ChemicalBook > CAS DataBase List > 2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester

2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester

Product Name
2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester
CAS No.
655235-65-7
Chemical Name
2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester
Synonyms
Methyl 3-chloro-5-(trifluoromethyl)picolinate;methyl 3-chloro-5-trifluoromethyl-2-pyridinecarboxylate;2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl este;3-Chloro-5-(trifluoromethyl)-2-pyridinecarboxylic acid methyl ester;2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester;Methyl 3-chloro-5-(trifluoromethyl)picolinate, 3-Chloro-2-(methoxycarbonyl)-5-(trifluoromethyl)pyridine
CBNumber
CB92079623
Molecular Formula
C8H5ClF3NO2
Formula Weight
239.58
MOL File
655235-65-7.mol
More
Less

2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester Property

Boiling point:
260℃
Density 
1.443
Flash point:
111℃
storage temp. 
Store at room temperature
pka
-3.33±0.10(Predicted)
Appearance
Colorless to light yellow Liquid
InChI
InChI=1S/C8H5ClF3NO2/c1-15-7(14)6-5(9)2-4(3-13-6)8(10,11)12/h2-3H,1H3
InChIKey
IBDYTWWXSCCQRL-UHFFFAOYSA-N
SMILES
C1(C(OC)=O)=NC=C(C(F)(F)F)C=C1Cl
More
Less

Safety

HS Code 
2933399990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

AK Scientific
Product number
Y9748
Product name
Methyl3-chloro-5-(trifluoromethyl)pyridine-2-carboxylate
Packaging
250mg
Price
$79
Updated
2021/12/16
AK Scientific
Product number
J95595
Product name
Methyl3-chloro-5-(trifluoromethyl)pyridine-2-carboxylate
Packaging
1g
Price
$130
Updated
2021/12/16
Apolloscientific
Product number
PC31856
Product name
Methyl3-chloro-5-(trifluoromethyl)pyridine-2-carboxylate
Packaging
250mg
Price
$140
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-7-Y1
Product name
Methyl 3-chloro-5-(trifluoromethyl)pyridine-2-carboxylate
Packaging
250mg
Price
$154
Updated
2021/12/16
AK Scientific
Product number
J95595
Product name
Methyl3-chloro-5-(trifluoromethyl)pyridine-2-carboxylate
Packaging
5g
Price
$450
Updated
2021/12/16
More
Less

2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester Chemical Properties,Usage,Production

Synthesis

67-56-1

338956-33-5

655235-65-7

GENERAL STEPS: Add heteroaromatic malononitrile (1.0 equiv., prepared according to Ref. 6) and the indicated solvent (1 mL / 0.12 mmol) to the reaction vessel. With stirring at room temperature, 4?molecular sieves were added. A solution of anhydrous m-CPBA (1.5 eq.) was prepared by dissolving it in the indicated solvent (1 mL / 0.22 mmol) and drying over molecular sieves (4?) for 10 min. The solution was added dropwise to the reaction mixture, followed by continued stirring for 10 min. After addition of nucleophilic reagent, the reaction mixture was kept stirring at room temperature. Upon completion of the reaction, the reaction was quenched with aqueous sodium thiosulfate and extracted with dichloromethane (CH2Cl2). The organic phases were combined, washed twice sequentially with saturated aqueous sodium bicarbonate (NaHCO3) and brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. Finally, purification was carried out by preparative high performance liquid chromatography (HPLC).

