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Bafetinib

Product Name
Bafetinib
CAS No.
859212-16-1
Chemical Name
Bafetinib
Synonyms
Benil;Ns 187;CS-239;Rhinon;Inno-406;Inno 406;Rinazina;Unii-nvw4Z03I9b;NS-187|||INNO-406;Bafetinib (INNO-406)
CBNumber
CB92473854
Molecular Formula
C30H31F3N8O
Formula Weight
576.62
MOL File
859212-16-1.mol
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Bafetinib Property

Melting point:
166-168°C
Density 
1.36±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
DMSO:42.0(Max Conc. mg/mL);72.84(Max Conc. mM)
form 
A crystalline solid
pka
12.72±0.70(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19169
Product name
Bafetinib
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
19169
Product name
Bafetinib
Purity
≥98%
Packaging
5mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
19169
Product name
Bafetinib
Purity
≥98%
Packaging
10mg
Price
$214
Updated
2024/03/01
TRC
Product number
B109050
Product name
Bafetinib
Packaging
5mg
Price
$90
Updated
2021/12/16
Biorbyt Ltd
Product number
orb180774
Product name
Bafetinib (INNO-406)
Purity
>98%
Packaging
1g
Price
$2172.6
Updated
2021/12/16
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Bafetinib Chemical Properties,Usage,Production

Description

Bcr-Abl, a fusion protein with deregulated tyrosine kinase activity, is highly expressed in chronic myelogenous leukemia (CML). Bafetinib is a rationally developed tyrosine kinase inhibitor based on the chemical structure of imatinib , with modifications added to improve binding and potency against Bcr-Abl kinase (IC50 = 5.8 nM). It is 25- to 55-fold more potent than imatinib in vitro and ≥10-fold more potent in vivo. Bafetinib inhibits 12 out of the 13 most frequent imatinib-resistant Bcr-Abl point mutations, but not the T315I mutation and also targets the Src family kinase Lyn (IC50 = 19 nM), which has been associated with resistance to imatinib in CML.

Chemical Properties

Pale Yellow Solid

Uses

A substituted benzamide derivative structurally related to STI-571 (Imatinib Mesylate). It was identified as highly potent Bcr-Abl kinase inhibitor.

Bafetinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Bafetinib Suppliers

Canada 1 China 88 India 2 United Kingdom 2 United States 16 Global 109
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from Bafetinib manufacturers

Dideu Industries Group Limited
Product
Bafetinib 859212-16-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-06
Career Henan Chemical Co
Product
Bafetinib 859212-16-1
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-22

859212-16-1, BafetinibRelated Search:

Erlotinib Sunitinib Flumatinib mesylate Baricitinib Bortezomib Bosutinib Nilotinib Vismodegib (GDC-0449) Trametinib Ibrutinib

  • Benzamide, N-(3-((4,5'-bipyrimidin)-2-ylamino)-4-methylphenyl)-4-(((3S)-3-(dimethylamino)-1-pyrrolidinyl)methyl)-3-(trifluoromethyl)-
  • Inno 406
  • Inno-406
  • 4-[[(3S)-3-Dimethylaminopyrrolidin-1-yl]methyl]-N-[4-methyl-3-[(4-pyrimidin-5-ylpyrimidin-2-yl)amino]phenyl]-3-(trifluoromethyl)benzamide
  • NS-187; BAFETINIB; INNO406
  • CS-239
  • INNO 406 - Bafetinib
  • Ns 187
  • Unii-nvw4Z03I9b
  • Bafetinib (INNO-406)
  • N-[3-([4,5'-BipyriMidin]-2-ylaMino)-4-Methylphenyl]-4-[[(3S)-3-(diMethylaMino)-1-pyrrolidinyl]Methyl]-3-(trifluoroMethyl)benzaMide
  • Bafetinib(INNO 406,NS 187)
  • (S)-N-(3-([4,5'-bipyriMidin]-2-ylaMino)-4-Methylphenyl)-4-((3-(diMethylaMino)pyrrolidin-1-yl)Methyl)-3-(trifluoroMethyl)benzaMide
  • (S)-4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-N-(4-methyl-3-(4-(pyrimidin-5-yl)pyrimidin-2-ylamino)phenyl)-3-(trifluoromethyl)benzamide
  • Bafetinib N-[3-([4,5'-bipyrimidin]-2-ylamino)-4-methylphenyl]-4-[[(3S)-3-(dimethylamino)-1-pyrrolidinyl]methyl]-3-(trifluoromethyl)benzamide
  • Benil
  • Rhinon
  • Rinazina
  • (S)-N-(3-([4,5'-Bipyrimidin]-2-ylamino)-4-methylphenyl)-4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-3-(trifluoromethyl)benzamide
  • NS-187|||INNO-406
  • 859212-16-1
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals