1-CHLORO-7-METHYLISOQUINOLINE
- Product Name
- 1-CHLORO-7-METHYLISOQUINOLINE
- CAS No.
- 24188-80-5
- Chemical Name
- 1-CHLORO-7-METHYLISOQUINOLINE
- Synonyms
- 1-Chlor-7-methyl-isochinolin;1-CHLORO-7-METHYLISOQUINOLINE;Isoquinoline, 1-chloro-7-methyl-
- CBNumber
- CB92452462
- Molecular Formula
- C10H8ClN
- Formula Weight
- 177.63
- MOL File
- 24188-80-5.mol
1-CHLORO-7-METHYLISOQUINOLINE Property
- Boiling point:
- 284.8±20.0 °C(Predicted)
- Density
- 1.225±0.06 g/cm3(Predicted)
- pka
- 2.31±0.33(Predicted)
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C374458
- Product name
- 1-chloro-7-methylisoquinoline
- Packaging
- 100mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- OR964809
- Product name
- 1-Chloro-7-methylisoquinoline
- Purity
- 95%
- Packaging
- 100mg
- Price
- $182
- Updated
- 2021/12/16
- Product number
- 3H32-5-LW
- Product name
- 1-Chloro-7-methylisoquinoline
- Purity
- 95%
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FC159688
- Product name
- 1-Chloro-7-methylisoquinoline
- Packaging
- 250mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- HCH0320728
- Product name
- 1-CHLORO-7-METHYLISOQUINOLINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $289.8
- Updated
- 2021/12/16
1-CHLORO-7-METHYLISOQUINOLINE Chemical Properties,Usage,Production
Synthesis
26829-47-0
24188-80-5
General procedure for the synthesis of 1-chloro-7-methylisoquinoline from 1-hydroxy-7-methylisoquinoline: phosphorus oxychloride (POCl3, 10 mL) was mixed with 7-methylisoquinolin-1-ol (3.55 g, 22.3 mmol) under the protection of nitrogen and the reaction was carried out by heating and refluxing for 5 hours. Upon completion of the reaction, excess POCl3 was removed by distillation.The residue was quenched with ice water and subsequently extracted with dichloromethane (3×). The organic phases were combined and purified by fast silica gel column chromatography using a hexane solution of 10-25% ethyl acetate as eluent to afford the target product 1-chloro-7-methylisoquinoline (3.40 g, 85% yield). The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 8.21 (d, 1H), 8.11 (s, 1H), 7.75 (d, 1H), 7.60 (d, 1H), 7.55 (d, 1H), 2.60 (s, 3H).
References
[1] Patent: US2007/225282, 2007, A1. Location in patent: Page/Page column 29
1-CHLORO-7-METHYLISOQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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