5'-fluoro-2'-Iodoacetophenone

Notes

Product Name: 5'-fluoro-2'-Iodoacetophenone
CAS No.: 914225-70-0
Chemical Name: 5'-fluoro-2'-Iodoacetophenone
Synonyms: 1-(5-fluoro-2-iodophenyl)ethan-1-one;1-(5-Fluoro-2-iodophenyl)ethanone;uoro-2'-iodoacetophenone;5'-Fluoro-2'-iodoacetophenon;5-FLUORO-2-IODOACEETOPHENONE;5'-fluoro-2'-Iodoacetophenone;5'-Fluoro-2'-iodoacetophenonec;5'-Fluoro-2'-iodoacetophenone,98%;5'-Fluoro-2'-iodoacetophenone, 98%;Ethanone, 1-(5-fluoro-2-iodophenyl)-
CBNumber: CB92476022
Molecular Formula: C8H6FIO
Formula Weight: 264.04
MOL File: 914225-70-0.mol

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5'-fluoro-2'-Iodoacetophenone Property

Boiling point:: 269.5±25.0 °C(Predicted)
Density: 1.793
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Liquid
color: Brown
Water Solubility: Slightly soluble in water.
Sensitive: Light Sensitive
InChI: InChI=1S/C8H6FIO/c1-5(11)7-4-6(9)2-3-8(7)10/h2-4H,1H3
InChIKey: NRLSRIONJVBZDT-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC(F)=CC=C1I)C

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Safety

HS Code: 2914790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: F598775
Product name: 1-(5-Fluoro-2-iodophenyl)ethanone
Packaging: 2.5g
Price: $155
Updated: 2021/12/16

Matrix Scientific

Product number: 144400
Product name: 5'-Fluoro-2'-iodoacetophenone
Purity: 95%
Packaging: 1g
Price: $681
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0050627
Product name: 2'-IODO-5'-FLUOROACETOPHENONE
Purity: 95.00%
Packaging: 5G
Price: $1249.13
Updated: 2021/12/16

Matrix Scientific

Product number: 144400
Product name: 5'-Fluoro-2'-iodoacetophenone
Purity: 95%
Packaging: 5g
Price: $2043
Updated: 2021/12/16

AK Scientific

Product number: J97334
Product name: 5'-Fluoro-2'-Iodoacetophenone
Packaging: 1g
Price: $25
Updated: 2021/12/16

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5'-fluoro-2'-Iodoacetophenone Chemical Properties,Usage,Production

Notes

Light Sensitive. Incompatible with light and oxidizing agents.

Uses

5'-Fluoro-2'-iodoacetophenone is used as pharmaceutical intermediates.

Materials Uses

1-(5-Fluoro-2-iodophenyl)ethanone is a reactant in the preparation of PF-06463922, a potent macrocyclic ALK inhibitor as potential antitumor.

Synthesis

52548-63-7

105-53-3

914225-70-0

1. 5-Fluoro-2-iodobenzoic acid was dissolved in an appropriate amount of solvent, 13.87 mol/L thionyl chloride was added, heated to 60°C and the reaction was stirred overnight until complete clarification. The progress of the reaction was monitored by TLC (unfolding agent: petroleum ether/ethyl acetate=10/1). Upon completion of the reaction, the solvent was removed by evaporation, toluene was added and evaporated to dryness, and the resulting product was dissolved in ethyl acetate and set aside. 2. 3658 g of diethyl malonate was dissolved in 55 L of ethyl acetate, and 4762 g of magnesium chloride was slowly added at room temperature for 30 minutes. Subsequently 4877 g of triethylamine was added dropwise and stirring was continued for 30 minutes. The reaction mixture was cooled to 5°C in an ice bath, the organic phase was washed with saturated saline (10 L x 2) and stirred for 2 h at room temperature. The completion of the reaction was confirmed by TLC (unfolding agent: petroleum ether/ethyl acetate = 10/1). 3. The organic layer was separated and the solvent was evaporated to give a red oil. To the oily substance was added 12 L of a mixture consisting of acetic acid, water and concentrated sulfuric acid in the ratio of 6.6:4.4:1 by volume, heated to 100°C, and the reaction was stirred overnight. After completion of the reaction, the organic phase was washed with saturated saline (10 L x 2). 4. The organic phase was further washed with 0.5 N sodium hydroxide solution (30 L × 1) and saturated saline (10 L × 2). Finally, it was purified by silica gel column chromatography (unfolding agent: petroleum ether/ethyl acetate = 8/1) to give 3.6 kg of the target product 1-(5-fluoro-2-iodophenyl)ethanone.

References

[1] Patent: CN105732355, 2016, A. Location in patent: Paragraph 0024; 0030; 0034

5'-fluoro-2'-Iodoacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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5'-fluoro-2'-Iodoacetophenone Suppliers

China 189 India 5 United States 9 Global 203

Hangzhou Chemtrue Bio-Tech Co.,Ltd.

Tel: 0571-86828652 18857119830
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Block Chemical Technology (Shanghai) Co., LTD

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Energy Chemical

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Energy Chemical

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ChengDu TongChuangYuan Pharmaceutical Co.Ltd

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Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
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Shanghai Longsheng chemical Co.,Ltd.

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View Lastest Price from 5'-fluoro-2'-Iodoacetophenone manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 5'-fluoro-2'-Iodoacetophenone 914225-70-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD

Product: 5'-fluoro-2'-Iodoacetophenone 914225-70-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 500 kgs
Release date: 2024-07-08

Nanjing Fred Technology Co., Ltd

Product: 1-(5-Fluoro-2-iodophenyl)ethanone 914225-70-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-29

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914225-70-0

C8H6FIO

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