2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester
- Product Name
- 2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester
- CAS No.
- 655235-65-7
- Chemical Name
- 2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester
- Synonyms
- Methyl 3-chloro-5-(trifluoromethyl)picolinate;methyl 3-chloro-5-trifluoromethyl-2-pyridinecarboxylate;2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl este;3-Chloro-5-(trifluoromethyl)-2-pyridinecarboxylic acid methyl ester;2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester;Methyl 3-chloro-5-(trifluoromethyl)picolinate, 3-Chloro-2-(methoxycarbonyl)-5-(trifluoromethyl)pyridine
- CBNumber
- CB92079623
- Molecular Formula
- C8H5ClF3NO2
- Formula Weight
- 239.58
- MOL File
- 655235-65-7.mol
2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester Property
- Boiling point:
- 260℃
- Density
- 1.443
- Flash point:
- 111℃
- storage temp.
- Store at room temperature
- pka
- -3.33±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C8H5ClF3NO2/c1-15-7(14)6-5(9)2-4(3-13-6)8(10,11)12/h2-3H,1H3
- InChIKey
- IBDYTWWXSCCQRL-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NC=C(C(F)(F)F)C=C1Cl
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- J95595
- Product name
- Methyl3-chloro-5-(trifluoromethyl)pyridine-2-carboxylate
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- PC31856
- Product name
- Methyl3-chloro-5-(trifluoromethyl)pyridine-2-carboxylate
- Packaging
- 250mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 4H23-7-Y1
- Product name
- Methyl 3-chloro-5-(trifluoromethyl)pyridine-2-carboxylate
- Packaging
- 250mg
- Price
- $154
- Updated
- 2021/12/16
- Product number
- Y9748
- Product name
- Methyl3-chloro-5-(trifluoromethyl)pyridine-2-carboxylate
- Packaging
- 250mg
- Price
- $79
- Updated
- 2021/12/16
- Product number
- J95595
- Product name
- Methyl3-chloro-5-(trifluoromethyl)pyridine-2-carboxylate
- Packaging
- 5g
- Price
- $450
- Updated
- 2021/12/16
2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester Chemical Properties,Usage,Production
Synthesis
67-56-1
338956-33-5
655235-65-7
GENERAL STEPS: Add heteroaromatic malononitrile (1.0 equiv., prepared according to Ref. 6) and the indicated solvent (1 mL / 0.12 mmol) to the reaction vessel. With stirring at room temperature, 4?molecular sieves were added. A solution of anhydrous m-CPBA (1.5 eq.) was prepared by dissolving it in the indicated solvent (1 mL / 0.22 mmol) and drying over molecular sieves (4?) for 10 min. The solution was added dropwise to the reaction mixture, followed by continued stirring for 10 min. After addition of nucleophilic reagent, the reaction mixture was kept stirring at room temperature. Upon completion of the reaction, the reaction was quenched with aqueous sodium thiosulfate and extracted with dichloromethane (CH2Cl2). The organic phases were combined, washed twice sequentially with saturated aqueous sodium bicarbonate (NaHCO3) and brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. Finally, purification was carried out by preparative high performance liquid chromatography (HPLC).
References
[1] Synlett, 2015, vol. 26, # 10, p. 1365 - 1370
2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester Suppliers
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View Lastest Price from 2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester manufacturers
- Product
- 2-Pyridinecarboxylic acid,3-chloro-5-(trifluoromethyl)-,methyl ester 655235-65-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-05-25