6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

Product Name: 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
CAS No.: 1231930-33-8
Chemical Name: 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
Synonyms: 6-Bromo-4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazole;Abemaciclib Impurity 1;Abemaciclib Impurity N4;Abemaciclib Impurity 1 D5;Abemaciclib Impurity 1 D12;6-bromo-4-fluoro-2-methyl-1-(1-methylethyl)-;6-Bromo-4-fluoro-1-isopropyl-2-methylbenzimidazole;6-bromo-4-fluoro-2-methyl-1-propan-2-ylbenzimidazole;6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole;6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
CBNumber: CB92500134
Molecular Formula: C11H12BrFN2
Formula Weight: 271.13
MOL File: 1231930-33-8.mol

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6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole Property

Boiling point:: 353.4±22.0 °C(Predicted)
Density: 1.49
storage temp.: Sealed in dry,Room Temperature
pka: 3.48±0.10(Predicted)
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C11H12BrFN2/c1-6(2)15-7(3)14-11-9(13)4-8(12)5-10(11)15/h4-6H,1-3H3
InChIKey: SJQZRZLUEGCXFN-UHFFFAOYSA-N
SMILES: C1(C)N(C(C)C)C2=CC(Br)=CC(F)=C2N=1

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B692398
Product name: 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1h-benzo[d]imidazole
Packaging: 500mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 090163
Product name: 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
Purity: 95+%
Packaging: 1g
Price: $89
Updated: 2021/12/16

AK Scientific

Product number: X9551
Product name: 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
Packaging: 1g
Price: $158
Updated: 2021/12/16

Apolloscientific

Product number: PC28238
Product name: 6-Bromo-4-fluoro-1-isopropyl-2-methyl-benzimidazole
Packaging: 1g
Price: $235
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-B-4L
Product name: 6-Bromo-4-fluoro-1-isopropyl-2-methylbenzimidazole
Packaging: 1g
Price: $376
Updated: 2021/12/16

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6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole Chemical Properties,Usage,Production

Uses

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole is a pharmaceutical intermediate. It can be used in the preparation of Abemaciclib, a kinase inhibitor for the treatment of adult patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer who have experienced disease progression following endocrine therapy and prior chemotherapy.

Flammability and Explosibility

Not classified

Synthesis

1231930-29-2

1231930-33-8

The general procedure for the synthesis of 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[D]imidazole using (E)-N-(4-bromo-2,6-difluorophenyl)-N'-isopropylacetamidine as starting material was as follows: potassium tert-butanolate (6.9 kg) was added batchwise to a (E)-N-(4-bromo-2,6-difluorophenyl)-N'-isopropylacetamidine (16.2 kg) N-methylformamide (76 kg) solution while controlling the reaction temperature below 30°C. The reaction mixture was heated to 70-75°C until the completion of the reaction was monitored by HPLC. The reaction solution was then cooled to 20-30°C and the reaction was quenched by addition of water (227 kg). Extraction was carried out with methyl tert-butyl ether (37 x 4 kg) and the combined organic phases were washed with brine (49 x 2 kg). The organic phase was concentrated to 25-30 L, n-hexane (64 kg) was added and the resulting slurry was filtered to give 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[D]imidazole (11 kg). Mass spectrum (ES+): m/z = 272 (M + H)+. For further purification, the crude product was dissolved in dichloromethane, filtered through silica gel and Celite pads, and finally recrystallized from a mixed solvent of methyl tert-butyl ether/hexane.

References

[1] Patent: US2010/160340, 2010, A1. Location in patent: Page/Page column 10
[2] Patent: WO2015/130540, 2015, A1. Location in patent: Page/Page column 22

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole Suppliers

China 232 India 7 United Kingdom 1 United States 6 Global 246

BTC pharm India

Tel: +918790379245
Email: banny.janga@btcpharm.com
Country: India
ProdList: 1262
Advantage: 58

SynZeal Research Pvt Ltd

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Email: standards@synzeal.com
Country: India
ProdList: 6514
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A.J Chemicals

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Email: sales@ajchem.in
Country: India
ProdList: 6100
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View Lastest Price from 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 1231930-33-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-28

Shaanxi Dideu New Materials Co. Ltd

Product: 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 1231930-33-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-11

Henan Aochuang Chemical Co.,Ltd.

Product: 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 1231930-33-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

1231930-33-8, 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazoleRelated Search:

6-BroMo-4-fluoro-3-Methylindazole PERFLUOROPOLYALKYL ETHER GALDEN (TM) HT70 Hexafluoroisopropyl methyl ether 1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- 2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one PF-01367338 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine 4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)benzaldehyde 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

6-Bromo-4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazole

1H-BenziMidazole, 6-broMo-4-fluoro-2-Methyl-1-(1-Methylethyl)-

6-bromo-4-fluoro-2-methyl-1-propan-2-ylbenzimidazole

6-bromo-4-fluoro-2-methyl-1-(propan-2-yl)-1H-1,3-benzodiazole

6-Bromo-4-fluoro-1-isopropyl-2-methylbenzimidazole

Abemaciclib Impurity 1

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole ISO 9001：2015 REACH

Abemaciclib Impurity 1 D12

Abemaciclib Impurity 1 D5

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole

6-bromo-4-fluoro-2-methyl-1-(1-methylethyl)-

5-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

5-bromo-7-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

Abemaciclib Impurity N4

1231930-33-8

1230930-33-8

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