ChemicalBook > CAS DataBase List > NSC-348884

NSC-348884

Product Name
NSC-348884
CAS No.
81624-55-7
Chemical Name
NSC-348884
Synonyms
CS-2168;NSC-348884;NSC 348884/NSC348884;NSC348884;NSC-348884;NSC 348884;N,N,N',N'-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]ethane-1,2-diamine;N1,N1,N2,N2-Tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-1,2-ethanediamine;1,2-Ethanediamine, N1,N1,N2,N2-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-;1,2-EthanediaMine, N,N,N',N'-tetrakis[(5-Methyl-1H-benziMidazol-2-yl)Methyl]- (9CI);lymphoma,cancer,inhibit,SKOV3,MOSEC/Luc cell,NSC-348884,NSC 348884,LNCaP,doxorubicin,NSC348884,Inhibitor,ES2,small molecular,p53,Apoptosis
CBNumber
CB92582798
Molecular Formula
C38H40N10
Formula Weight
636.79
MOL File
81624-55-7.mol
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NSC-348884 Property

Boiling point:
1001.7±65.0 °C(Predicted)
Density 
1.347
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
≥63.7 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form 
solid
pka
11.61±0.10(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16716
Product name
NSC 348884
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
16716
Product name
NSC 348884
Purity
≥98%
Packaging
5mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
16716
Product name
NSC 348884
Purity
≥98%
Packaging
10mg
Price
$214
Updated
2024/03/01
Cayman Chemical
Product number
16716
Product name
NSC 348884
Purity
≥98%
Packaging
25mg
Price
$479
Updated
2024/03/01
TRC
Product number
N900560
Product name
NSC348884
Packaging
250mg
Price
$250
Updated
2021/12/16
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NSC-348884 Chemical Properties,Usage,Production

Uses

NSC348884 is a biochemical which inhibitss NPM oligomer formation, upregulates p53 and induces apoptosis.

Biological Activity

nsc348884 is a nucleophosmin inhibitor.nucleophosmin is identified as a multifunctional nucleolar phosphoprotein, which is dysregulated in human malignancies resulting in anti-apoptosis and differentiation inhibition.

in vitro

nsc348884, which was identified as a putative nucleophosmin small molecular inhibitor, was found to be able to disrupt a hydrophobic pocket that was required for oligomerization, and nsc348884 could also inhibit the cell proliferation in distinct cancer cell lines and disrupt nucleophosmin oligomer formation. moreover, the treatment of several cancer cell types with nsc348884 could dose-dependently upregulate p53 and also induce apoptosis that correlated with h2ax phosphorylation, poly(adp-ribose) polymerase cleavage as well as annexin v. furthermore, nsc348884 could also synergize doxorubicin cytotoxicity on the viability of cancer cells [1].

in vivo

previous study showed that the in-vivo intravasation and invasion could be significantly inhibited after the injection of nsc348884 into the tumor-bearing mice. in addition, there was no significant difference in overall cell death that was observed by histology in the treated tumors with the 4-hour brief treatments, indicating that the inhibition seen was specific to migration [2].

IC 50

1.7-4.0 μm for tested cancer cell lines

References

[1] qi w,shakalya k,stejskal a,goldman a,beeck s,cooke l,mahadevan d. nsc348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells. oncogene.2008 jul 10;27(30):4210-20.
[2] patsialou a,wang y,lin j,whitney k,goswami s,kenny pa,condeelis js. selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients. breast cancer res.2012 oct 31;14(5):r139.

NSC-348884 Preparation Products And Raw materials

Raw materials

Preparation Products

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NSC-348884 Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
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55
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
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China
ProdList
4727
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58
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
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58
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
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55
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
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60
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
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+86-21-52996696
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China
ProdList
4456
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55
D&C Chemicals
Tel
+86-21-58447131
Fax
+86-21-61642470
Email
1724405207@qq.com
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China
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472
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55
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
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55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
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58
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View Lastest Price from NSC-348884 manufacturers

Career Henan Chemical Co
Product
NSC-348884 81624-55-7
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-25

81624-55-7, NSC-348884Related Search:


  • NSC-348884
  • N1,N1,N2,N2-Tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-1,2-ethanediamine
  • 1,2-EthanediaMine, N,N,N',N'-tetrakis[(5-Methyl-1H-benziMidazol-2-yl)Methyl]- (9CI)
  • CS-2168
  • NSC348884;NSC-348884;NSC 348884
  • 1,2-Ethanediamine, N1,N1,N2,N2-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-
  • lymphoma,cancer,inhibit,SKOV3,MOSEC/Luc cell,NSC-348884,NSC 348884,LNCaP,doxorubicin,NSC348884,Inhibitor,ES2,small molecular,p53,Apoptosis
  • NSC 348884/NSC348884
  • N,N,N',N'-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]ethane-1,2-diamine
  • 81624-55-7
  • C38H40N10