R(+)-BAY K 8644

Product Name: R(+)-BAY K 8644
CAS No.: 98791-67-4
Chemical Name: R(+)-BAY K 8644
Synonyms: R-4407;NI 105;BAY-r-4407;BAY-k 4407;(+)-BAY-K-8644;R(+)-BAY K 8644;Bay-K-8644 ((R)-(+)-);R(+)-BAY K 8644 98% 0 C;(+/-)-BAY K 8644, 0 TO 5 °C;(R)(+)BayK8644,(R) (+) Bay K 8644
CBNumber: CB9218808
Molecular Formula: C16H15F3N2O4
Formula Weight: 356.3
MOL File: 98791-67-4.mol

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R(+)-BAY K 8644 Property

storage temp.: 2-8°C
solubility: H₂O: slightly soluble
form: solid
color: yellow

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Safety

Hazard Codes: Xi
Risk Statements: 36/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15263
Product name: (+)-BAY-K-8644
Purity: ≥98%
Packaging: 1mg
Price: $110
Updated: 2024/03/01

Cayman Chemical

Product number: 15263
Product name: (+)-BAY-K-8644
Purity: ≥98%
Packaging: 5mg
Price: $218
Updated: 2024/03/01

Cayman Chemical

Product number: 15263
Product name: (+)-BAY-K-8644
Purity: ≥98%
Packaging: 10mg
Price: $273
Updated: 2024/03/01

Tocris

Product number: 1545
Product name: (R)-(+)-BayK8644
Purity: ≥97%(HPLC)
Packaging: 50
Price: $1184
Updated: 2021/12/16

TRC

Product number: B119010
Product name: (R)-(+)-BayK8644
Packaging: 2.5mg
Price: $225
Updated: 2021/12/16

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R(+)-BAY K 8644 Chemical Properties,Usage,Production

Description

BAY-K-8644, originally described as a modulator of potential operated calcium channels, exists as two enantiomers that have opposite actions. (R)-(+)-BAY-K-8644 is an L-type channel blocker that has negative inotropic and vasodilatory effects at 1 μM. Intracerebroventricular administration of this enantiomer has no effect on motor function in mice, whereas (S)-(−)-BAY-K-8644 impairs rotarod and motor activity, an effect that is blocked by (R)-(+)-BAY-K-8644.

Uses

(R)-(+)-Bay K 8644 is a Ca2+ channel inhibitor, whose enantiomer is a Ca2+ channel activator.

Definition

ChEBI: (R)-Bay-K-8644 is a methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate in which the 4-position has (R)-configuration. It is an enantiomer of a (S)-Bay-K-8644.

Biological Activity

L-type Ca 2+ -channel blocker with negative inotropic and vasodilatatory effects in vivo . Enantiomer showing opposite effects to the racemate (1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester ) and (S)-(-)- enantiomer ((4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester ). In combination with BIX-01294, helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs).

storage

Store at +4°C

References

[1] GERHARD FRANCKOWIAK. The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels[J]. European journal of pharmacology, 1985, 114 2: Pages 223-226. DOI: 10.1016/0014-2999(85)90631-4
[2] P ARTIGAS. Effects of the enantiomers of BayK 8644 on the charge movement of L-type Ca channels in guinea-pig ventricular myocytes.[J]. Journal of Membrane Biology, 2003, 193 3: 215-227. DOI: 10.1007/s00232-003-2020-1
[3] U RAVENS H P S. Opposite cardiac actions of the enantiomers of Bay K 8644 at different membrane potentials in guinea-pig papillary muscles.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 1990, 341 3: 232-239. DOI: 10.1007/bf00169736
[4] S.K. O’NEILL Gordon T B. Enantiomer selectivity and the development of tolerance to the behavioral effects of the calcium channel activator BAY K 8644[J]. Brain Research Bulletin, 1988, 21 6: Pages 865-872. DOI: 10.1016/0361-9230(88)90019-6

R(+)-BAY K 8644 Preparation Products And Raw materials

Raw materials

Preparation Products

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R(+)-BAY K 8644 Suppliers

China 60 Germany 2 Switzerland 1 United Kingdom 1 United States 12 Global 76

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98791-67-4, R(+)-BAY K 8644Related Search:

2-methyl-1-nitropropane 3-[o-(alpha,alpha,alpha-trifluorotolyl)]propionic acid Phenibut 4-AMINO-3-PHENYL-1-BUTANOL 3-(2-TRIFLUOROMETHYL-PHENYL)-PROPIONALDEHYDE METHYL 4-NITROBUTYRATE o-(trifluoromethyl)phenethylamine BETA-(NITROMETHYL)-BENZENEPROPANOIC ACID 1-NITRO-2-METHYL-BUTANE R(+)-BAY K 8644 3-(2-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL (+/-)-BAY K8644 CALCIUM SLOW CHANNEL,(RS)-BAY K 8644,BAY K-8644 (+/-),(+/-)-BAY K 8644 3-[(2-TRIFLUOROMETHYL)PHENYL]-1-PROPENE BAY K-8644 (+/-),(+/-)-BAY K 8644 S(-)-BAY K 8644 CA2+ CHANNEL ACTIVATO,S(-)-BAY K 8644 R(+)-BAY K 8644 CALCIUM CHANNEL (+-)-CAGED BAY K 8644 3-METHYL-4-NITRO-BUTYRALDEHYDE

(4R)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER

R-(+)-1,4-DIHYDRO-2,6-DIMETHY-5-NITRO-(2-[TRIFLUOROMETHYL]-PHENYL)-3-PYRIDINE CARBOXYLIC ACID METHYL ESTER

R(+)-BAY K 8644

R(+)-BAY K 8644 CA2(+) CHANNEL BLOCKE

(+/-)-BAY K 8644, 0 TO 5 °C

R(+)-BAY K 8644 98% 0 C

(4R)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethyl)phenyl)-3-pyridinecarboxylicacidmethylester

r-(+)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester

[4R,(+)]-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)pyridine-3-carboxylic acid methyl ester

BAY-r-4407

R-4407

BAY-k 4407

NI 105

Bay-K-8644 ((R)-(+)-)

BAY-K-8644 ((R)-(+)-);R-4407;NI-105;(+)-BAY-K-8644

(+)-methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)pyridine-5-carboxylate

3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-, methyl ester, (4R)-

(+)-BAY-K-8644

(R)(+)BayK8644,(R) (+) Bay K 8644

98791-67-4

Calcium channel