%
  • exaltolid
  • CYCLOPENTADECENOLIDE
  • Pentadecan-15-olid
  • Exaltolide, Oxacyclohexadecan-2-one
  • CYCLOPENTADECANOLIDE (OXACYCLOHEXADECAN-2-ONE)
  • 1-Oxa-2-cyclohexadecanone, 15-Hydroxypentadecanoic acid lactone, 15-Pentadecanolide, Pentadecanolide
  • 1-Oxa-2-cyclohexadecanone, 15-Hydroxypentadecanoic acid lactone, 15-Pentadecanolide
  • Pentadecanolide,1-Oxa-2-cyclohexadecanone, 15-Hydroxypentadecanoic acid lactone, 15-Pentadecanolide
  • 1-hydroxycyclopentadecan-1-ide
  • Cyclopentadecanolide, 98% 25GR
  • CYCLOPENTADECANOLIDE OR OXACYCLOHEXADECAN-2-ONE
  • exalltolide
  • Pentalide(R)
  • Exaltolide(R)
  • Cyclopentadecanolide,98%
  • 16-oxabicyclo[13.2.0]heptadecan-17-one
  • PENTALIDE
  • PENTADECANOLIDE
  • OMEGA-PENTADECALACTONE
  • O-PENTADECALACTONE
  • OXACYCLOHEXADECAN-2-ONE
  • FEMA 2840
  • CYCLOPENTADECANOLIDE
  • 1-OXA-2-CYCLOHEXADECANONE
  • 1,15-Pentadecanolide
  • 15-hydroxy-pentadecanoicacixi-lactone
  • 2-Pentadecalone
  • Cyclopentadecanolactone
  • Exaltolide
  • Muskalactone
  • Muskolactone
  • Pentadecalactone
  • pentadecan-15-
  • Pentadecan-15-olide
  • Pentadecano-15-lactone
  • Pentadecanoic acid, 15-hydroxy-, xi-lactone
  • Pentadecanolactone
  • Thibetolide
  • 15-PENTADECANOLACTONE
  • 15-PENTADECANOLIDE
  • W-PENTADECALACTONE
  • Cyclopentadecanolide, FCC
  • Exaltolide Total
  • Macrolide supra
  • Pentadecanolide 98%
  • Pentadecanolide puriss., >=99.0% (GC)
  • Exaltolide (Firmenich)
  • Cyclopentadecanolide USP/EP/BP
  • 16-oxacyclohexadecan-1-one
  • ω-Pentadecalactone
  • Water-Soluble PENTADECALACTONE , Nano-Liposomal PENTADECALACTONE
  • ater-Soluble PENTADECALACTONE , Nano-Liposomal PENTADECALACTONE
  • 106-02-5
  • 0106-02-05
  • C15H28O2