ChemicalBook > CAS DataBase List > R(+)-BAY K 8644

R(+)-BAY K 8644

Product Name
R(+)-BAY K 8644
CAS No.
98791-67-4
Chemical Name
R(+)-BAY K 8644
Synonyms
R-4407;NI 105;BAY-r-4407;BAY-k 4407;(+)-BAY-K-8644;R(+)-BAY K 8644;Bay-K-8644 ((R)-(+)-);R(+)-BAY K 8644 98% 0 C;(+/-)-BAY K 8644, 0 TO 5 °C;(R)(+)BayK8644,(R) (+) Bay K 8644
CBNumber
CB9218808
Molecular Formula
C16H15F3N2O4
Formula Weight
356.3
MOL File
98791-67-4.mol
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R(+)-BAY K 8644 Property

storage temp. 
2-8°C
solubility 
H2O: slightly soluble
form 
solid
color 
yellow
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Safety

Hazard Codes 
Xi
Risk Statements 
36/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15263
Product name
(+)-BAY-K-8644
Purity
≥98%
Packaging
1mg
Price
$110
Updated
2024/03/01
Cayman Chemical
Product number
15263
Product name
(+)-BAY-K-8644
Purity
≥98%
Packaging
5mg
Price
$218
Updated
2024/03/01
Cayman Chemical
Product number
15263
Product name
(+)-BAY-K-8644
Purity
≥98%
Packaging
10mg
Price
$273
Updated
2024/03/01
Tocris
Product number
1545
Product name
(R)-(+)-BayK8644
Purity
≥97%(HPLC)
Packaging
50
Price
$1184
Updated
2021/12/16
TRC
Product number
B119010
Product name
(R)-(+)-BayK8644
Packaging
2.5mg
Price
$225
Updated
2021/12/16
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R(+)-BAY K 8644 Chemical Properties,Usage,Production

Description

BAY-K-8644, originally described as a modulator of potential operated calcium channels, exists as two enantiomers that have opposite actions. (R)-(+)-BAY-K-8644 is an L-type channel blocker that has negative inotropic and vasodilatory effects at 1 μM. Intracerebroventricular administration of this enantiomer has no effect on motor function in mice, whereas (S)-(−)-BAY-K-8644 impairs rotarod and motor activity, an effect that is blocked by (R)-(+)-BAY-K-8644.

Uses

(R)-(+)-Bay K 8644 is a Ca2+ channel inhibitor, whose enantiomer is a Ca2+ channel activator.

Definition

ChEBI: (R)-Bay-K-8644 is a methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate in which the 4-position has (R)-configuration. It is an enantiomer of a (S)-Bay-K-8644.

Biological Activity

L-type Ca 2+ -channel blocker with negative inotropic and vasodilatatory effects in vivo . Enantiomer showing opposite effects to the racemate (1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester ) and (S)-(-)- enantiomer ((4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester ). In combination with BIX-01294, helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs).

storage

Store at +4°C

R(+)-BAY K 8644 Preparation Products And Raw materials

Raw materials

Preparation Products

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R(+)-BAY K 8644 Suppliers

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98791-67-4, R(+)-BAY K 8644Related Search:

2-methyl-1-nitropropane 3-[o-(alpha,alpha,alpha-trifluorotolyl)]propionic acid Phenibut 4-AMINO-3-PHENYL-1-BUTANOL 3-(2-TRIFLUOROMETHYL-PHENYL)-PROPIONALDEHYDE METHYL 4-NITROBUTYRATE o-(trifluoromethyl)phenethylamine BETA-(NITROMETHYL)-BENZENEPROPANOIC ACID 1-NITRO-2-METHYL-BUTANE R(+)-BAY K 8644 3-(2-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL (+/-)-BAY K8644 CALCIUM SLOW CHANNEL,(RS)-BAY K 8644,BAY K-8644 (+/-),(+/-)-BAY K 8644 3-[(2-TRIFLUOROMETHYL)PHENYL]-1-PROPENE BAY K-8644 (+/-),(+/-)-BAY K 8644 S(-)-BAY K 8644 CA2+ CHANNEL ACTIVATO,S(-)-BAY K 8644 R(+)-BAY K 8644 CALCIUM CHANNEL (+-)-CAGED BAY K 8644 3-METHYL-4-NITRO-BUTYRALDEHYDE

  • (4R)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER
  • R-(+)-1,4-DIHYDRO-2,6-DIMETHY-5-NITRO-(2-[TRIFLUOROMETHYL]-PHENYL)-3-PYRIDINE CARBOXYLIC ACID METHYL ESTER
  • R(+)-BAY K 8644
  • R(+)-BAY K 8644 CA2(+) CHANNEL BLOCKE
  • (+/-)-BAY K 8644, 0 TO 5 °C
  • R(+)-BAY K 8644 98% 0 C
  • (4R)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethyl)phenyl)-3-pyridinecarboxylicacidmethylester
  • r-(+)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
  • [4R,(+)]-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)pyridine-3-carboxylic acid methyl ester
  • BAY-r-4407
  • R-4407
  • BAY-k 4407
  • NI 105
  • Bay-K-8644 ((R)-(+)-)
  • BAY-K-8644 ((R)-(+)-);R-4407;NI-105;(+)-BAY-K-8644
  • (+)-methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)pyridine-5-carboxylate
  • 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-, methyl ester, (4R)-
  • (+)-BAY-K-8644
  • (R)(+)BayK8644,(R) (+) Bay K 8644
  • 98791-67-4
  • Calcium channel