2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
- Product Name
- 2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
- CAS No.
- 871839-91-7
- Chemical Name
- 2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
- Synonyms
- 2-ISOPROXYPYRIDINE-5-BORONIC ACID PINACOLATE;2-Isoproxypyridine-4-boronic acid pinacol ester;2-isopropoxypyridine -5-boronic acid pinacolate;6-Isopropoxy-3-pyridylboronic Acid Pinacol Ester;2-isopropoxy-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;2-(propan-2-yloxy)-5-(tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine;2-(6-Isopropoxy-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE;2-propan-2-yloxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;Pyridine,2-(1-methylethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- CBNumber
- CB9213601
- Molecular Formula
- C14H22BNO3
- Formula Weight
- 263.14
- MOL File
- 871839-91-7.mol
2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Property
- Melting point:
- 72-75℃
- Boiling point:
- 347.6±27.0 °C(Predicted)
- Density
- 1.03±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- pka
- 4.23±0.24(Predicted)
- color
- White to Light yellow
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- I1099
- Product name
- 2-Isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
- Packaging
- 200MG
- Price
- $31
- Updated
- 2025/07/31
- Product number
- I1099
- Product name
- 2-Isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
- Packaging
- 1G
- Price
- $104
- Updated
- 2025/07/31
- Product number
- I918138
- Product name
- 2-Isopropoxypyridine-5-boronicacid,pinacolester
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- I918138
- Product name
- 2-Isopropoxypyridine-5-boronicacid,pinacolester
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 39886
- Product name
- 2-Isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine,98%(GC)
- Purity
- 98%(GC)
- Packaging
- 1G
- Price
- $98.56
- Updated
- 2021/12/16
2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Chemical Properties,Usage,Production
Uses
2-Isopropoxypyridine-5-boronic acid, pinacol ester
Synthesis
870521-31-6
73183-34-3
871839-91-7
Under nitrogen protection, to a stirred 1,4-dioxane (50 ml) of 5-bromo-2-isopropoxypyridine (5 g, 23.14 mmol), potassium acetate (5.68 g, 57.9 mmol), and 4,4,4,4,5,5,5,5-octamethyl-2,2'-bis(1,3,2-dioxaborolane) (8.81 g, 34.7 mmol) PdCl2(dppf)-DCM adduct (1.89 g, 2.314 mmol) was added to the suspension. The reaction mixture was heated at 110°C for 1 hour. After completion of the reaction, water was added to the mixture and extracted with ethyl acetate. The organic layers were combined, washed sequentially with water and brine, dried with Na2SO4 and concentrated under reduced pressure. The crude product was purified by column chromatography to afford 6-isopropoxypyridine-3-boronic acid pinacol ester as an oil (5 g, 82% yield).1H NMR (400 MHz, chloroform-d) δ 8.54 (s, 1H), 7.92 (d, J = 8.3Hz, 1H), 6.76-6.46 (m, 1H), 5.45-5.25 (m, 1H), and 1.37 (d, J = 2.4Hz, 6H), 1.28 (s, 12H).
References
[1] Patent: WO2017/37682, 2017, A1. Location in patent: Page/Page column 71; 72
[2] Patent: WO2005/123675, 2005, A1. Location in patent: Page/Page column 55
[3] Patent: WO2016/161160, 2016, A1. Location in patent: Paragraph 0160
[4] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 7, p. 761 - 767
[5] Patent: WO2009/105500, 2009, A1. Location in patent: Page/Page column 219-220
2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from 2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE manufacturers
- Product
- 2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 871839-91-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-19