Tubulysin A,TubA

Product Name: Tubulysin A,TubA
CAS No.: 205304-86-5
Chemical Name: Tubulysin A,TubA
Synonyms: TubA;CS-1324;Tubulysin A;Tubulysins A;Tubulysin A,TubA;(2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-4-methyl-3-[3-methylbutanoyloxymethyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-5-(4-hydroxyphenyl)-2-methylpentanoicaci;Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(3-methyl-1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)-
CBNumber: CB92518395
Molecular Formula: C43H65N5O10S
Formula Weight: 844.07
MOL File: 205304-86-5.mol

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Tubulysin A,TubA Property

Melting point:: 106-108 °C(Solv: methanol (67-56-1); water (7732-18-5))
Boiling point:: 979.9±65.0 °C(Predicted)
Density: 1.195±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: organic solvents: soluble
form: film
pka: 4.52±0.23(Predicted)
color: colorless or white
biological source: Streptomyces sp.

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Safety

Hazard Codes: T
Risk Statements: 23/24/25-36/37/38
Safety Statements: 36/37-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: T897135
Product name: TubulysinA
Packaging: 0.25mg
Price: $385
Updated: 2021/12/16

TRC

Product number: T897135
Product name: TubulysinA
Packaging: 1mg
Price: $1405
Updated: 2021/12/16

TRC

Product number: T897135
Product name: TubulysinA
Packaging: 2.5mg
Price: $2805
Updated: 2021/12/16

TRC

Product number: T897135
Product name: TubulysinA
Packaging: 5mg
Price: $4235
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0004574
Product name: TUBULYSIN A
Purity: 95.00%
Packaging: 1MG
Price: $2684.85
Updated: 2021/12/16

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Tubulysin A,TubA Chemical Properties,Usage,Production

Uses

Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative.

Definition

ChEBI: Tubulysin A is a diester and a carboxylic acid.

Biochem/physiol Actions

Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (A-I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range.

Tubulysin A,TubA Preparation Products And Raw materials

Raw materials

Preparation Products

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Tubulysin A,TubA Suppliers

China 39 Germany 1 India 4 United States 9 Global 53

MedChemexpress LLC

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Musechem

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Alfa Chemistry

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Cckinase, Inc.

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BOC Sciences

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Eastman Chemical Company

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MedChemExpress

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Riedel-de Haen AG

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View Lastest Price from Tubulysin A,TubA manufacturers

Career Henan Chemical Co

Product: Tubulysin A,TubA 205304-86-5
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2019-12-25

205304-86-5, Tubulysin A,TubARelated Search:

2-Aminoethyl(ethyl)amine N-Ethyl-3-methylaniline N-ethyl-pyrrolidone N-(2-Hydroxyethyl)-2-pyrrolidone

TubA

Tubulysin A

Tubulysin A,TubA

Tubulysins A

CS-1324

Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(3-methyl-1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)-

(2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-4-methyl-3-[3-methylbutanoyloxymethyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-5-(4-hydroxyphenyl)-2-methylpentanoicaci

205304-86-5

C43H65N5O10S