EMD638683

Product Name: EMD638683
CAS No.: 1181770-72-8
Chemical Name: EMD638683
Synonyms: ]-2-ethyL;EMD638683;N'-[2-(3,5-DifL;)-2-hydroxyacetyL;-4-hydroxy-3-methyL;EMD 638683;EMD-638683;EMD638683, 10 mM in DMSO;N'-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-ethyl-4-hydroxy-3-methylbenzohydrazide;N'-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-ethyl-4-hydroxy-3-methylbenzohydrazide;2-(3,5-difluorophenyl)-N'-(2-ethyl-4-hydroxy-3-met hylbenzoyl)-2-hydroxyacetohydrazide
CBNumber: CB92627800
Molecular Formula: C18H18F2N2O4
Formula Weight: 364.34
MOL File: 1181770-72-8.mol

More

Less

EMD638683 Property

Boiling point:: 657.6±55.0 °C(Predicted)
Density: 1.363±0.06 g/cm3(Predicted)
storage temp.: -10 to -25°C
solubility: insoluble in H2O; ≥18.2 mg/mL in DMSO; ≥45.8 mg/mL in EtOH with gentle warming
form: solid
pka: 8.68±0.25(Predicted)
color: Off-white to light brown

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

More

Less

N-Bromosuccinimide Price

ApexBio Technology

Product number: A3389
Product name: EMD638683
Packaging: 5mg
Price: $261
Updated: 2021/12/16

ChemScene

Product number: CS-1344
Product name: EMD638683
Purity: 99.74%
Packaging: 5mg
Price: $312
Updated: 2021/12/16

ApexBio Technology

Product number: A3389
Product name: EMD638683
Packaging: 10mg
Price: $336
Updated: 2021/12/16

ChemScene

Product number: CS-1344
Product name: EMD638683
Purity: 99.74%
Packaging: 10mg
Price: $402
Updated: 2021/12/16

ChemScene

Product number: CS-1344
Product name: EMD638683
Purity: 99.74%
Packaging: 50mg
Price: $1086
Updated: 2021/12/16

More

Less

EMD638683 Chemical Properties,Usage,Production

Biological Activity

EMD638683 is an orally active and highly selective serum/glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC50 = 3 μM against HeLa cellular NDRG1 phosphorylation) th at significantly decreased blood pressure in fructose-treated mice but not in control saline-treated or in SGK1-knockout animals (4460 ppm in chow, ~600 mg/kg/day). EMD638683 promotes radiation-induced suicidal death of CaCo-2 colon tumor cells in vitro (50 μM) and decreases the number of colonic tumors following chemical carcinogenesis in vivo (4460 ppm in chow).

target

SGK1

EMD638683 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

EMD638683 Suppliers

China 69 United States 10 Global 79

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4573
Advantage: 55

ShangHai Angti Biotechnology Co., Ltd.

Tel: 13764913901
Fax: -
Email: info@angtibio.com
Country: China
ProdList: 5028
Advantage: 55

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 17687
Advantage: 55

ATK CHEMICAL COMPANY LIMITED

Tel: 021-51619050 13301662590
Fax: +86-21-51619052
Email: mandy@atkchemical.com
Country: China
ProdList: 10197
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

1181770-72-8, EMD638683Related Search:

4-Hydroxybenzoic acid 4-HYDROXYPHENOXYACETIC ACID Ethylparaben 4'-Hydroxyacetophenone 4-Hydroxyphenylacetic acid

EMD638683

3,5-Difluoro-alpha-hydroxybenzeneacetic acid 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide

EMD 638683;EMD-638683

)-2-hydroxyacetyL

N'-[2-(3,5-DifL

N'-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-ethyl-4-hydroxy-3-methylbenzohydrazide

Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide

]-2-ethyL

-4-hydroxy-3-methyL

2-(3,5-difluorophenyl)-N'-(2-ethyl-4-hydroxy-3-met hylbenzoyl)-2-hydroxyacetohydrazide

N'-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-ethyl-4-hydroxy-3-methylbenzohydrazide

EMD638683, 10 mM in DMSO

1181770-72-8