Domperidone maleate

Product Name: Domperidone maleate
CAS No.: 99497-03-7
Chemical Name: Domperidone maleate
Synonyms: DOMEPRIDONE MALEATE;DOMPERIDONE MALEATE;E-Domperidone Maleate;Domperidone Maleate IP/BP/Ph. Eur;6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one;(E)-but-2-enedioic acid,6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one;5-chloro-1-[1-[3-(2-oxo-1,3-dihydrobenzoimidazol-1-yl)propyl]-4-piperidyl]-1,3-dihydrobenzoimidazol-2-one maleate;2H-Benzimidazol-2-one, 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-, (Z)-2-butenedioate;Domperidone maleateQ: What is Domperidone maleate Q: What is the CAS Number of Domperidone maleate Q: What is the storage condition of Domperidone maleate
CBNumber: CB9247961
Molecular Formula: C26H28ClN5O6
Formula Weight: 541.99
MOL File: 99497-03-7.mol

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Domperidone maleate Property

storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: Very slightly soluble in water, sparingly soluble in dimethylformamide, slightly soluble in methanol, very slightly soluble in ethanol (96 per cent).
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: D531115
Product name: Domperidone maleate
Packaging: 5mg
Price: $8250
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007069
Product name: DOMPERIDONE MALEATE
Purity: 95.00%
Packaging: 100MG
Price: $885.31
Updated: 2021/12/16

AK Scientific

Product number: S484
Product name: Domperidone maleate
Packaging: 5mg
Price: $39
Updated: 2021/12/16

AK Scientific

Product number: S484
Product name: Domperidone maleate
Packaging: 25mg
Price: $88
Updated: 2021/12/16

AK Scientific

Product number: S484
Product name: Domperidone maleate
Packaging: 100mg
Price: $195
Updated: 2021/12/16

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Domperidone maleate Chemical Properties,Usage,Production

Description

Domperidone maleate is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.

Chemical Properties

Domperidone maleate occurs as a white or almost white powder that exhibits polymorphism. It is very slightly soluble in water or alcohol.

Uses

Domperidone maleate (CAS# 99497-03-7); a form of Domperidone (D531100), a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.

Preparation

Domperidone was synthesized at Janssen Pharmaceutica in 1974 following their research on antipsychotic drugs. The present invention relates to synthesis of domperidone maleate. O-diaminobenzene is first cyclized and halogenated to form the first benzimidazolone intermediate; 1-carbethoxy-4-amino piperidine is halogenated, reduced, cyclized and hydrolyzed to form the second benzimidazolone intermediate; the two benzimidazolone intermediates are reacted to produce domperidone; and domperidone is finally reacted with maleic aicd to produce domperidone maleate.
https://patents.google.com/patent/CN1810805A/en

Indications

Domperidone may be useful for treatment of fescue toxicosis in pregnant mares or as a prokinetic or antiemetic agent in small animals. It has more effect on conditions with delayed gastric emptying than other GI hypomotility conditions. Via its effects on prolactin, domperidone may also be used to stimulate milk production in horses and small animals. Domperidone has been shown to increase plasma ACTH in horses with equine pituitary pars intermedia dysfunction (Equine Cushing’s) and may be useful in helping diagnose this condition.

Side effects

Because plasma prolactin levels may be increased, galactorrhea or gynecomastia may result. Injectable products (now withdrawn) have been associated with arrhythmias in human patients with heart disease or hypokalemia. Rarely, somnolence or dystonic reac- tions have occurred in people.

Domperidone maleate Preparation Products And Raw materials

Raw materials

Preparation Products

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Domperidone maleate Suppliers

China 54 Europe 1 France 1 Germany 2 India 11 South Korea 1 United Kingdom 1 United States 6 Global 77

INTATRADE GmbH

Tel: +49 3493/605464
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3B Pharmachem (Wuhan) International Co.,Ltd.

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UHN Shanghai Research & Development Co., Ltd.

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Wuhan Dahua Pharmaceutical Co., Ltd.

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Nanjing Duolong Bio-tech Co.,Ltd.

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Jai Radhe Sales

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Amadis Chemical Company Limited

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Wuhan Wsem Biological Co., Ltd.

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Wellman Pharmaceutical Group Limited

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Fax: 027-83991220
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Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-28967200 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
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View Lastest Price from Domperidone maleate manufacturers

Career Henan Chemical Co

Product: Domperidone maleate 99497-03-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 683
Release date: 2019-09-01

99497-03-7, Domperidone maleateRelated Search:

Domperidone Epichlorohydrin Allyl chloride Benzimidazole Enalapril maleate Propyl butyrate Chloromethyl isopropyl carbonate Tetrapropylammonium hydroxide Phenformin 5-Chloro-1-(4-piperidyl)-2-benzimidazolinone Disodium fumarate Propyl gallate DoMperidone EP IMpurity B DoMperidone-d6 Domperidone Impurity 15 1-(3-chloropropyl)-1,3-dihydro-3-(1-methylvinyl)-2H-benzimidazol-2-one 1-(3-BroMopropyl)-1,3-dihydro-2H-benziMidazol-2-one 1-PIPERIDINECARBOXYLIC ACID, 4-[(4-AMINO-5-CHLOROPHENYL)AMINO], ETHYL ESTER

DOMPERIDONE MALEATE

5-chloro-1-[1-[3-(2-oxo-1,3-dihydrobenzoimidazol-1-yl)propyl]-4-piperidyl]-1,3-dihydrobenzoimidazol-2-one maleate

2H-Benzimidazol-2-one, 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-, (Z)-2-butenedioate

E-Domperidone Maleate

6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one

(E)-but-2-enedioic acid,6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one

Domperidone maleateQ: What is Domperidone maleate Q: What is the CAS Number of Domperidone maleate Q: What is the storage condition of Domperidone maleate

Domperidone Maleate IP/BP/Ph. Eur

DOMEPRIDONE MALEATE

99497-03-7

C22H24ClN5O2C4H4O4

C26H28ClN5O6