Lup-20(29)-ene-1β,3α-diol
- Product Name
- Lup-20(29)-ene-1β,3α-diol
- CAS No.
- 6610-56-6
- Chemical Name
- Lup-20(29)-ene-1β,3α-diol
- Synonyms
- Glochidiol;Lup-20(29)-ene-1β,3α-diol;Lup-20(29)-ene-1,3-diol,(1a,3R)-;Lup-20(29)-ene-1,3-diol, (1β,3α)-
- CBNumber
- CB92247143
- Molecular Formula
- C30H50O2
- Formula Weight
- 442.72
- MOL File
- 6610-56-6.mol
Lup-20(29)-ene-1β,3α-diol Property
- Melting point:
- 260-262 °C(Solv: chloroform (67-66-3); methanol (67-56-1))
- Boiling point:
- 518.1±50.0 °C(Predicted)
- Density
- 1.021±0.06 g/cm3(Predicted)
- pka
- 14.77±0.70(Predicted)
N-Bromosuccinimide Price
- Product number
- CFN97128
- Product name
- Glochidiol
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $463
- Updated
- 2021/12/16
- Product number
- CD32000683
- Product name
- Glochidiol
- Purity
- 95+%
- Packaging
- 5mg
- Price
- $730
- Updated
- 2021/12/16
Lup-20(29)-ene-1β,3α-diol Chemical Properties,Usage,Production
Uses
Glochidiol is an orally active tubulin polymerization inhibitor with an IC50 of 2.76 μM. Glochidiol shows anti-cancer activity[1].
Definition
ChEBI: 20(29)-lupene-1beta,3alpha-diol is a pentacyclic triterpenoid that is lup-20(29)-ene substituted by hydroxy groups at positions 1 and 3 respectively (the 1beta,3alpha-stereoisomer). It has been isolated from Breynia fruticosa. It has a role as a plant metabolite. It is a pentacyclic triterpenoid and a diol. It derives from a hydride of a lupane.
in vivo
Glochidiol (60 mg/kg/day; i.g.; 21 days) effectively inhibits lung cancer HCC-44 xenograft tumor growth in nude mice[1].
| Animal Model: | BALB/c nude mice bearing HCC-44 xenografts[1] |
| Dosage: | 60 mg/kg/day |
| Administration: | Intragastric administration for a period of 21 days |
| Result: | Decreased average tumor weight and relative tumor volume with no obvious cytotoxic effect on the major organs, including heart, liver, and kidney. |
References
[1] Chen H, et al. Glochidiol, a natural triterpenoid, exerts its anti-cancer effects by targeting the colchicine binding site of tubulin. Invest New Drugs. 2021 Apr;39(2):578-586. DOI:10.1007/s10637-020-01013-1
Lup-20(29)-ene-1β,3α-diol Preparation Products And Raw materials
Raw materials
Preparation Products
Lup-20(29)-ene-1β,3α-diol Suppliers
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6005
- Advantage
- 61
- Tel
- 0871-65217109 13211707573;
- Fax
- 0871-65215563
- y.liu@mail.biobiopha.com
- Country
- China
- ProdList
- 5653
- Advantage
- 65
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7787
- Advantage
- 56
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15178
- Advantage
- 58
- Tel
- 86-021-61559134 15921386130
- Fax
- 021-55068248
- 3423497944@qq.com
- Country
- China
- ProdList
- 8144
- Advantage
- 55
- Tel
- 18607101326 15172504745
- Fax
- +86-27-84254680
- aileen@chemfaces.com
- Country
- China
- ProdList
- 6905
- Advantage
- 55
- Tel
- 888-539-0666
- Fax
- 888-539-0666
- info@emmx.com
- Country
- United States
- ProdList
- 8447
- Advantage
- 60
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71829
- Advantage
- 60
- Tel
- 021-61847300 13341622919
- Fax
- 021-61847300
- shcss01@163.com
- Country
- China
- ProdList
- 4808
- Advantage
- 58
- Tel
- 028-85370565-229 18080489829
- 3004654993@qq.com
- Country
- China
- ProdList
- 8914
- Advantage
- 60