N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester
- Product Name
- N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester
- CAS No.
- 1334513-02-8
- Chemical Name
- N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester
- Synonyms
- SF-1.2;ATP-FTP-phoph;Sofosbuvir imp-75;Sofosbuvir-003-SS;SofosBuvir Impurity 15;Sofosbuvir InterMediates;Sofibuvir intermediate 1;Sofosbuvir Intermediate 5;Sofosbuvir side chain N-1;Sofosbuvir InterMediates4
- CBNumber
- CB92604353
- Molecular Formula
- C18H17F5NO5P
- Formula Weight
- 453.3
- MOL File
- 1334513-02-8.mol
N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester Property
- Melting point:
- 133-135°C
- Boiling point:
- 442.6±55.0 °C(Predicted)
- Density
- 1.405
- vapor pressure
- 0Pa at 25℃
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- -3.81±0.70(Predicted)
- form
- Solid
- color
- White
- InChI
- InChI=1/C18H17F5NO5P/c1-9(2)27-18(25)10(3)24-30(26,28-11-7-5-4-6-8-11)29-17-15(22)13(20)12(19)14(21)16(17)23/h4-10H,1-3H3,(H,24,26)/t10-,30?/s3
- InChIKey
- MIILDBHEJQLACD-YPKMSJFYNA-N
- SMILES
- C(OC(C)C)(=O)[C@H](C)NP(OC1=C(F)C(F)=C(F)C(F)=C1F)(OC1=CC=CC=C1)=O |&1:6,r|
- LogP
- 4.1 at 30℃ and pH7.37
Safety
- HS Code
- 2931599090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- D228775
- Product name
- 2’-Defluro-2’-hydroxy2’-epi-Sofosbuvir
- Packaging
- 5mg
- Price
- $395
- Updated
- 2021/12/16
- Product number
- D228775
- Product name
- 2’-Defluro-2’-hydroxy2’-epi-Sofosbuvir
- Packaging
- 25mg
- Price
- $1425
- Updated
- 2021/12/16
- Product number
- 48139
- Product name
- N-[(S)-(2,3,4,5,6-Pentafluorophenoxy)phenoxyphosphinyl]-L-alanine1-MethylethylEster
- Packaging
- 1g
- Price
- $675
- Updated
- 2021/12/16
- Product number
- 3895AH
- Product name
- N-[(S)-(2,3,4,5,6-Pentafluorophenoxy)phenoxyphosphinyl]-L-alanine1-methylethylester
- Packaging
- 100g
- Price
- $810
- Updated
- 2021/12/16
- Product number
- AAA0017824
- Product name
- PROPAN-2-YL (2S)-2-([(S)-PENTAFLUOROPHENOXY(PHENOXY)PHOSPHORYL]AMINO)PROPANOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $457.49
- Updated
- 2021/12/16
N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester Chemical Properties,Usage,Production
Uses
N-[(S)-(2,3,4,5,6-Pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester is a reactant in the synthesis of phosphoramidate imidazo[2,1-f][1,2,4]triazine-4-amine adenosine prodrugs that can increase anti-HCV activity.
Synthesis
771-61-9
770-12-7
39613-92-8
1334513-02-8
Phenyl dichlorophosphate (64.2 mL, 430 mmol) and dichloromethane (DCM, 1200 mL) were added to a reaction vial containing (S)-isopropyl 2-aminopropionic acid hydrochloride (72.0 g, 430 mmol). The reaction mixture was cooled to -70 to -78°C using a dry ice-acetone bath, followed by slow dropwise addition of triethylamine (120 mL, 859 mmol) over 30 min. The temperature was maintained at -70 to -78°C with stirring for 30 minutes, then the reaction mixture was allowed to slowly warm to room temperature and stirring was continued for 1 hour. Subsequently, the reaction mixture was cooled to 0-5°C in an ice bath and 100 mL of DCM solution containing 2,3,4,5,6-pentafluorophenol (79 g, 430 mmol) and triethylamine (59.9 mL, 430 mmol) was added slowly over a dropwise period of 30 minutes. The resulting mixture was stirred at -70 to -78°C for 30 minutes, then warmed to room temperature and stirred for 2 hours. Upon completion of the reaction, the solid was collected by filtration and the filter cake was washed with 200 mL of ethyl acetate. The filtrate and washings were combined and concentrated to a semi-solid state by vacuum distillation. This semi-solid was dissolved in 500 mL of ethyl acetate and washed sequentially with water and brine. The aqueous phase was back-extracted with 50 mL of ethyl acetate. The organic layers were combined, dried with anhydrous MgSO4 and concentrated to give 210 g of crude product in 100% yield.NMR analysis showed the crude product to be a 1:1 mixture of diastereoisomers. To obtain the target SS diastereoisomers, kinetic splitting was performed: the crude product was suspended in 500 mL of 20% ethyl acetate/hexane, and 20 mL of 20% ethyl acetate/hexane solution containing 5 g of pentafluorophenol, 10 mL of triethylamine, and 100 mg of dimethylaminopyridine was added. The reaction mixture was heated to 45-50°C kept for 30 minutes and then stirred overnight. The white solid was collected by filtration, washed with 200 mL of 20% ethyl acetate/hexane and 100 mL of hexane, and dried under vacuum at 40°C to give 98 g of white solid, which was shown to be predominantly SS diastereoisomer by NMR analysis. The filtrate and washings were combined and concentrated to give a semi-solid, mainly another diastereoisomer and impurities. This residue was dissolved in 150 mL of ethyl acetate and washed sequentially with 50 mL of 1N HCl, water and 5% K2CO3 solution. The organic layer was dried and concentrated, and the white residue was suspended in 100 mL of 20% ethyl acetate/hexane, the solid was collected by filtration, washed with 20% ethyl acetate/hexane and hexanes, and dried to give 22 g of white solid, which was shown to be predominantly the SS diastereoisomer by NMR analysis. The total product weight after splitting was 120 g in 61.6% yield.
References
[1] Patent: WO2017/223421, 2017, A1. Location in patent: Page/Page column 68; 69
[2] Patent: WO2016/30335, 2016, A1. Location in patent: Page/Page column 51
[3] Patent: CN107405356, 2017, A. Location in patent: Paragraph 0209; 0210; 0213; 0214; 0215; 0216; 0217
[4] Journal of Organic Chemistry, 2011, vol. 76, # 20, p. 8311 - 8319
[5] Patent: WO2016/99982, 2016, A2. Location in patent: Page/Page column 55
N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester Preparation Products And Raw materials
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View Lastest Price from N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester manufacturers
- Product
- N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester 1334513-02-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester 1334513-02-8
- Price
- US $161.00/g
- Min. Order
- 500g
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2021-06-03
- Product
- n-[(s)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-l-alanine 1-methylethyl ester 1334513-02-8
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 200tons
- Release date
- 2024-04-08