ChemicalBook > CAS DataBase List > CAY10415

CAY10415

Product Name
CAY10415
CAS No.
146062-49-9
Chemical Name
CAY10415
Synonyms
0160;CS-1615;CAY10415;MSDC-0160;MSDC-​Mitoglitazone;MSDC-0160(CAY10415);CAY10415 MSDC-0160;CAY10415 Exclusive;CAY10415 (Mitoglitazone)
CBNumber
CB92590409
Molecular Formula
C19H18N2O4S
Formula Weight
370.42
MOL File
146062-49-9.mol
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CAY10415 Property

Boiling point:
623.8±55.0 °C(Predicted)
Density 
1.315±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
≥37 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form 
A crystalline solid
pka
6.32±0.50(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1884
Product name
Mitoglitazone
Purity
≥98% (HPLC)
Packaging
5MG
Price
$102
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1884
Product name
Mitoglitazone
Purity
≥98% (HPLC)
Packaging
25MG
Price
$330
Updated
2023/06/20
Cayman Chemical
Product number
71748
Product name
CAY10415
Purity
≥98%
Packaging
1mg
Price
$39
Updated
2024/03/01
Cayman Chemical
Product number
71748
Product name
CAY10415
Purity
≥98%
Packaging
5mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
71748
Product name
CAY10415
Purity
≥98%
Packaging
10mg
Price
$189
Updated
2024/03/01
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CAY10415 Chemical Properties,Usage,Production

Uses

CAY10415 is used to study blood glucose levels and rates of insulin-stimulated lipogenesis.

Definition

ChEBI: 5-[[4-[2-(5-ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]thiazolidine-2,4-dione is an aromatic ether.

Biological Activity

msdc-0160 is a prototype mtot-modulating insulin sensitizer [1].msdc-0160 is a thiazolidinedione insulin sensitizer without the peroxisome proliferator–activated receptor-γ (ppar-γ)-dependent side effects. co-incubation of islets with msdc-0160 and igf-1 reduces the resistance of insulin-signaling pathway and preserves insulin content. msdc-0160 at 50μm alone also prevents the loss of insulin content significantly. besides that, treatment of msdc-0160 increases the phosphorylation of ampk and reduces mtor phosphorylation. moreover, msdc-0160 is also found to display pro-survival effects in human islets via reducing the level of cleaved caspase-3 and increasing the expression of apoptosis-related genes such as bcl2. in addition, msdc-0160 exerts prevention of nuclear translocation with β-catenin localized on the cell membrane or cytoplasm in human β-cells [1].

References

[1] rohatgi n, aly h, marshall c a, et al. novel insulin sensitizer modulates nutrient sensing pathways and maintains β-cell phenotype in human islets. plos one, 2013, 8(5): e62012.

CAY10415 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10415 Suppliers

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146062-49-9, CAY10415Related Search:

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  • CAY10415
  • MSDC-0160
  • CAY10415;CAY-10415;CAY 10415;MSDC 0160;MSDC0160
  • CS-1615
  • MITOGLITAZONE;CAY10415;MSDC 0160
  • 2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-
  • CAY10415 (Mitoglitazone)
  • Mitoglitazone
  • 5-[[4-[2-(5-ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-Thiazolidinedione
  • 5-(4-(2-(5-Ethylpyridin-2-yl)-2-oxoethoxy)-benzyl)thiazolidine-2,4-dione
  • MSDC-0160(CAY10415)
  • CAY10415 MSDC-0160
  • 5-[[4-[2-(5-ethylpyridin-2-yl)-2-oxoethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
  • MSDC-0160 (Mitoglitazone
  • CAY10415 Exclusive
  • 0160
  • MSDC-&#8203
  • Mitoglitazone (MSDC-0160)
  • 146062-49-9
  • Inhibitors