4-FLUORO-3-METHOXYPHENYLBORONIC ACID
- Product Name
- 4-FLUORO-3-METHOXYPHENYLBORONIC ACID
- CAS No.
- 854778-31-7
- Chemical Name
- 4-FLUORO-3-METHOXYPHENYLBORONIC ACID
- Synonyms
- uoro-3-methoxyphenyL;Elagolix Impurity 50;5-Borono-2-fluoroanisole;4-Fluoro-3-Methoxyphenylboronic;4-Fluoro-5-methoxyphenylboronic acid;4-FLUORO-3-METHOXYPHENYLBORONIC ACID;4-FLUORO-3-METHOXYBENZENEBORONIC ACID;4-Fluoro-3-methoxybenzeneboronicacid98%;4-Fluoro-3-methoxybenzeneboronic acid 98%;Boronic acid, B-(4-fluoro-3-methoxyphenyl)-
- CBNumber
- CB9237771
- Molecular Formula
- C7H8BFO3
- Formula Weight
- 169.95
- MOL File
- 854778-31-7.mol
4-FLUORO-3-METHOXYPHENYLBORONIC ACID Property
- Melting point:
- 189-191
- Boiling point:
- 318.1±52.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 8.19±0.10(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C7H8BFO3/c1-12-7-4-5(8(10)11)2-3-6(7)9/h2-4,10-11H,1H3
- InChIKey
- LUJMSRVFSBMEOY-UHFFFAOYSA-N
- SMILES
- B(C1=CC=C(F)C(OC)=C1)(O)O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F0919
- Product name
- 4-Fluoro-3-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $51
- Updated
- 2025/07/31
- Product number
- F0919
- Product name
- 4-Fluoro-3-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $167
- Updated
- 2025/07/31
- Product number
- F595678
- Product name
- 4-Fluoro-3-methoxyphenylboronicacid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- F595678
- Product name
- 4-Fluoro-3-methoxyphenylboronicacid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-W003444
- Product name
- 4-Fluoro-3-methoxybenzeneboronic acid
- Purity
- 98.11%
- Packaging
- 10g
- Price
- $87
- Updated
- 2021/12/16
4-FLUORO-3-METHOXYPHENYLBORONIC ACID Chemical Properties,Usage,Production
Uses
suzuki reaction
Synthesis
103291-07-2
854778-31-7
General procedure for the synthesis of 4-fluoro-3-methoxyphenylboronic acid from 2-fluoro-5-bromoanisole: To a solution of 2-fluoro-5-bromoanisole (2.7 g, 13.1 mmol) in tetrahydrofuran (THF, 25 mL) was slowly added n-butyllithium (n-BuLi, 1.6 M solution in hexane, 11.0 mL, 17.7 mmol) at -78 °C. The reaction mixture was stirred continuously at -78 °C for 40 min, followed by the addition of trimethyl borate (2.7 mL, 24.3 mmol). The reaction system was slowly warmed from -78 °C to room temperature and stirring was continued at this temperature for 18 hours. Upon completion of the reaction, the reaction was quenched with 1.0 N hydrochloric acid (40 mL) and subsequently extracted with ethyl acetate (EtOAc). The organic phase was washed with saturated brine and dried over anhydrous sodium sulfate (Na2SO4). After removal of solvent by evaporation under reduced pressure, the crude product obtained was purified by grinding with a solvent mixture of ethyl acetate/hexane (1:4, v/v). After filtration, the target product 4-fluoro-3-methoxyphenylboronic acid (0.75 g, 35% yield) was obtained as a white solid. The structure of the product was confirmed by 1H NMR (400 MHz, methanol-d4) with chemical shifts of δ 3.86 (s, 3H) and 7.03-7.45 (m, 3H).
References
[1] Patent: US2010/227894, 2010, A1. Location in patent: Page/Page column 28
[2] Patent: US2007/3539, 2007, A1. Location in patent: Page/Page column 71
4-FLUORO-3-METHOXYPHENYLBORONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-FLUORO-3-METHOXYPHENYLBORONIC ACID manufacturers
- Product
- 4-FLUORO-3-METHOXYPHENYLBORONIC ACID 854778-31-7
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-07-04
- Product
- 4-FLUORO-3-METHOXYPHENYLBORONIC ACID 854778-31-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 4-FLUORO-3-METHOXYPHENYLBORONIC ACID 854778-31-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09