ChemicalBook > CAS DataBase List > Bafetinib

Bafetinib

Product Name
Bafetinib
CAS No.
859212-16-1
Chemical Name
Bafetinib
Synonyms
Benil;Ns 187;CS-239;Rhinon;Inno-406;Inno 406;Rinazina;Unii-nvw4Z03I9b;NS-187|||INNO-406;Bafetinib (INNO-406)
CBNumber
CB92473854
Molecular Formula
C30H31F3N8O
Formula Weight
576.62
MOL File
859212-16-1.mol
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Bafetinib Property

Melting point:
166-168°C
Density 
1.36±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
DMSO:42.0(Max Conc. mg/mL);72.84(Max Conc. mM)
form 
A crystalline solid
pka
12.72±0.70(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

H320Causes eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19169
Product name
Bafetinib
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
19169
Product name
Bafetinib
Purity
≥98%
Packaging
5mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
19169
Product name
Bafetinib
Purity
≥98%
Packaging
10mg
Price
$214
Updated
2024/03/01
TRC
Product number
B109050
Product name
Bafetinib
Packaging
5mg
Price
$90
Updated
2021/12/16
Biorbyt Ltd
Product number
orb180774
Product name
Bafetinib (INNO-406)
Purity
>98%
Packaging
1g
Price
$2172.6
Updated
2021/12/16
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Bafetinib Chemical Properties,Usage,Production

Description

Bcr-Abl, a fusion protein with deregulated tyrosine kinase activity, is highly expressed in chronic myelogenous leukemia (CML). Bafetinib is a rationally developed tyrosine kinase inhibitor based on the chemical structure of imatinib , with modifications added to improve binding and potency against Bcr-Abl kinase (IC50 = 5.8 nM). It is 25- to 55-fold more potent than imatinib in vitro and ≥10-fold more potent in vivo. Bafetinib inhibits 12 out of the 13 most frequent imatinib-resistant Bcr-Abl point mutations, but not the T315I mutation and also targets the Src family kinase Lyn (IC50 = 19 nM), which has been associated with resistance to imatinib in CML.

Chemical Properties

Pale Yellow Solid

Uses

A substituted benzamide derivative structurally related to STI-571 (Imatinib Mesylate). It was identified as highly potent Bcr-Abl kinase inhibitor.

in vivo

Bafetinib (30 mg/kg/day, orally, for 10 consecutive days) inhibits the expression of PD-L1 in mouse lung cancer[1].
Bafetinib (10 mg/kg, gavage, single dose) alleviates pain in mice by inhibiting PAR2-induced TRPV4 channel activation[2].

Animal Model:Murine inflammatory pain model[2]
Dosage:10 mg/kg
Administration: i.g.
Result: Inhibited PAR2-induced mechanical hyperalgesia.

References

[1] SHINYA KIMURA. NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia.[J]. Blood, 2005, 106 12: 3948-3954. DOI: 10.1182/blood-2005-06-2209

Bafetinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Bafetinib Suppliers

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View Lastest Price from Bafetinib manufacturers

Sinoway Industrial co., ltd.
Product
Bafetinib 859212-16-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20tons
Release date
2025-04-11
Dideu Industries Group Limited
Product
Bafetinib 859212-16-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-06
Career Henan Chemical Co
Product
Bafetinib 859212-16-1
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-22

859212-16-1, BafetinibRelated Search:

Flumatinib mesylate Erlotinib Sunitinib Baricitinib Bortezomib Bosutinib Nilotinib Vismodegib (GDC-0449) Trametinib Ibrutinib

  • Benzamide, N-(3-((4,5'-bipyrimidin)-2-ylamino)-4-methylphenyl)-4-(((3S)-3-(dimethylamino)-1-pyrrolidinyl)methyl)-3-(trifluoromethyl)-
  • Inno 406
  • Inno-406
  • 4-[[(3S)-3-Dimethylaminopyrrolidin-1-yl]methyl]-N-[4-methyl-3-[(4-pyrimidin-5-ylpyrimidin-2-yl)amino]phenyl]-3-(trifluoromethyl)benzamide
  • NS-187; BAFETINIB; INNO406
  • CS-239
  • INNO 406 - Bafetinib
  • Ns 187
  • Unii-nvw4Z03I9b
  • Bafetinib (INNO-406)
  • N-[3-([4,5'-BipyriMidin]-2-ylaMino)-4-Methylphenyl]-4-[[(3S)-3-(diMethylaMino)-1-pyrrolidinyl]Methyl]-3-(trifluoroMethyl)benzaMide
  • Bafetinib(INNO 406,NS 187)
  • (S)-N-(3-([4,5'-bipyriMidin]-2-ylaMino)-4-Methylphenyl)-4-((3-(diMethylaMino)pyrrolidin-1-yl)Methyl)-3-(trifluoroMethyl)benzaMide
  • (S)-4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-N-(4-methyl-3-(4-(pyrimidin-5-yl)pyrimidin-2-ylamino)phenyl)-3-(trifluoromethyl)benzamide
  • Bafetinib N-[3-([4,5'-bipyrimidin]-2-ylamino)-4-methylphenyl]-4-[[(3S)-3-(dimethylamino)-1-pyrrolidinyl]methyl]-3-(trifluoromethyl)benzamide
  • Benil
  • Rhinon
  • Rinazina
  • NS-187|||INNO-406
  • Bafetinib, 10 mM in DMSO
  • 859212-16-1
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals