ChemicalBook > CAS DataBase List > 1-CHLORO-7-METHYLISOQUINOLINE

1-CHLORO-7-METHYLISOQUINOLINE

Product Name
1-CHLORO-7-METHYLISOQUINOLINE
CAS No.
24188-80-5
Chemical Name
1-CHLORO-7-METHYLISOQUINOLINE
Synonyms
1-Chlor-7-methyl-isochinolin;1-CHLORO-7-METHYLISOQUINOLINE;Isoquinoline, 1-chloro-7-methyl-
CBNumber
CB92452462
Molecular Formula
C10H8ClN
Formula Weight
177.63
MOL File
24188-80-5.mol
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1-CHLORO-7-METHYLISOQUINOLINE Property

Boiling point:
284.8±20.0 °C(Predicted)
Density 
1.225±0.06 g/cm3(Predicted)
pka
2.31±0.33(Predicted)
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Safety

HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C374458
Product name
1-chloro-7-methylisoquinoline
Packaging
100mg
Price
$155
Updated
2021/12/16
Apolloscientific
Product number
OR964809
Product name
1-Chloro-7-methylisoquinoline
Purity
95%
Packaging
100mg
Price
$182
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-5-LW
Product name
1-Chloro-7-methylisoquinoline
Purity
95%
Packaging
100mg
Price
$200
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC159688
Product name
1-Chloro-7-methylisoquinoline
Packaging
250mg
Price
$275
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-5-LW
Product name
1-Chloro-7-methylisoquinoline
Purity
95%
Packaging
250mg
Price
$360
Updated
2021/12/16
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1-CHLORO-7-METHYLISOQUINOLINE Chemical Properties,Usage,Production

Synthesis

26829-47-0

24188-80-5

General procedure for the synthesis of 1-chloro-7-methylisoquinoline from 1-hydroxy-7-methylisoquinoline: phosphorus oxychloride (POCl3, 10 mL) was mixed with 7-methylisoquinolin-1-ol (3.55 g, 22.3 mmol) under the protection of nitrogen and the reaction was carried out by heating and refluxing for 5 hours. Upon completion of the reaction, excess POCl3 was removed by distillation.The residue was quenched with ice water and subsequently extracted with dichloromethane (3×). The organic phases were combined and purified by fast silica gel column chromatography using a hexane solution of 10-25% ethyl acetate as eluent to afford the target product 1-chloro-7-methylisoquinoline (3.40 g, 85% yield). The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 8.21 (d, 1H), 8.11 (s, 1H), 7.75 (d, 1H), 7.60 (d, 1H), 7.55 (d, 1H), 2.60 (s, 3H).

References

[1] Patent: US2007/225282, 2007, A1. Location in patent: Page/Page column 29

1-CHLORO-7-METHYLISOQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-CHLORO-7-METHYLISOQUINOLINE Suppliers

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  • 1-CHLORO-7-METHYLISOQUINOLINE
  • 1-Chlor-7-methyl-isochinolin
  • Isoquinoline, 1-chloro-7-methyl-
  • 24188-80-5