Trihexylphenedyl
- Product Name
- Trihexylphenedyl
- CAS No.
- 144-11-6
- Chemical Name
- Trihexylphenedyl
- Synonyms
- TRIHEXYPHENIDYL;Benzhexol;Artane;Trihexylphenidyl;1-cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol;Triphenidyl;rihexylphenedyl;Trihexylphenedyl;Parkinane retard;Trihexylphenizyl
- CBNumber
- CB9234619
- Molecular Formula
- C20H31NO
- Formula Weight
- 301.47
- MOL File
- 144-11-6.mol
Trihexylphenedyl Property
- Melting point:
- 258.5°C
- Boiling point:
- 442.59°C (rough estimate)
- Density
- 0.9941 (rough estimate)
- refractive index
- 1.5614 (estimate)
- pka
- 14.31±0.29(Predicted)
- NIST Chemistry Reference
- Trihexyphenidyl(144-11-6)
Safety
- Hazardous Substances Data
- 144-11-6(Hazardous Substances Data)
- Toxicity
- LD50 ipr-mus: 150 mg/kg ARZNAD 21,1727,71
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- API0005652
- Product name
- TRIHEXYPHENIDYL
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $494.55
- Updated
- 2021/12/16
Trihexylphenedyl Chemical Properties,Usage,Production
Originator
Artane,Lederle,US,1949
Uses
Trihexyphenidyl, an antiparkinsonian drug, possesses central and peripheral anticholinergic actions, as well as a direct relaxant effect on smooth muscle. It reduces muscle rigidity and general stiffness, and has a relatively minor effect on tremors. It is used in Parkinsonism in the form of monotherapy as well as in combination with levodopa.
Uses
Anticholinergic; antiparkinsonian.
Definition
ChEBI: Trihexyphenidyl is an amine.
Manufacturing Process
Acetophenone, paraformaldehyde and piperidine are first reacted to give ω-(1-
piperidyl)propiophenone.
To an absolute ethyl ether solution of cyclohexylmagnesium bromide
(prepared from 261 parts of cyclohexyl bromide, 38.8 parts magnesium
turnings and 700 parts by volume absolute ethyl ether) a dry solution of 174
parts omega-(1-piperidyl)-propiophenonein 600 parts by volume of ether is
added, with stirring, at such a rate that gentle reflux is maintained with no
external cooling or heating. The reaction mixture is stirred for about 5 hours
and then allowed to stand at room temperature until reaction appears
complete. While being cooled the reaction mixture is then decomposed by the
dropwise addition of 500 parts by volume of 2.5 N hydrochloric acid, and
finally is made strongly acidic to Congo red by the addition of concentrated
hydrochloric acid.
The resulting white solid is collected on a filter, air dried, redissolved in 2,500
parts water at 95°C and the resulting solution treated with decolorizing
charcoal and clarified by filtration. The cooled filtrate is made alkaline with
ammonia and the product, crude 3-(1-piperidyl)-1-cyclohexyl-1-phenyl-1-
propanol is collected. The hydrochloride melts with decomposition in ten
seconds in a bath held at 258.5°C. The alcohol melts at 114.3° to 115.0°C,
according to US Patent 2,716,121.
brand name
Artane (Lederle); Tremin (Schering).
Therapeutic Function
Antiparkinsonian
Safety Profile
Poison by intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.
Synthesis
Trihexyphenidyl, 1-cyclohexyl-1-phenyl-3-piperidineopropan-1-ol (10.2.2), is synthesized by the reaction of 2-(1-piperidino)propiophenone (10.2.1) with cyclohexylmagnesiumbromide. The initial 2-(1-piperidino)propiophenone is synthesized in turn by the aminomethylation of benzophenone using paraformaldehyde and piperidine [24¨C27].
Trihexylphenedyl Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Trihexylphenedyl manufacturers
- Product
- Trihexylphenedyl 144-11-6
- Price
- US $49.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000 tons
- Release date
- 2023-03-30
- Product
- Trihexylphenedyl 144-11-6
- Price
- US $180.00/kgkg
- Min. Order
- 1kgkg
- Purity
- 0.99
- Supply Ability
- 100
- Release date
- 2023-09-07
- Product
- Trihexylphenedyl 144-11-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2022-09-29