ChemicalBook > CAS DataBase List > D-AMPHETAMINE SULFATE

D-AMPHETAMINE SULFATE

Product Name
D-AMPHETAMINE SULFATE
CAS No.
51-63-8
Chemical Name
D-AMPHETAMINE SULFATE
Synonyms
dexamphetamine sulphate;tydex;amdex;ardex;dadex;medex;zamine;afatin;amphex;dexten
CBNumber
CB9250435
Molecular Formula
C18H28N2O4S
Formula Weight
368.49
MOL File
51-63-8.mol
More
Less

D-AMPHETAMINE SULFATE Property

Melting point:
>300°
alpha 
D20 +21.8° (c = 2)
Density 
1.1500
refractive index 
1.6930 (estimate)
storage temp. 
Desiccate at RT
solubility 
H2O: soluble
form 
Powder
color 
Plates
Water Solubility 
Soluble to 100 mM in water
Stability:
Stable. Incompatible with strong oxidizing agents.
EPA Substance Registry System
Benzeneethanamine, .alpha.-methyl-, (.alpha.S)-, sulfate (2:1) (51-63-8)
More
Less

Safety

Hazard Codes 
T,F
Risk Statements 
25-39/23/24/25-23/24/25-11
Safety Statements 
45-36/37-16
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
SI1400000
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
2921460000
Toxicity
LD50 orally in mice: 10 mg/kg (Warawa)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

D-AMPHETAMINE SULFATE Chemical Properties,Usage,Production

Chemical Properties

white powder

Originator

Dexedrine Sulfate,SKF,US,1944

Uses

Amfetamine

Manufacturing Process

Two mols, for example, 270 grams, of racemic α-methylphenethylamine base are reacted with one mol (150 grams) of d-tartaric acid, thereby forming dl-αmethylphenethylamine d-tartrate, a neutral salt. The neutral salt thus obtained is fully dissolved by the addition of sufficient, say about 1 liter, of absolute ethanol, and heating to about the boiling point. The solution is then allowed to cool to room temperature with occasional stirring to effect crystallization. The crystals are filtered off and will be found to contain a preponderance of the levo enantiomorph.
The residual solid in the mother liquors is repeatedly and systematically crystallized, yielding a further fraction of 1-α-methylphenethylamine d-tartrate which may be purified by recrystallization. d-α-Methylphenethylamine may be readily recovered from the mother liquors by the addition of tartaric acid thereto for the formation of acid tartrates and separation of d-αmethylphenethylamine d-bitartrate by crystallization.
The free base of either optical isomer may be obtained by addition to the dtartrate in the case of the levo isomer and the d-bitartrate in the case of the dextro isomer of alkali in excess, as, for example, by the addition of an aqueous solution of caustic soda, which will cause the base to separate as an oil which may be recovered and purified by any well-known procedure. The base is exactly neutralized with sulfuric acid to give the sulfate.

Therapeutic Function

Central stimulant

Biological Activity

CNS stimulant. Targets monoamine transporters to elevate synaptic levels of noradrenalin, dopamine and serotonin.

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. A human teratogen that causes developmental abnormalities of the central nervous system. Experimental reproductive effects including other teratogenic effects. A habit-forming stimulant. When heated to decomposition it emits very toxic fumes of SO, and NO,. See also other benzidrine compounds and SULFATES.

storage

Desiccate at RT

D-AMPHETAMINE SULFATE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

D-AMPHETAMINE SULFATE Suppliers

51-63-8, D-AMPHETAMINE SULFATERelated Search:


  • D-AMPHETAMINE SULFATE
  • (+)-alpha-methylphenethylaminesulfate(2:1)
  • (+)-amitrene
  • (+)-amphetaminesulfate
  • acedron
  • tydex
  • zamine
  • D-amphetamine sulfate methanol*solution-1mg per M
  • D-amphetamine sulfate--dea schedule*ii item
  • dexamphetamine sulphate
  • S(+)-AMPHETAMINE SULFATE (DEXTROAMPHETAM INE SU
  • D-AMPHETAMINE SULFATE METHANOLSOLUTION-1 MG PER ML
  • DELTA-AMPHETAMINESULPHATE
  • (+)-alpha-methylphenethylamine sulfate
  • (+)-α-Methylphenethylamine sulfate salt, Dextroamphetamine sulfate salt
  • D-Amphetamine sulfate salt
  • (S)-.alpha.-Methylbenzeneethanamine sulfate
  • .alpha.-Methyl-, sulfate,(+)
  • Benzeneethanamine, .alpha.-methyl-, (.alpha.S)-, sulfate (2:1)
  • d-amphetamine sulfate salt solution
  • adjudets
  • adrizine
  • afatin
  • albemap
  • algo-dex
  • alpha-methyl-,sulfate(2:1),(+)-phenethylamin
  • alpha-methyl-benzeneethanamin(s)-benzeneethanaminsulfate(2:1)
  • alpha-methylbenzeneethanaminesulfate
  • alpha-methylphenethylaminesulfate,d-form
  • amdex
  • Amphetaminesulfate
  • amphetasul
  • amphex
  • amsustain
  • ardex
  • Benzeneethanamine,.alpha.-methyl-,(S)-,sulfate(2:1)
  • betafedrina
  • carrtime
  • d-1-phenyl-2-aminopropanesulfate
  • dadex
  • d-alpha-methylphenethylaminesulfate
  • d-amphetaminesulphate
  • d-atephenyl747
  • d-benzedrinesulfate
  • d-betaphedrine
  • d-beta-phenylisopropylaminesulfate
  • dellipsoids
  • dephadren
  • dexalme
  • dexalone
  • dexamfetaminesulfate
  • dexamphetaminesulfate
  • dexedrinesulfate
  • dexten
  • dextro-1-phenyl-2-amino-propanesulfate
  • dextro-alpha-methylphenethylaminesulfate
  • dextroamphetaminesulfate
  • dextro-beta-phenylisopropylaminesulfate