ChemicalBook > CAS DataBase List > 4-(METHOXYCARBONYL)PHENYLBORONIC ACID

4-(METHOXYCARBONYL)PHENYLBORONIC ACID

Product Name: 4-(METHOXYCARBONYL)PHENYLBORONIC ACID
CAS No.: 99768-12-4
Chemical Name: 4-(METHOXYCARBONYL)PHENYLBORONIC ACID
Synonyms: 4-METHOXYCARBONYLPHENYLBORONIC ACID;METHYL 4-BORONOBENZOATE;Blueberry extract anthocyanin;AKOS BRN-0122;RARECHEM AH PB 0115;Methyl 4-boronobenzo;4-methoxybenzoborate;Methyl p-boronobenzoate;4-Methoxycarbonylphenylboronic;p-(Methoxycarbonyl)boronic acid
CBNumber: CB9216389
Molecular Formula: C8H9BO4
Formula Weight: 179.97
MOL File: 99768-12-4.mol

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4-(METHOXYCARBONYL)PHENYLBORONIC ACID Property

Melting point:: 197-200 °C (lit.)
Boiling point:: 345.8±44.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in methanol.
form: powder
pka: 7.69±0.10(Predicted)
color: white to off-white
InChI: InChI=1S/C8H9BO4/c1-13-8(10)6-2-4-7(5-3-6)9(11)12/h2-5,11-12H,1H3
InChIKey: PQCXFUXRTRESBD-UHFFFAOYSA-N
SMILES: C1=CC(C(OC)=O)=CC=C1B(O)O
CAS DataBase Reference: 99768-12-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26
WGK Germany: 3
TSCA: No
HazardClass: IRRITANT
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 594539
Product name: 4-Methoxycarbonylphenylboronic acid
Purity: ≥95%
Packaging: 1g
Price: $37.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: 594539
Product name: 4-Methoxycarbonylphenylboronic acid
Purity: ≥95%
Packaging: 5g
Price: $135
Updated: 2025/07/31

TCI Chemical

Product number: M1907
Product name: 4-(Methoxycarbonyl)phenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 1g
Price: $21
Updated: 2025/07/31

TCI Chemical

Product number: M1907
Product name: 4-(Methoxycarbonyl)phenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $36
Updated: 2025/07/31

TCI Chemical

Product number: M1907
Product name: 4-(Methoxycarbonyl)phenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 25g
Price: $109
Updated: 2025/07/31

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4-(METHOXYCARBONYL)PHENYLBORONIC ACID Chemical Properties,Usage,Production

Chemical Properties

White to light yellow crystal powde

Uses

suzuki reaction

Uses

4-(Methoxycarbonyl)phenylboronic Acid is used in the synthesis and evaluation of several organic compounds including that of 4-Cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate which is a potent inhibitor of intracellular NAAA activity. Also used in the design and synthesis of BMS-955176 which is a potent, orally active second generation HIV-1 maturation inhibitor.

Uses

4-(Methoxycarbonyl)phenylboronic Acid is a reagent used for• ;Tandem-type Pd(II)-catalyzed oxidative Heck reaction and intramolecular C-H amidation sequence1 • ;Copper-mediated ligandless aerobic fluoroalkylation of arylboronic acids with fluoroalkyl iodides2 • ;One-pot ipso-nitration of arylboronic acids3 • ;Copper-catalyzed nitration4 • ;Cyclocondensation followed by palladium-phosphine-catalyzed Suzuki-Miyaura coupling5 • ;Reagent used in Preparation of• ;Biaryls via nickel-catalyzed Suzuki-Miyaura cross-coupling reaction of aryl halides with arylboronic acid6† • ;Chromenones and their

Synthesis

5419-55-6

619-42-1

99768-12-4

In a 500 mL three-neck flask, methyl 4-bromobenzoate (20.2 g, 77.2 mmol) was dissolved in anhydrous THF (200.0 mL) and triisopropyl borate (18.9 g, 100.3 mmol) was added. The reaction mixture was cooled to -78 °C, N-butyllithium (6.8 g, 96.5 mmol) was slowly added dropwise and the reaction was kept at this temperature for 0.5 h. The reaction was completed with the addition of saturated chloride (1.2 mmol). Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution, followed by adjusting the pH with 1 mol/L hydrochloric acid to 1. The aqueous phase was extracted with ethyl acetate (100.0 mL x 3), the organic phases were combined, washed with saturated brine (60 mL x 1) and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, the residue was pulped with hexane, and 13.3 g of 4-methoxycarbonylphenylboronic acid was obtained after filtration in 95.5% yield.

