(+)-Polyneuridine
- Product Name
- (+)-Polyneuridine
- CAS No.
- 639-36-1
- Chemical Name
- (+)-Polyneuridine
- Synonyms
- Rhazin;Rhazine;Akuammidine;(+)-Polyneuridine;SARPAGAN-16-CARBOXYLIC ACID17-HYDROXY-,METHYL ESTER;17-Hydroxysarpagane-16-carboxylic acid methyl ester
- CBNumber
- CB92397389
- Molecular Formula
- C21H24N2O3
- Formula Weight
- 352.43
- MOL File
- 639-36-1.mol
(+)-Polyneuridine Property
- Melting point:
- 243-246℃
- Boiling point:
- 513.0±50.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- pka
- 14.79±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- CD32000741
- Product name
- Akuammidine
- Purity
- 95+%
- Packaging
- 5mg
- Price
- $922
- Updated
- 2021/12/16
(+)-Polyneuridine Chemical Properties,Usage,Production
Uses
Akuammidine, isolated from the seeds of Picralima nitida, shows a preference for μ-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 μM at μ-, σ- and κ-opioid binding sites, respectively. Akuammidine possesses anti-inflammatory and anti-asthmatic properties[1][2].
IC 50
κ Opioid Receptor/KOR
References
[1] Yuanyuan Hou, et al. Microfractionation Bioactivity-Based Ultra Performance Liquid Chromatography/Quadrupole Time-Of-Flight Mass Spectrometry for the Identification of Nuclear factor-κB Inhibitors and β2 Adrenergic Receptor Agonists in an Alkaloidal Extract of the Folk Herb Alstonia Scholaris. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Nov 1;908:98-104. DOI:10.1016/j.jchromb.2012.10.004
[2] J R Menzies, et al. Opioid Activity of Alkaloids Extracted From Picralima Nitida (Fam. Apocynaceae). Eur J Pharmacol. 1998 May 29;350(1):101-8. DOI:10.1016/s0014-2999(98)00232-5
(+)-Polyneuridine Preparation Products And Raw materials
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