Dabigatran Etexilate Mesylate

Product Name: Dabigatran Etexilate Mesylate
CAS No.: 872728-81-9
Chemical Name: Dabigatran Etexilate Mesylate
Synonyms: Pradaxa;Pradaxa Mesylate;Dabigatran mesylate;Dabigatran Etexilate Mesylate API;Ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-;Hexyl 2-(4-(((5-((3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbaMoyl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)Methyl)aMino)benzylidene)hydrazinecarboxylate Methanesulfonate;ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate methanesulfonate;(E)-hexyl 2-(4-((5-((3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbaMoyl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)MethylaMino)benzylidene)hydrazinecarboxylate Methanesulfonate;N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester monomethanesulfonat;Dabig
CBNumber: CB92500679
Molecular Formula: C35H45N7O8S
Formula Weight: 723.85
MOL File: 872728-81-9.mol

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Dabigatran Etexilate Mesylate Property

Melting point:: >125°C
storage temp.: Refrigerator
solubility: DMSO (Slightly, Heated), Methanol (Slightly)
form: Solid
color: White to Pale Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H413May cause long lasting harmful effects to aquatic life

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N-Bromosuccinimide Price

Usbiological

Product number: 007470
Product name: Dabigatran Etexilate Mesylate
Packaging: 10mg
Price: $425
Updated: 2021/12/16

ApexBio Technology

Product number: A3345
Product name: Dabigatranetexilatemesylate
Packaging: 100mg
Price: $523
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD20773
Product name: Dabigatran etexilate mesylate
Packaging: 2g
Price: $340
Updated: 2021/12/16

ApexBio Technology

Product number: A3345
Product name: Dabigatranetexilatemesylate
Packaging: 50mg
Price: $361
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD20773
Product name: Dabigatran etexilate mesylate
Packaging: 100mg
Price: $65
Updated: 2021/12/16

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Dabigatran Etexilate Mesylate Chemical Properties,Usage,Production

Description

Dabigatran etexilate mesylate is a clinical direct thrombin inhibitor and a new type of oral anticoagulant. It can inhibit the formation of thrombus by reversibly and potently competing with the fibrin-specific binding site of thrombin to block fibrin generation.

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Nonpeptide, direct thrombin inhibitor. Antithrombotic.

Clinical Use

Dabigatran Etexilate Mesylate is a direct thrombin inhibitor indicated to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.

Definition

ChEBI: A methanesulfonate salt obtained by reaction of dabigatran etexilate with one equivalent of dabigatran etexilate. A prodrug for dabigatran, a thrombin inhibitor and anticoagulant which is used for the prevention of stroke and systemic embolism.

Biological Activity

Dabigatran etexilate mesylate (BIBR 1048MS) is an orally active prodrug of Dabigatran. Dabigatran etexilate mesylate has anticoagulant properties and can prevent venous thromboembolism and stroke due to atrial fibrillation.

Mechanism of action

Dabigatran etexilate mesylate is a prodrug of dabigatran that is metabolized in the body and converted to the active dabigatran. Compared with warfarin, dabigatran etexilate mesylate does not require frequent monitoring of coagulation function and dose adjustment during treatment, and there are fewer interactions between drugs and is not affected by eating, thus improving patients' medication compliance.

Side effects

The most common adverse reactions to Dabigatran Etexilate Mesylate (150 mg) were bleeding and gastrointestinal events (i.e. dyspepsia, nausea, epigastric pain, gastrointestinal bleeding, and diarrhoea). Very few patients experienced drug hypersensitivity (including urticaria, rash and pruritus), anaphylactic oedema, anaphylactic reactions and anaphylaxis.

in vivo

Dabigatran etexilate mesylate (BIBR 1048MS; oral; 10, 20 and 50 mg/kg for rats and 1, 2.5 and 5 mg/kg for monkeys) has dose- and time-dependent anticoagulant effects and has maximum effects between 30 and 120 min after administration, respectively.Dabigatran etexilate mesylate maximally and significantly prolongs partial thromboplastin time (aPTT) to 25.2, 38.4 and 78.3 s in 30 min after 10, 20 and 50 mg/kg oral doses, respectively.Dabigatran etexilate mesylate maximally prolongs the aPTT to 34.3 s, 44.0 s, and 63.0 s, respectively, 2h after 1, 2.5 or 5 mg/kg doses in the monkey.

