JNJ 1661010
Solubility- Product Name
- JNJ 1661010
- CAS No.
- 681136-29-8
- Chemical Name
- JNJ 1661010
- Synonyms
- 1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-;CS-1527;Takeda-25;JNJ 1661010;JNJ 1661010, >=98%;JNJ 1661010 USP/EP/BP;TAKEDA-25;JNJ-1661010;JNJ 1661010;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide;broad-spectrum,acid,inhibit,hydrolase,barrier,JNJ-1661010,FAAH,Takeda25,Fatty acid amide hydrolase,amide,Takeda 25,blood-brain,Inhibitor,analgesics,Fatty
- CBNumber
- CB92457306
- Molecular Formula
- C19H19N5OS
- Formula Weight
- 365.45
- MOL File
- 681136-29-8.mol
JNJ 1661010 Property
- Density
- 1.340±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: ≥28mg/mL
- form
- solid
- pka
- 13.94±0.70(Predicted)
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Safety
- WGK Germany
- 1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P370+P378In case of fire: Use … for extinction.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 14497
- Product name
- JNJ-1661010
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 14497
- Product name
- JNJ-1661010
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $110
- Updated
- 2024/03/01
- Product number
- 14497
- Product name
- JNJ-1661010
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $198
- Updated
- 2024/03/01
- Product number
- 14497
- Product name
- JNJ-1661010
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $359
- Updated
- 2024/03/01
- Product number
- 3262
- Product name
- JNJ1661010
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $626
- Updated
- 2021/12/16
JNJ 1661010 Chemical Properties,Usage,Production
Solubility
JNJ 1661010 is soluble to 100 mM in DMSO and to 10 mM in ethanol.
Description
JNJ-1661010 (681136-29-8) is a potent and selective FAAH inhibitor. Initially forms a covalent adduct with FAAH but is slowly released, IC50 = 12 nM. 100-fold selectivity for FAAH-1 over FAAH-2. Cell permeable and active in vivo. JNJ-1661010 displays analgesic activity in various animal models.
Uses
JNJ-1661010, is used to examine the contribution of endocannabinoid signaling in experimental fibrosis. In biological studies, this compound had shown to elevate the levels of arachidonoyl ethanolamide (AEA) in rat brains.
Definition
ChEBI: JNJ-1661010 is a N-arylpiperazine.
Biological Activity
Selective, reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC 50 = 12nM). Brain penetrant and active in vivo .
storage
Store at +4°C
References
1) Karbarz et al. (2009), Biochemical and biological properties of 4-(3-phenyl-[1,2,4]thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase; Anesth. Analg., 108 316
JNJ 1661010 Preparation Products And Raw materials
Raw materials
Preparation Products
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