ChemicalBook > CAS DataBase List > Doxofylline

Doxofylline

Product Name
Doxofylline
CAS No.
69975-86-6
Chemical Name
Doxofylline
Synonyms
DOXOPHYLLINE;ventax;abc12/3;ansimar;Ansirnar;MAXIVENT;ABC 1213;DOXOFYLLINE;Doxofyliine;Doxof3rlline
CBNumber
CB9265231
Molecular Formula
C11H14N4O4
Formula Weight
266.25
MOL File
69975-86-6.mol
More
Less

Doxofylline Property

Melting point:
144-146°C
Boiling point:
409.46°C (rough estimate)
Density 
1.2896 (rough estimate)
refractive index 
1.6000 (estimate)
RTECS 
XH5135000
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
0.42±0.70(Predicted)
color 
White to Off-White
Water Solubility 
Soluble
Merck 
14,3438
InChI
InChI=1S/C11H14N4O4/c1-13-9-8(10(16)14(2)11(13)17)15(6-12-9)5-7-18-3-4-19-7/h6-7H,3-5H2,1-2H3
InChIKey
HWXIGFIVGWUZAO-UHFFFAOYSA-N
SMILES
N1(CC2OCCO2)C2=C(N(C)C(=O)N(C)C2=O)N=C1
CAS DataBase Reference
69975-86-6(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37
HS Code 
29399990
Toxicity
LD50 in mice (mg/kg): 841 orally; 215.6 i.v.; in rats: 1022.4 orally, 445 i.p. (Franzone)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
D4302
Product name
Doxofylline
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$36
Updated
2024/03/01
TCI Chemical
Product number
D4302
Product name
Doxofylline
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$152
Updated
2024/03/01
Alfa Aesar
Product number
J60575
Product name
Doxofylline
Packaging
5g
Price
$129.65
Updated
2024/03/01
Cayman Chemical
Product number
18746
Product name
Doxofylline
Purity
≥98%
Packaging
1g
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
18746
Product name
Doxofylline
Purity
≥98%
Packaging
5g
Price
$139
Updated
2024/03/01
More
Less

Doxofylline Chemical Properties,Usage,Production

Description

Doxofylline, a xanthine bronchodilator related to theophylline, is useful in the treatment of asthma and similar bronchospastic disorders. It has minimal activity on intestinal smooth muscle and the cardiovascular system, and is reportedly devoid of the behavioral effects of theophylline.

Description

Doxofylline is a methylxanthine bronchodilator that has been examined in clinical trials involving patients with either bronchial asthma or chronic obstructive pulmonary disease. Its mechanism of action is related to its ability to inhibit phosphodiesterase activity and, thus, increase cAMP. Compared to other xanthine derivatives, which have direct arrhythmogenic effects, doxofylline demonstrates decreased affinity towards adenosine A1 and A2 receptors, does not interfere with calcium influx into cells, and does not antagonize the action of calcium-channel blockers.

Originator

ABC S.p.A. (Italy)

Uses

Doxofylline is a xanthine molecule that appears to be both bronchodilator and anti-inflammatory with an improved therapeutic window over conventional xanthines such as Theophylline and the evidence supporting the effects of Doxofylline in the treatment of lung diseases.

Uses

H1 antihistamine

Uses

Doxofylline is a xanthine molecule that appears to be both bronchodilator and anti-inflammatory with an improved therapeutic window over conventional xanthines such as Theophylline and the evidence su pporting the effects of Doxofylline in the treatment of lung diseases.

Definition

ChEBI: Doxofylline is an oxopurine that is a derivative of xanthine, methylated at N-1 and N-3 and carrying a 1,3-dioxolan-2-ylmethyl group at N-7, used in the treatment of asthma. It has a role as a bronchodilator agent, an antitussive and an anti-asthmatic drug. It is functionally related to a 7H-xanthine.

brand name

Maxivent (Roberts Pharmaceutical);ANSIMAR.