References

[1] Synlett, 2015, vol. 26, # 10, p. 1365 - 1370

2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester Suppliers

China 73 India 2 Slovakia 1 United Kingdom 3 United States 7 Global 86
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3295
Advantage
57
DKD Shijiazhuang Chemical Co., Ltd.
Tel
0311-0311-67790228 15531158659
Fax
66571013
Email
1257738041@qq.com
Country
China
ProdList
297
Advantage
62
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
CEG Chemical Science&Technology Co., Ltd.
Tel
Mobile:13665161512
Fax
+86-510-68873513
Country
China
ProdList
1785
Advantage
58
NINGBO INNO PHARMCHEM CO.,LTD.
Tel
86-574-27787657
Fax
86-574-27912196
Email
info@dearchem.com
Country
China
ProdList
4613
Advantage
58
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
Changzhou Tianrui Pharmaceutical Technology Co., Ltd.
Tel
0519-85386832 13382812559
Fax
0519-85386832
Email
sales@cztrchem.com
Country
China
ProdList
1185
Advantage
56
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Bellen Chemistry Co., Ltd.
Tel
010-60400365-8001 15910885229
Fax
010-60400361
Email
service@bellenchem.com
Country
China
ProdList
4514
Advantage
60
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
6059
Advantage
65
AgileBioChem Co., Ltd.
Tel
18055517827
Email
sales@agilebiochem.com
Country
China
ProdList
1003
Advantage
50
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai CR Corporation Limited
Tel
13062833949; 4006653949 4006653949
Fax
QQ: 2136646215
Email
fred.wen@crcorporation.cn
Country
China
ProdList
9755
Advantage
58
Nanijing m&m biotechnology Co. ,Ltd.
Tel
025-87782433 18021532344
Fax
025-87782433
Email
1345332203@qq.com
Country
China
ProdList
4134
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718; +8613336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29735
Advantage
60
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
16027
Advantage
58
Nanjing crow LuNing pharmaceutical technology co., LTD
Tel
13382066392
Country
CHINA
ProdList
4877
Advantage
58
Shanghai SPAR pharmaceutical technology co., LTD
Tel
021-000000
Email
admin@jingshipharmatech.com
Country
China
ProdList
9853
Advantage
58
Shanghai Moss Medicine Technology Co., Ltd.
Tel
+86-188369842 +86-15618151133
Fax
QQ188369842
Email
188369842@qq.com
Country
China
ProdList
1959
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
CR Corporation Limited
Tel
+8613062833949
Email
fred.wen@crcorporation.cn
Country
China
ProdList
8645
Advantage
58
ANHUI WITOP BIOTECH CO., LTD
Tel
+8615255079626
Email
eric@witopchemical.com
Country
China
ProdList
23541
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25356
Advantage
58
Blocksynth Pharmaceutical Technology Co.,Ltd
Tel
0086-19817745290; +8619817745290
Email
bd@blocksynth.com
Country
China
ProdList
5661
Advantage
58
Win-Win chemical CO., Limited
Tel
+86-0086-577-64498589 +86-15355981851
Fax
0086-577-56994596
Email
sales@win-winchemical.com
Country
China
ProdList
14359
Advantage
58
Rare Chemistry (Hong Kong) Co., Ltd.
Tel
Email
93634146@qq.com
Country
China
ProdList
831
Advantage
58
Hubei xin bonus chemical co. LTD
Tel
86-13657291602
Fax
027-59338440
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
22963
Advantage
58
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Email
sales@accelachem.com
Country
China
ProdList
10467
Advantage
58
Chengdu Feibo Pharm Technology Co., Ltd
Tel
+86 028-84641798 15982321820
Email
abby@arkpharm.com
Country
China
ProdList
10000
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39927
Advantage
58
Changzhou Yinghao Technology Development Co., Ltd
Tel
15151934985
Email
sales@yingsapharm.com
Country
China
ProdList
5181
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49975
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49312
Advantage
58
Nantong puyue biomedical Co., Ltd
Tel
0513-0513-0513-89158300 18014392889
Fax
0513-89158198
Email
sales@puyerbiopharma.com
Country
China
ProdList
4956
Advantage
58
Fuxin Pharmaceutical
Tel
+86-021-021-50872116 +8613122107989
Email
contact@fuxinpharm.com
Country
China
ProdList
10000
Advantage
58
Shanghai Jiuju Chemical Technology Co. LTD
Tel
021-54290889 18117093889
Email
1261932215@qq.com
Country
China
ProdList
399
Advantage
58
TCI (Shanghai) Chemical Trading Co., Ltd.
Tel
021-61109150
Fax
021-61105897
Email
sales@tcisct.com
Country
China
ProdList
29668
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
029-81124267 17392282731
Fax
029-88380327
Email
1073@dideu.com
Country
China
ProdList
9992
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
Suzhou Daolan Biomedical Technology Co., Ltd.
Tel
15952404857
Email
sales@dolanpharm.com
Country
China
ProdList
2919
Advantage
58
Bide Pharmatech Ltd.
Tel
400-6005915
Email
sales@picasso-e.com
Country
China
ProdList
39653
Advantage
58
Suzhou Xinrui Biotechnology Co., Ltd.
Tel
13401437572
Email
xinruibiotech01@163.com
Country
China
ProdList
2741
Advantage
58
Beijing InnoChem Science & Technology Co., Ltd.
Tel
15652467323
Email
sales@inno-chem.com.cn
Country
China
ProdList
8293
Advantage
58
Shanghai Lingfu Pharmaceutical Research Co. LTD
Tel
+86(21)5895 0110 19945755304
Email
sales@chemany.com
Country
China
ProdList
9984
Advantage
58
Chengdu Wuyuan Bioengineering Co., Ltd.
Tel
17358513851
Email
henry851@163.com
Country
China
ProdList
955
Advantage
58
Jiaxing Deyi Chemical Co., Ltd
Tel
0573-85866609 13588473046
Email
824930988@qq.com
Country
China
ProdList
7865
Advantage
58
More
Less

View Lastest Price from 2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester manufacturers

Career Henan Chemical Co
Product
2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester 655235-65-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-05-25

655235-65-7, 2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl esterRelated Search:

6-Trifluoromethyl-pyridine-2-carboxylic acid ethyl ester 2-(AMINOMETHYL)-3-CHLORO-5-(TRIFLUOROMETHYL)-PYRIDINE HYDROCHLORIDE 2-PYRIDINECARBOXYLIC ACID, 3-CHLORO-5-(TRIFLUOROMETHYL)-, ETHYL ESTER Methyl 3-chloropicolinate 5-(Trifluoromethyl)pyridine-2-carboxylic acid 3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXYLIC ACID 3-Chloropyridine-2-carboxylic acid 2-Pyridinecarboxylicacid,5-methyl-,methylester(9CI) 5-Trifluoromethyl-pyridine-2-carboxylic acid methyl ester (5-TRIFLUOROMETHYL-PYRIDIN-2-YL) METHANOL 5-METHYLPICOLINIC ACID 2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester

  • 2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester
  • 3-Chloro-5-(trifluoromethyl)-2-pyridinecarboxylic acid methyl ester
  • Methyl 3-chloro-5-(trifluoromethyl)picolinate, 3-Chloro-2-(methoxycarbonyl)-5-(trifluoromethyl)pyridine
  • Methyl 3-chloro-5-(trifluoromethyl)picolinate
  • methyl 3-chloro-5-trifluoromethyl-2-pyridinecarboxylate
  • 2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl este
  • 655235-65-7
  • Pyridines