References

[1] Patent: CN106565761, 2017, A. Location in patent: Paragraph 0063; 0064

4-(METHOXYCARBONYL)PHENYLBORONIC ACID Preparation Products And Raw materials

Raw materials

Trimethyl borate Nitrogen 4-Bromotoluene Tetrahydrofuran Potassium permanganate Methanol Magnesium

Preparation Products

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View Lastest Price from 4-(METHOXYCARBONYL)PHENYLBORONIC ACID manufacturers

Henan Fengda Chemical Co., Ltd

Product: 4-(METHOXYCARBONYL)PHENYLBORONIC ACID 99768-12-4
Price: US $34.00-1.20/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Changzhou waston chemical technology Co.,Ltd

Product: 4-(METHOXYCARBONYL)PHENYLBORONIC ACID 99768-12-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: according to customer's requirements
Release date: 2023-05-11

Hebei Maison Chemical Co.,Ltd.

Product: 4-Methoxycarbonylphenylboronic acid 99768-12-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: ≥99.0%
Supply Ability: 1000kg
Release date: 2023-03-28

99768-12-4, 4-(METHOXYCARBONYL)PHENYLBORONIC ACIDRelated Search:

Methyl benzenesulfonate Phenethylboronic acid Phenylboronic acid Basic Violet 1 4-Methoxyphenylboronic acid 4-Hydroxyphenylboronic acid 4-Tolylboronic acid Methyl acetate Acetonitrile Trimethyl borate Paraquat dichloride Methyl 2,2-dimethylphenylacetate Methyl acrylate Methyl benzoate Kresoxim-methyl Methyl anthranilate Methylparaben Isoquinoline-1-carboxylic acid

RARECHEM AH PB 0115

P-(METHOXYCARBONYL)PHENYLBORONIC ACID

METHYL 4-BORONOBENZOATE

AKOS BRN-0122

4-METHOXYCARBONYLBENZENEBORONIC ACID

4-METHOXYCARBONYLPHENYLBORONIC ACID

4-CARBOMETHOXYPHENYLBORONIC ACID

Methyl 4-boronobenzoate 4-(Methoxycarbonyl)phenylboronic acid

4-METHOXYCATBONYLPHENYLBORONICACID

4-(Methoxycabonyl)phenylboronic acid

4-METHOXYCARBONYLPHENYLBORONIC ACID 97%

4-(Methoxycarbonyl)phenylboronic Acid (contains varying amounts of Anhydride)

4-Methoxycarbonylphenylboronic acid,97%

4-borono-benzoic acid 1-methyl ester

4-Carbomethoxybenzeneboronic acid

Methyl p-boronobenzoate

p-(Methoxycarbonyl)boronic acid

p-borono-benzoic acid methyl ester

4-Methoxycarbonylphenylboronic

Methyl 4-boronobenzoate，4-(Methoxycarbonyl)benzeneboronic Acid

Methyl 4-boronobenzo

4-(Methoxycarbonyl)benzeneboronic acid 98%

4-methoxycarboxyphenylboronic acid

4-methoxybenzoborate

Benzoic acid, 4-borono-, 1-methyl ester

Blueberry extract anthocyanin

4-Methoxycarbonylphenylboronic(contains varying amounts of Anhydride)

(4-(Methoxycarbonyl)phenyl)boronic acid - [M4080]

99768-12-4

BORONIC ACID

Boronic Acids

Boronic Acids and Derivatives

Aryl

Organometallic Reagents

Aryl

Boronic acid

Organoborons

Acids and Derivatives

Boron, Nitrile, Thio,& TM-Cpds

blocks

BoronicAcids

Carboxes

Boronic Acid series

B (Classes of Boron Compounds)

CHIRAL CHEMICALS

Boronic acids

Aryl Boronic Acids

Boronic Acids and Derivatives

Chemical Synthesis

Monosubstituted Aryl Boronic Acids

Organometallic Reagents

Boronate Ester

Potassium Trifluoroborate