ChemicalBook > CAS DataBase List > TEBIPENEM PIVOXIL

TEBIPENEM PIVOXIL

Product Name: TEBIPENEM PIVOXIL
CAS No.: 161715-24-8
Chemical Name: TEBIPENEM PIVOXIL
Synonyms: ME1211;TBM-PI;TBPM-PI;SPR-994;OrapeneM;TebipeneM pivoxi;Taibipeinan ester;Tebipenem Pivoxil;Tebipenem Pivoxil-d4;Tebipenem pivoxil(L-084)
CBNumber: CB92504662
Molecular Formula: C22H31N3O6S2
Formula Weight: 497.63
MOL File: 161715-24-8.mol

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TEBIPENEM PIVOXIL Property

Melting point:: 140-142℃
Boiling point:: 661.9±65.0 °C(Predicted)
Density: 1.50
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 14.36±0.20(Predicted)
form: Solid
color: White
InChIKey: SNUDIPVBUUXCDG-QHSBEEBCSA-N
SMILES: N12[C@@]([H])([C@@H]([C@H](O)C)C1=O)[C@@H](C)C(SC1CN(C3=NCCS3)C1)=C2C(OCOC(=O)C(C)(C)C)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2846
Product name: Tebipenem pivoxil
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $96.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2846
Product name: Tebipenem pivoxil
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $372.4
Updated: 2025/07/31

TRC

Product number: T012900
Product name: TebipenemPivoxil
Packaging: 100mg
Price: $1210
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb134387
Product name: Tebipenem pivoxil(L-084)
Purity: >99%
Packaging: 1g
Price: $1654.1
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 67138
Product name: TebipenemPivoxil
Packaging: 100mg
Price: $2000
Updated: 2021/12/16

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TEBIPENEM PIVOXIL Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Tebipenem Pivoxil is an oral carbapenem antibiotic. Tebipenem Pivoxil is absorbed and metabolized into Tebipenem, its active metabolite which showed excellent bactericidal activity against β-lactamase-nonproducing, ampicillin-resistant isolates.

Uses

Tebipenem pivoxil(L-084) is a novel oral carbapenem antibiotic with an IC50 of 100 μg/ml for human CYP isoforms. In mouse, rat, dog and monkey, TBPM-PI were absorbed quickly, and the bioavailability was (71.4, 59.1, 34.8 and 44.9%, respectively. There was

Definition

ChEBI: Tebipenem pivoxil is a member of carbapenems and a pivaloyloxymethyl ester.

Biological Activity

Tebipenem pivoxil (L-084I; ME1211; SPR994; Tebi-pivoxil; TBM-PI) corresponds to the orally bioavailable pivalyl ester prodrug form of the carbapenem class broad-spectrum β-lactam antibiotic Tebipenem (LJC 11,036; SPR859; TBM). TBM is potent against both gram-positive and gram-negative bacteria, including penicillin-resistant S. pneumoniae (PRSP) and many β-lactamase-producing strains, while being less effective against methicillin-resistant S. aureus (MRSA), S. marcescens, and P. aeruginosa. TBM is 2- to 64-fold more potent than imipenem, cefdinir, and faropenem against clinical isolates from respiratory and urinary-tract infections.

in vivo

Tebipenem pivoxil (L084) (0-4.00 g/kg; p.o.; once) shows minimal lethal dosage (MLD) of 4.00 g/kg and the maximum tolerance dosage (MTD) of 3.40 g/kg in mice^[1].
Tebipenem pivoxil (50 and 100 mg/kg; p.o.; once) significantly protects the sepsis mice challenged with various pathogenic bacteria^[1].

Animal Model:	KM mice weighing 18–22 g^[1]
Dosage:	2.89, 3.40 and 4.00 g/kg
Administration:	Oral administration (tablet), once
Result:	Within the 14-day observation period, only one mouse was dead in the maximum oral dosage (4.00 g/kg). The minimal lethal dosage (MLD) was 4.00 g/kg and the maximum tolerance dosage (MTD) in the mice was 3.40 g/kg. Showed dose-dependent liver and kidney damage.