Dabigatran Etexilate Mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Dabigatran Etexilate Mesylate Suppliers

Canada 2 China 370 Germany 1 India 54 Israel 1 Poland 1 Singapore 1 Spain 1 United Kingdom 3 United States 18 Global 452

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View Lastest Price from Dabigatran Etexilate Mesylate manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: Dabigatran Etexilate Mesylate 872728-81-9
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000kg
Release date: 2024-05-13

Hebei Saisier Technology Co., LTD

Product: Dabigatran Etexilate Mesylate 872728-81-9
Price: US $6.00/KG
Min. Order: 1KG
Purity: More than 99%
Supply Ability: 2000KG/Month
Release date: 2024-05-10

Henan Fengda Chemical Co., Ltd

Product: Dabigatran Etexilate Mesylate 872728-81-9
Price: US $10.00-3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-26

872728-81-9, Dabigatran Etexilate MesylateRelated Search:

5-(2-Bromoethyl)-2,3-dihydrobenzofuran 3-(S)-(+)-(1-Carbamoyl-1,1-diphenylmethyl)pyrroloidine-L-(+)-tartarate Dabigatran Etexilate iMpurity 4 Dabigatran Etexilate iMpurity 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester N-(4-CYANO-PHENYL)-GLYCINE Chloroacetic anhydride 4-Aminobenzamidine dihydrochloride 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER HEXYL CHLOROFORMATE N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-beta-alanine ethyl ester hydrochloride Dabigatran Etexilate iMpurity D Dabigatran iMpurity E Des-(N-2-pyridyl-β-alanine Ethyl Ester) Dabigatran Etexilate 5-Ethyl Carboxylate (Dabigatran IMpurity) Dabigatran iMpurity F Dabigatran etexilate Dabigatran

Dabigatran etexilate mesylate

(Z)-ethyl 3-(2-(((4-(N'-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate methanesulfonate

Ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-

Dabigatran etexilate mesylate,Pradaxa

ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate methanesulfonate

Dabigatran Mesylate Reference

Dabigatran mesylate

N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester monomethanesulfonat supplier in Chin

CS-900

3-([2-[[(4-(N-n-hexyloxycarbonylcarbamimidoyl)-phenylamino)-methyl]]-1-methyl-1H-benzimidazole-5-carbonyl]-pyridin-2-yl-amino)ethyl propionate mesylate

PRADAXA; BIBR 1048MS; DABIGATRAN ETEXILATE METHANESULFONATE

N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester monomethanesulfonat

Pradaxa

Dabigatran etexilate Mesylate 872728-81-9

[[[(Hexyloxy)carbonyl]aMino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanineethylesterMonoMethanesulfonat

Hexyl 2-(4-(((5-((3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbaMoyl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)Methyl)aMino)benzylidene)hydrazinecarboxylate Methanesulfonate

(E)-hexyl 2-(4-((5-((3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbaMoyl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)MethylaMino)benzylidene)hydrazinecarboxylate Methanesulfonate

N-[[2-[[[4-[[[(Hexyloxy)carbonyl]aMino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-y

BIBR 1048MS

N-[[2-[[[4-[[[(Hexyloxy)carbonyl]aMino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine Ethyl Ester Methanesulfonate

Dabigatran etexilate Methanesulfonate

Pradaxa Mesylate

ate MesyL

atran EtexiL

Dabig

Dabigatran EtexiL

Dabigatran Etexilate Mesylate USP/EP/BP

Dabigatran Etexilate Mesylate Pellet

Dabigatran Etexilate Mesylate- IH

B-Alanine, N-[[2-[[[4-[[[(hexyloxy) carbonyl] amino] iminomethyl] phenyl] amino] methyl]-1-methyl-1H-benzimidazol-5-yl] carbonyl]-N-2-pyridinyl -,ethyl ester, methanesulfonate

N-[[2-[[[4-[[[(Hexyloxy)carbonyl] amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine ethyl ester methanesulfonate

Dabigatran Etexilate MesylateQ: What is Dabigatran Etexilate Mesylate Q: What is the CAS Number of Dabigatran Etexilate Mesylate Q: What is the storage condition of Dabigatran Etexilate Mesylate Q: What are the applications of Dabigatran Etexilate Mesylate

Dabigatran Etexilate Mesylate API

Dabigatran etexilatemesi

Pradaxa, Dabigatran etexilate mesylate

872728-81-9

C34H41N7O5CH4O3S

C35H45N7O8S

Aromatics

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Heterocycles

Intermediates & Fine Chemicals

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Pharmaceuticals

Dabigatran etexilate mesylate

API

872728-81-9