4-METHOXYPHENYLACETYL CHLORIDE
- Product Name
- 4-METHOXYPHENYLACETYL CHLORIDE
- CAS No.
- 4693-91-8
- Chemical Name
- 4-METHOXYPHENYLACETYL CHLORIDE
- Synonyms
- p-Anisylacetyl chloride;4-Methoxyphenacetyl chloride;p-Methoxyphenacetyl chloride;4-METHOXYPHENYLACETYL CHLORIDE;p-Methoxyphenylacetyl chloride;4-METHOXYBENZENEACETYL CHLORIDE;4-methoxyphenyl-acetic chloride;Benzeneacetyl chloride, 4-methoxy-;4-Methoxyphenylacetyl chloride,98%;4-METHOXYPHENYLACETYL CHLORIDE 98%
- CBNumber
- CB9251609
- Molecular Formula
- C9H9ClO2
- Formula Weight
- 184.62
- MOL File
- 4693-91-8.mol
4-METHOXYPHENYLACETYL CHLORIDE Property
- Boiling point:
- 143 °C10 mm Hg(lit.)
- Density
- 1.208 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.54(lit.)
- Flash point:
- >230 °F
- storage temp.
- Inert atmosphere,2-8°C
- form
- Liquid
- color
- Clear light yellow
- Sensitive
- Moisture Sensitive
- BRN
- 908061
- CAS DataBase Reference
- 4693-91-8(CAS DataBase Reference)
Safety
- Hazard Codes
- C
- Risk Statements
- 14-34-37
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- F
- 8-10
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29189900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M945243
- Product name
- 2-(4-Methoxyphenyl)acetylchloride
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 281877
- Product name
- 4-Methoxyphenylacetyl chloride
- Packaging
- 10g
- Price
- $359
- Updated
- 2021/12/16
- Product number
- API0001262
- Product name
- 4-METHOXY PHENYL ACETYL CHLORIDE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1183.4
- Updated
- 2021/12/16
- Product number
- A646126
- Product name
- 4-Methoxyphenylacetyl chloride
- Purity
- 98%
- Packaging
- 1g
- Price
- $19
- Updated
- 2021/12/16
- Product number
- CD12070177
- Product name
- 2-(4-Methoxyphenyl)acetylchloride
- Purity
- 98%
- Packaging
- 5g
- Price
- $40
- Updated
- 2021/12/16
4-METHOXYPHENYLACETYL CHLORIDE Chemical Properties,Usage,Production
Chemical Properties
clear light yellow liquid
Uses
4-Methoxyphenylacetyl chloride may be used in the synthesis of:
- substituted spiro[4.5]decane
- 1-(4′-hydroxybenzyl)-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline (higenamine), a cardiotonic principle of aconite root
- 2,5-naphthyridine
- (R)-(+)-nor-roefractine
Synthesis
104-01-8
4693-91-8
The general procedure for the synthesis of 4-methoxyphenylacetyl chloride from 4-methoxyphenylacetic acid was as follows: 16.62 g (0.1 mol) of 4-methoxyphenylacetic acid was dissolved in 10 mL of benzene, followed by the slow addition of 29 mL (0.2 mol) of thionyl chloride to the solution. The reaction mixture was heated to reflux temperature and stirred continuously for 1 hour under this condition. Upon completion of the reaction, the residual thionyl chloride in the reaction solution and the concentrated solvent were removed by distillation under reduced pressure to afford 4-methoxybenzeneacetyl chloride (Compound I) as a liquid phase product in quantitative yield. The obtained product can be used for subsequent reaction without further purification.
References
[1] European Journal of Medicinal Chemistry, 2005, vol. 40, # 8, p. 764 - 771
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 22, p. 6160 - 6163
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 10, p. 2899 - 2903
[4] Patent: WO2005/92896, 2005, A1. Location in patent: Page/Page column 27
[5] Chinese Chemical Letters, 2013, vol. 24, # 8, p. 673 - 676
4-METHOXYPHENYLACETYL CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
4-METHOXYPHENYLACETYL CHLORIDE Suppliers
- Tel
- --
- Fax
- --
- fo@acros.com
- Country
- Belgium
- ProdList
- 3824
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@acros.com
- Country
- Belgium
- ProdList
- 6772
- Advantage
- 81
View Lastest Price from 4-METHOXYPHENYLACETYL CHLORIDE manufacturers
- Product
- 4-Methoxyphenylacetyl chloride 4693-91-8
- Price
- US $1.00-1.50/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100000KG
- Release date
- 2024-08-06
- Product
- 4-METHOXYPHENYLACETYL CHLORIDE 4693-91-8
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-15