ChemicalBook > CAS DataBase List > CP466722

CP466722

Product Name
CP466722
CAS No.
1080622-86-1
Chemical Name
CP466722
Synonyms
CS-73;CP466722;CP-466722, >98%;CP-466722;CP466722;CP466722 USP/EP/BP;CP466722 >=98% (HPLC);CP466722;CP 466722;CP-466722;2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine;1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine
CBNumber
CB92535567
Molecular Formula
C17H15N7O2
Formula Weight
349.35
MOL File
1080622-86-1.mol
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CP466722 Property

Boiling point:
642.3±65.0 °C(Predicted)
Density 
1.48
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
DMSO: soluble0.5mg/mL, clear (warmed)
pka
0.00±0.19(Predicted)
form 
powder
color 
white to beige
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1115
Product name
CP466722
Purity
≥98% (HPLC)
Packaging
5mg
Price
$212
Updated
2022/05/15
Sigma-Aldrich
Product number
SML1115
Product name
CP466722
Purity
≥98% (HPLC)
Packaging
25mg
Price
$724
Updated
2022/05/15
Cayman Chemical
Product number
25417
Product name
CP 466,722
Purity
≥98%
Packaging
1mg
Price
$41
Updated
2024/03/01
Cayman Chemical
Product number
25417
Product name
CP 466,722
Purity
≥98%
Packaging
5mg
Price
$183
Updated
2024/03/01
Cayman Chemical
Product number
25417
Product name
CP 466,722
Purity
≥98%
Packaging
10mg
Price
$322
Updated
2024/03/01
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CP466722 Chemical Properties,Usage,Production

Description

CP 466,722 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase that inhibits ionizing radiation-induced ATM autophosphorylation and phosphorylation of the ATM targets SMC1, Chk2, and p53 in HeLa cells when used at a concentration of 10 μM. It is selective for ATM over PI3K and PIKK in HFF(hTERT) and A-T(hTERT) fibroblasts, respectively. CP 466,722 decreases cell survival in response to ionizing radiation in HeLa cells. It is also cytotoxic to MCF-7 and SKBr-3 breast cancer cells (IC50s = 16.92 and 12.78 μM, respectively).

Uses

CP466722 is a competetive, reversible inhbitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase

Definition

ChEBI: 2-(6,7-dimethoxy-4-quinazolinyl)-5-(2-pyridinyl)-1,2,4-triazol-3-amine is a member of quinazolines.

target

ATM

References

[1]. guo, k., et al., development of a cell-based, high-throughput screening assay for atm kinase inhibitors. j biomol screen, 2014. 19(4): p. 538-46.
[2]. nadkarni, a., et al., atm inhibitor ku-55933 increases the tmz responsiveness of only inherently tmz sensitive gbm cells. j neurooncol, 2012. 110(3): p. 349-57.
[3]. rainey, m.d., et al., transient inhibition of atm kinase is sufficient to enhance cellular sensitivity to ionizing radiation. cancer res, 2008. 68(18): p. 7466-74.

CP466722 Preparation Products And Raw materials

Raw materials

Preparation Products

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CP466722 Suppliers

China 82 France 1 India 1 United States 19 Global 103
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
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58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
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58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
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58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
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58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
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58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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81
Creative Enzymes
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--
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Email
info@creative-enzymes.com
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United States
ProdList
6057
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58
MedChemExpress
Tel
--
Fax
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Email
sales@medchemexpress.com
Country
United States
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6398
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58
Axon Medchem LLC
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info@axonmedchem.com
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United States
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763
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Riedel-de Haen AG
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--
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United States
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6773
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Matrix Scientific
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--
Fax
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sales@matrixscientific.com
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United States
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6632
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80
NE Scientific
Tel
--
Fax
--
Country
United States
ProdList
5030
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55
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View Lastest Price from CP466722 manufacturers

Career Henan Chemical Co
Product
CP466722;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine 1080622-86-1
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
95%~99%
Supply Ability
per week:100kg
Release date
2019-09-05

1080622-86-1, CP466722Related Search:

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  • CP466722
  • 1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine
  • CP466722;CP 466722;CP-466722
  • CS-73
  • CP-466722, >98%
  • 2-(6,7-dimethoxyquinazolin-4-yl)-5-(pyridin-2-yl)-2H-1,2,4-triazol-3-amine
  • 1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine CP 466722
  • 2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine
  • CP-466722;CP466722
  • 1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine
  • 1H-1,2,4-Triazol-5-amine, 1-(6,7-dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-
  • CP466722 >=98% (HPLC)
  • CP466722 USP/EP/BP
  • 1080622-86-1
  • C17H15N7O2
  • Inhibitors