ChemicalBook > CAS DataBase List > JNJ 1661010

JNJ 1661010

Solubility

Product Name: JNJ 1661010
CAS No.: 681136-29-8
Chemical Name: JNJ 1661010
Synonyms: 1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-;CS-1527;Takeda-25;JNJ 1661010;JNJ 1661010, >=98%;JNJ-1661010 ，S2828;JNJ 1661010 USP/EP/BP;JNJ-1661010, 10 mM in DMSO;TAKEDA-25;JNJ-1661010;JNJ 1661010;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide
CBNumber: CB92457306
Molecular Formula: C19H19N5OS
Formula Weight: 365.45
MOL File: 681136-29-8.mol

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JNJ 1661010 Property

Density: 1.340±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: ≥28mg/mL
form: solid
pka: 13.94±0.70(Predicted)
color: Off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

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Safety

WGK Germany: 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 14497
Product name: JNJ-1661010
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 14497
Product name: JNJ-1661010
Purity: ≥98%
Packaging: 10mg
Price: $110
Updated: 2024/03/01

Cayman Chemical

Product number: 14497
Product name: JNJ-1661010
Purity: ≥98%
Packaging: 25mg
Price: $198
Updated: 2024/03/01

Cayman Chemical

Product number: 14497
Product name: JNJ-1661010
Purity: ≥98%
Packaging: 50mg
Price: $359
Updated: 2024/03/01

Tocris

Product number: 3262
Product name: JNJ1661010
Purity: ≥99%(HPLC)
Packaging: 50
Price: $626
Updated: 2021/12/16

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JNJ 1661010 Chemical Properties,Usage,Production

Solubility

JNJ 1661010 is soluble to 100 mM in DMSO and to 10 mM in ethanol.

Description

JNJ-1661010 (681136-29-8) is a potent and selective FAAH inhibitor. Initially forms a covalent adduct with FAAH but is slowly released, IC50 = 12 nM. 100-fold selectivity for FAAH-1 over FAAH-2. Cell permeable and active in vivo. JNJ-1661010 displays analgesic activity in various animal models.

Uses

JNJ-1661010, is used to examine the contribution of endocannabinoid signaling in experimental fibrosis. In biological studies, this compound had shown to elevate the levels of arachidonoyl ethanolamide (AEA) in rat brains.

Definition

ChEBI: JNJ-1661010 is a N-arylpiperazine.

Biological Activity

Selective, reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC 50 = 12nM). Brain penetrant and active in vivo .

Synthesis

306935-14-8

103-71-9

681136-29-8

GENERAL STEPS: A solution of 1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine (1.00 g, 4.06 mmol) and triethylamine (0.565 mL, 4.06 mmol) in tetrahydrofuran (20 mL) was added to a 25 mL round bottom flask. The reaction mixture was cooled to 0°C in an ice bath, followed by slow dropwise addition of phenyl isocyanate (0.529 mL, 4.87 mmol). After the dropwise addition was completed, the ice bath was removed and the reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, diisopropyl ether (40 mL) was added to the mixture to precipitate the product. The solid was collected by filtration and recrystallized with a mixed solvent of hexane and ethyl acetate (1:1, v/v) to afford N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide 1.19 g in 80.4% yield as a white solid. The structure of the product was confirmed by 1H-NMR (CDCl3): δ 3.70 (8H, s), 6.43 (1H, s), 7.06-7.11 (1H, m), 7.29-7.46 (7H, m), 8.17-8.21 (2H, m).

storage

Store at +4°C

References

[1] MARK J KARBARZ. Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase.[J]. Anesthesia and analgesia, 2009, 108 1: 316-329. DOI:10.1213/ane.0b013e31818c7cbd

JNJ 1661010 Preparation Products And Raw materials

Raw materials

Preparation Products

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JNJ 1661010 Suppliers

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681136-29-8, JNJ 1661010Related Search:

Fatostatin A URB597 Palmitoylethanolamide 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE I-BET151 (GSK1210151A) Selumetinib Quizartinib (AC220) GSK256066 SGX-523 BI-D1870 5-AMINO-3-METHYL-1,2,4-THIADIAZOLE 3-PHENYL-5-PIPERAZINO-1,2,4-THIADIAZOLE JNJ 1661010 5-Amino-1,2,4-thiadiazole 5-AMINO-3-PHENYL-1,2,4-THIADIAZOLE

JNJ 1661010

N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide

Takeda-25

1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-

JNJ 1661010, >=98%

CS-1527

N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

TAKEDA-25;JNJ-1661010;JNJ 1661010

JNJ 1661010 USP/EP/BP

broad-spectrum,acid,inhibit,hydrolase,barrier,JNJ-1661010,FAAH,Takeda25,Fatty acid amide hydrolase,amide,Takeda 25,blood-brain,Inhibitor,analgesics,Fatty

JNJ-1661010, 10 mM in DMSO

JNJ-1661010 ，S2828

681136-29-8

Inhibitors

Inhibitor