1,11b-Dihydro-11b-hydroxyMedicarpin

Product Name: 1,11b-Dihydro-11b-hydroxyMedicarpin
CAS No.: 210537-04-5
Chemical Name: 1,11b-Dihydro-11b-hydroxyMedicarpin
Synonyms: 1,11B-DIHYDRO-11B-HYDROXYMEDICAR;1,11b-Dihydro-11b-hydroxyMedicarpin;11b-Hydroxy-11b1-dihydromedicarpin/111b-Dihydro-11b-hydroxymedicarpin;(6aR,11aR,11bS)-1,2,6,6a,11a,11b-Hexahydro-11b-hydroxy-9-methoxy-3H-benzofuro[3,2-c][1]benzopyran-3-one;3H-Benzofuro[3,2-c][1]benzopyran-3-one, 1,2,6,6a,11a,11b-hexahydro-11b-hydroxy-9-methoxy-, (6aR,11aR,11bS)-
CBNumber: CB92630046
Molecular Formula: C16H16O5
Formula Weight: 288.3
MOL File: 210537-04-5.mol

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1,11b-Dihydro-11b-hydroxyMedicarpin Property

Boiling point:: 490.0±45.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 13.53±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Arctom

Product number: CFN96002
Product name: 1,11b-Dihydro-11b-hydroxymedicarpin
Purity: ≥98%
Packaging: 5mg
Price: $553
Updated: 2021/12/16

Crysdot

Product number: CD32002004
Product name: 1,11b-Dihydro-11b-hydroxymedicarpin
Purity: 95+%
Packaging: 5mg
Price: $860
Updated: 2021/12/16

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1,11b-Dihydro-11b-hydroxyMedicarpin Chemical Properties,Usage,Production

Uses

1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative[1]. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways[2]. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice[3].

References

[1] Alejandro F.Barrero, et al. Pterocarpans from Ononis viscosa subsp. breviflora. Phytochemistry. 1998 May, 48 (1): 187-190.
[2] Manisha Dixit, et al. Medicarpin, a Natural Pterocarpan, Heals Cortical Bone Defect by Activation of Notch and Wnt Canonical Signaling Pathways. PLoS One. 2015 Dec 11;10(12):e0144541. DOI:10.1371/journal.pone.0144541
[3] Mohd Nizam Mansoori, et al. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Int Immunopharmacol. 2020 Feb 22;82:106299. DOI:10.1016/j.intimp.2020.106299

1,11b-Dihydro-11b-hydroxyMedicarpin Preparation Products And Raw materials

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