ChemicalBook > CAS DataBase List > EMD638683

EMD638683

Product Name
EMD638683
CAS No.
1181770-72-8
Chemical Name
EMD638683
Synonyms
]-2-ethyL;EMD638683;N'-[2-(3,5-DifL;)-2-hydroxyacetyL;-4-hydroxy-3-methyL;EMD 638683;EMD-638683;EMD638683, 10 mM in DMSO;N'-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-ethyl-4-hydroxy-3-methylbenzohydrazide;2-(3,5-difluorophenyl)-N'-(2-ethyl-4-hydroxy-3-met hylbenzoyl)-2-hydroxyacetohydrazide;Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide
CBNumber
CB92627800
Molecular Formula
C18H18F2N2O4
Formula Weight
364.34
MOL File
1181770-72-8.mol
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EMD638683 Property

Boiling point:
657.6±55.0 °C(Predicted)
Density 
1.363±0.06 g/cm3(Predicted)
storage temp. 
-10 to -25°C
solubility 
insoluble in H2O; ≥18.2 mg/mL in DMSO; ≥45.8 mg/mL in EtOH with gentle warming
form 
solid
pka
8.68±0.25(Predicted)
color 
Off-white to light brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3410
Product name
EMD638683
Purity
≥98% (HPLC)
Packaging
10 mg
Price
$272.65
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3410
Product name
EMD638683
Purity
≥98% (HPLC)
Packaging
50 mg
Price
$1150
Updated
2025/07/31
ChemScene
Product number
CS-1344
Product name
EMD638683
Purity
99.74%
Packaging
100mg
Price
$1800
Updated
2021/12/16
ChemScene
Product number
CS-1344
Product name
EMD638683
Purity
99.74%
Packaging
5mg
Price
$312
Updated
2021/12/16
ApexBio Technology
Product number
A3389
Product name
EMD638683
Packaging
10mg
Price
$336
Updated
2021/12/16
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EMD638683 Chemical Properties,Usage,Production

Uses

EMD638683 is a highly selective SGK1 inhibitor, with an IC50 value of 3 μM.

Biological Activity

EMD638683 is an orally active and highly selective serum/glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC50 = 3 μM against HeLa cellular NDRG1 phosphorylation) th at significantly decreased blood pressure in fructose-treated mice but not in control saline-treated or in SGK1-knockout animals (4460 ppm in chow, ~600 mg/kg/day). EMD638683 promotes radiation-induced suicidal death of CaCo-2 colon tumor cells in vitro (50 μM) and decreases the number of colonic tumors following chemical carcinogenesis in vivo (4460 ppm in chow).

in vivo

The colon is significantly longer and the colon weight significantly lower in EMD638683-treated mice than in placebo-treated mice, a finding pointing to an influence of EMD638683 on tumor growth following chemical carcinogenesis. In addition, the stomach weight is significantly lower in the EMD treated group. Most importantly, the number of developing tumors following carcinogenic treatment is significantly blunted by EMD638683 treatment[2]. EMD638683 (20 mg/kg, intragastrically) prevents progression of monocrotaline (MCT)-induced pulmonary vascular remodeling in rats. Hemodynamic characteristics show that EMD638683 treatment attenuates right ventricular systolic pressure (RVSP) (15.8±2.5 vs. 28.2±3.1 mmHg; P<0.05; n=6) and right ventricular hypertrophy index (RVHI) (0.27±0.02 vs. 0.41±0.06;P<0.05; n=6) compare to vehicle-dosed controls[3].

target

SGK1

IC 50

SGK1

References

[1] Ackermann TF, et al. EMD638683, a novel SGK inhibitor with antihypertensive potency. Cell Physiol Biochem. 2011;28(1):137-46. DOI:10.1159/000331722
[2] Towhid ST, et al. Inhibition of colonic tumor growth by the selective SGK inhibitor EMD638683. Cell Physiol Biochem. 2013;32(4):838-48. DOI:10.1159/000354486
[3] Xi X, et al. Serum-glucocorticoid regulated kinase 1 regulates macrophage recruitment and activation contributing to monocrotaline-induced pulmonary arterial hypertension. Cardiovasc Toxicol. 2014 Dec;14(4):368-78. DOI:10.1007/s12012-014-9260-4
[4] Zhou H, et al. Inhibition of serum- and glucocorticoid-inducible kinase 1 enhances TLR-mediated inflammation and promotes endotoxin-driven organ failure. FASEB J. 2015 Sep;29(9):3737-49. DOI:10.1096/fj.15-270462

EMD638683 Preparation Products And Raw materials

Raw materials

Preparation Products

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EMD638683 Suppliers

China 85 United States 10 Global 95
AdooQ BioScience, LLC
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+1 (866) 930-6790
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Musechem
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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InvivoChem
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+1-708-310-1919 +1-13798911105
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708-557-7486
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Aladdin Scientific
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TargetMol Chemicals Inc.
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support@targetmol.com
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ApexBio Technology
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Cayman Chemical Company
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Creative Enzymes
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1181770-72-8, EMD638683Related Search:

4-Hydroxybenzoic acid 4-HYDROXYPHENOXYACETIC ACID Ethylparaben 4'-Hydroxyacetophenone 4-Hydroxyphenylacetic acid

  • EMD638683
  • 3,5-Difluoro-alpha-hydroxybenzeneacetic acid 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide
  • EMD 638683;EMD-638683
  • )-2-hydroxyacetyL
  • N'-[2-(3,5-DifL
  • N'-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-ethyl-4-hydroxy-3-methylbenzohydrazide
  • Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide
  • ]-2-ethyL
  • -4-hydroxy-3-methyL
  • 2-(3,5-difluorophenyl)-N'-(2-ethyl-4-hydroxy-3-met hylbenzoyl)-2-hydroxyacetohydrazide
  • EMD638683, 10 mM in DMSO
  • 1181770-72-8