OMecaMtiv Mecarbil
Description In vitro In vivo- Product Name
- OMecaMtiv Mecarbil
- CAS No.
- 873697-71-3
- Chemical Name
- OMecaMtiv Mecarbil
- Synonyms
- CS-827;CK1827452;CK-1827452;CK 1827452O;CK1827452, >98%;mecamtiv mecarbil;OMecaMtiv Mecarbil;Omecamtiv mecarbil?, >98%;OMecaMtiv Mecarbil USP/EP/BP;CK-1827452 (OMecaMtiv Mecarbil)
- CBNumber
- CB92561487
- Molecular Formula
- C20H24FN5O3
- Formula Weight
- 401.43
- MOL File
- 873697-71-3.mol
OMecaMtiv Mecarbil Property
- Melting point:
- 180℃
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- 40.25mg/L at 25℃
- LogP
- -0.531
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H370Causes damage to organs
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P307+P311IF exposed: call a POISON CENTER or doctor/physician.
P314Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 21074
- Product name
- CK-1827452
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 21074
- Product name
- CK-1827452
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $169
- Updated
- 2024/03/01
- Product number
- 21074
- Product name
- CK-1827452
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $301
- Updated
- 2024/03/01
- Product number
- 21074
- Product name
- CK-1827452
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $661
- Updated
- 2024/03/01
- Product number
- C544000
- Product name
- CK1827452
- Packaging
- 50mg
- Price
- $820
- Updated
- 2021/12/16
OMecaMtiv Mecarbil Chemical Properties,Usage,Production
Description
Omecamtiv mecarbil (CK-1827452) is a specific cardiac myosin activator and a clinical drug for left ventricular systolic heart failure. Phase 2.
In vitro
In vitro, Omecamtiv mecarbil selectively activates cardiac myosin by increasing the myosin ATPase rate. In isolated cardiac myocytes, Omecamtiv mecarbil results in increase of myocyte contractility and overcomes of the myosin inhibitor BDM without increasing the calcium transient or inhibiting the PDE pathway. [
In vivo
Omecamtiv mecarbil significantly increases fractional shortening starting at 0.4 mM plasma concentrations in SD rats, sham animals and in rats with heart failure. In conscious dogs with myocardial infarction (MI-sHF), Omecamtiv mecarbil leads to a significant increase in wall thickening (25%), stroke volume (44%), cardiac output (22%) and left ventricular (LV) systolic ejection time (26%). In addition, Omecamtiv mecarbil also results in the decreases of some hemodynamic parameters including heart rate, mean left atrial pressure, and LV end-diastolic pressure. In conscious dogs with left ventricular hypertrophy (LVH-sHF), Omecamtiv mecarbil leads to similar and not statistically different effects on hemodynamic parameters.
Uses
CK 1827452 is a promising new drug in systolic heart failure. It accelerates the transition of myosin into the force-generating state without affecting cardiac myocyte calcium homeostasis. CK 1827452 increases cardiac function by increasing the duration of ejection without changing the rates of contraction.
Definition
ChEBI: Omecamtiv mecarbil is a member of ureas.
Biological Activity
omecamtiv mecarbil (ck-1827452) is the first potent cardiac myosin activator that can specifically activate the cardiac myosin s1 domain but not other muscle myosins. in
target
ATPase
References
1. malik fi1, hartman jj, elias ka, morgan bp, rodriguez h, brejc k, anderson rl, sueoka sh, lee kh, finer jt, sakowicz r, baliga r, cox dr, garard m,godinez g, kawas r, kraynack e, lenzi d, lu pp, muci a, niu c, qian x, pierce dw, pokrovskii m, suehiro i, sylvester s, tochimoto t, valdez c, wang w,katori t, kass da, shen yt, vatner sf, morgans dj. cardiac myosin activation: a potential therapeutic approach for systolic heart failure. science. 2011 mar 18;331(6023):1439-43.
OMecaMtiv Mecarbil Preparation Products And Raw materials
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View Lastest Price from OMecaMtiv Mecarbil manufacturers
- Product
- Omecamtiv Mecarbil 873697-71-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5000kg
- Release date
- 2020-08-20
- Product
- OMecaMtiv Mecarbil 873697-71-3
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 95%~99%
- Supply Ability
- per week:100kg
- Release date
- 2019-09-05