Bafetinib

ChemicalBook > CAS DataBase List > Bafetinib

Product Name: Bafetinib
CAS No.: 859212-16-1
Chemical Name: Bafetinib
Synonyms: Benil;Ns 187;CS-239;Rhinon;Inno-406;Inno 406;Rinazina;Unii-nvw4Z03I9b;NS-187|||INNO-406;Bafetinib (INNO-406)
CBNumber: CB92473854
Molecular Formula: C30H31F3N8O
Formula Weight: 576.62
MOL File: 859212-16-1.mol

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Bafetinib Property

Melting point:: 166-168°C
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: DMSO:42.0(Max Conc. mg/mL);72.84(Max Conc. mM)
form: A crystalline solid
pka: 12.72±0.70(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19169
Product name: Bafetinib
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 19169
Product name: Bafetinib
Purity: ≥98%
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Cayman Chemical

Product number: 19169
Product name: Bafetinib
Purity: ≥98%
Packaging: 10mg
Price: $214
Updated: 2024/03/01

TRC

Product number: B109050
Product name: Bafetinib
Packaging: 5mg
Price: $90
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb180774
Product name: Bafetinib (INNO-406)
Purity: >98%
Packaging: 1g
Price: $2172.6
Updated: 2021/12/16

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Bafetinib Chemical Properties,Usage,Production

Description

Bcr-Abl, a fusion protein with deregulated tyrosine kinase activity, is highly expressed in chronic myelogenous leukemia (CML). Bafetinib is a rationally developed tyrosine kinase inhibitor based on the chemical structure of imatinib , with modifications added to improve binding and potency against Bcr-Abl kinase (IC₅₀ = 5.8 nM). It is 25- to 55-fold more potent than imatinib in vitro and ≥10-fold more potent in vivo. Bafetinib inhibits 12 out of the 13 most frequent imatinib-resistant Bcr-Abl point mutations, but not the T315I mutation and also targets the Src family kinase Lyn (IC₅₀ = 19 nM), which has been associated with resistance to imatinib in CML.

Chemical Properties

Pale Yellow Solid

Uses

A substituted benzamide derivative structurally related to STI-571 (Imatinib Mesylate). It was identified as highly potent Bcr-Abl kinase inhibitor.

Bafetinib Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Bafetinib manufacturers

Dideu Industries Group Limited

Product: Bafetinib 859212-16-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-06

Career Henan Chemical Co

Product: Bafetinib 859212-16-1
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-22

859212-16-1, BafetinibRelated Search:

Erlotinib Sunitinib Flumatinib mesylate Baricitinib Bortezomib Bosutinib Nilotinib Vismodegib (GDC-0449) Trametinib Ibrutinib

Benzamide, N-(3-((4,5'-bipyrimidin)-2-ylamino)-4-methylphenyl)-4-(((3S)-3-(dimethylamino)-1-pyrrolidinyl)methyl)-3-(trifluoromethyl)-

Inno 406

Inno-406

4-[[(3S)-3-Dimethylaminopyrrolidin-1-yl]methyl]-N-[4-methyl-3-[(4-pyrimidin-5-ylpyrimidin-2-yl)amino]phenyl]-3-(trifluoromethyl)benzamide

NS-187; BAFETINIB; INNO406

CS-239

INNO 406 - Bafetinib

Ns 187

Unii-nvw4Z03I9b

Bafetinib (INNO-406)

N-[3-([4,5'-BipyriMidin]-2-ylaMino)-4-Methylphenyl]-4-[[(3S)-3-(diMethylaMino)-1-pyrrolidinyl]Methyl]-3-(trifluoroMethyl)benzaMide

Bafetinib(INNO 406,NS 187)

(S)-N-(3-([4,5'-bipyriMidin]-2-ylaMino)-4-Methylphenyl)-4-((3-(diMethylaMino)pyrrolidin-1-yl)Methyl)-3-(trifluoroMethyl)benzaMide

(S)-4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-N-(4-methyl-3-(4-(pyrimidin-5-yl)pyrimidin-2-ylamino)phenyl)-3-(trifluoromethyl)benzamide

Bafetinib N-[3-([4,5'-bipyrimidin]-2-ylamino)-4-methylphenyl]-4-[[(3S)-3-(dimethylamino)-1-pyrrolidinyl]methyl]-3-(trifluoromethyl)benzamide

Benil

Rhinon

Rinazina

(S)-N-(3-([4,5'-Bipyrimidin]-2-ylamino)-4-methylphenyl)-4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-3-(trifluoromethyl)benzamide

NS-187|||INNO-406

859212-16-1

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