Animal Model:	ICR mice, sepsis mouse models^[1]
Dosage:	50 and 100 mg/kg
Administration:	Oral administration (tablet), once
Result:	Significantly increased the survival number of the sepsis mice within a 168 h observation period.

IC 50

β-lactam

TEBIPENEM PIVOXIL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from TEBIPENEM PIVOXIL manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: TEBIPENEM PIVOXIL 161715-24-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-11-20

Wuhan JiyunZen Tech Co., Ltd.

Product: Tebipenem Pivoxil 161715-24-8
Price: US $5.00-0.50/KG
Min. Order: 0.10000000149011612KG
Purity: 99% hplc
Supply Ability: 5000kg
Release date: 2025-05-16

Wuhan JiyunZen Tech Co., Ltd.

Product: TEBIPENEM PIVOXIL 161715-24-8
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-05-14

161715-24-8, TEBIPENEM PIVOXILRelated Search:

Imipenem Biapenem Cefpirome sulfate 2,2'-[Dithiobis(3,1-azetidinediyl)]bis[4,5-dihydrothiazole] RCIMVZWCHLOZJH-RRCSTGOVSA-N Tebipenem Tebipenem Pivoxil Impurity 12 3-Hydroxy-1-(1,3-thiazolin-2-yl)azetidine S-Azetidin-3-yl ethanethioate HCl Fenasi AT7519 Saracatinib GO 6976 Ibrutinib LY2811376 Afatinib

(1R,5S,6S)-6-[1(R)-Hydroxyethyl]-1-methyl-2-[1-(2-thiazolin-2-yl)azetidin-3-ylsulfanyl]-1-carba-2-penem-3-carboxylic acid pivaloyloxymethyl ester

Tebipenem Pivoxil

[(2,2-Dimethylpropanoyl)oxy]methyl (4R,5S,6S)-3-{[1-(4,5-dihydro-1,3-thiazol-2-yl)azetidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

(4R,5S,6S)-3-[[1-(4,5-Dihydro-2-thiazolyl)-3-azetidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-Methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid (2,2-DiMethyl-1-oxopropoxy)Methyl Ester

[4R-[4α,5β,6β(R*)]]-3-[[1-(4,5-Dihydro-2-thiazolyl)-3-azetidinyl]thio]-6-(1-hydroxyethyl)-4-Methyl-7-oxo-1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid (2,2-DiMethyl-1-oxopropoxy)Methyl Ester

OrapeneM

ME1211

TBPM-PI

1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylicacid,3-[[1-(4,5-dihydro-2-thiazolyl)-3-azetidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-Methyl-7-oxo-,(2,2-diMethyl-1-oxopropoxy)Methyl ester, (4R,5S,6S)-

Taibipeinan ester

(4R,5S,6S)-pivaloyloxymethyl 3-(1-(4,5-dihydrothiazol-2-yl)azetidin-3-ylthio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate

TebipeneM pivoxi

Tebipenem pivoxil(L-084)

SPR-994

Tebipenem Pivoxil-d4

TEBIPENEM PIVOXIL USP/EP/BP

(1R,5S,6S)-6-[1(R)-Hydroxyethyl]-1-methyl-2-[1-(2-thiazolin-...

Tebipenem pivoxilQ: What is Tebipenem pivoxil Q: What is the CAS Number of Tebipenem pivoxil Q: What is the storage condition of Tebipenem pivoxil Q: What are the applications of Tebipenem pivoxil

(4R,5S,6S)-3-{[1-(4,5-dihydro-1,3-thiazol-2-yl)azetidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carbonyloxy]methyl 2,2-dimethylpropanoate

TBM-PI

Tebipenem Pivoxil, 10 mM in DMSO

161715-24-8

Inhibitors

API