Doxofylline Preparation Products And Raw materials

Raw materials

p-Toluenesulfonic acid Theophylline 3-Chloro-1,2-propanediol

Preparation Products

More
Less

Doxofylline Suppliers

Americas 1 Brazil 2 Canada 4 China 296 Europe 4 Germany 3 India 85 Japan 1 Switzerland 1 United Arab Emirates 1 United Kingdom 13 United States 27 Global 438
Liaoning Yaolian Pharmaceutical Co., Ltd.
Tel
024-45567608
Email
369624997@qq.com
Country
China
ProdList
4
Advantage
58
Kaifeng Mingren Pharmaceutical Co.,LTD
Tel
0371-65741762
Fax
QQ：2860768577
Email
sales@hasunny.com
Country
China
ProdList
2380
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6011
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9551
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
Hangzhou Luckysage Sciene and Technology Co.,Ltd
Tel
0571-0571-88199336 13355710209
Fax
0571-88190523
Email
sales@luckysagechem.com
Country
China
ProdList
56
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8849
Advantage
52
Shandong Xiya Chemical Co., Ltd
Tel
13355009207 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18739
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14443
Advantage
57
ZhengZhou HuaWen Chemical Co.Ltd
Tel
0370-2785118 15343847665
Fax
QQ：3470079902
Email
huawenchem@163.com
Country
China
ProdList
3206
Advantage
55
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4647
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4941
Advantage
60
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1494
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9901
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22519
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25015
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9552
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
Zouping Mingxing Chemical Co.,Ltd.
Tel
86-13605431940 13605431940
Fax
0086-0543-2240079
Email
zpmxchemical@126.com
Country
China
ProdList
2002
Advantage
62
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Beijing Universal Century Technology Co., Ltd.
Tel
400-8706899
Fax
400-8706899
Email
hysj_bj.com
Country
China
ProdList
3585
Advantage
55
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488 18007166089
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
2024
Advantage
58
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9986
Advantage
55
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17982
Advantage
56
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13358
Advantage
58
Shanghai CanSpecsci Instrument Co., Ltd.
Tel
400-6087598 15021221957
Fax
4006087598-8012
Email
order@canspecsci.com
Country
China
ProdList
2071
Advantage
56
Shouguang Jiasheng Chemical Co., Ltd.
Tel
0536-7971999 18232719690
Fax
0536-7971999
Email
sgjiasheng@hotmail.com
Country
China
ProdList
399
Advantage
58
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4951
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10287
Advantage
55
Shanghai QianJin Chemical Technology Co., Ltd
Tel
021-20900665 17321230821
Fax
021-20900665
Email
2986274987@qq.com
Country
China
ProdList
982
Advantage
55
Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.
Tel
027-59420981,18702770802
Fax
027-83322098
Country
China
ProdList
1975
Advantage
50
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8147
Advantage
55
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9767
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9503
Advantage
50
Nanjing XiZe Biotechnology CO., Ltd.
Tel
025-58362220 15250997978
Fax
025-58362220
Email
1511893459@qq.com
Country
China
ProdList
7715
Advantage
55
Zhengzhou KeYulong chemical products Co., Ltd
Tel
17319789407
Fax
0371-53335504
Email
Keyulongchem@163.com
Country
China
ProdList
1993
Advantage
55
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
551-65418679 15837135945
Fax
0551-65418697
Email
info@tnjchem.com
Country
China
ProdList
1889
Advantage
62
Wuhan Bo-Sen Biological Technology Co., Ltd
Tel
027-51335350 15107175693
Fax
027-51335350
Email
bosenyuan@foxmail.com
Country
China
ProdList
192
Advantage
55
Artis Biotech Co. Ltd.
Tel
19138486554 18582380095
Fax
0575-89298961
Email
sales@artisbio.com
Country
China
ProdList
3066
Advantage
58
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
5881
Advantage
65
Boen pharm
Tel
86 512-62572107 62962707
Fax
86 512-62922078
Country
China
ProdList
800
Advantage
58
Shanghai Xilong Biochemical Technology Co., Ltd.
Tel
021-52907766-8042
Fax
021-52906523
Country
China
ProdList
9947
Advantage
58
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9934
Advantage
55
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9604
Advantage
55
More
Less

View Lastest Price from Doxofylline manufacturers

Hebei Dangtong Import and export Co LTD
Product
Doxofylline 69975-86-6
Price
US $54.00-48.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
200Tons
Release date
2023-03-28
Henan Fengda Chemical Co., Ltd
Product
Doxofylline 79975-97-0
Price
US $36.00-1.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-16
Zibo Wei Bin Import & Export Trade Co. Ltd.
Product
Doxofylline 69975-86-6
Price
US $100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10t
Release date
2023-07-04

69975-86-6, DoxofyllineRelated Search:

Dimethyl sulfoxide Purine Dimethyl fumarate alpha-Amylcinnamaldehyde DIOXOPROMETHAZINE HCL Dimethyl ether ETHANE Dihydromyrcenol Aminophylline Dimethyl carbonate 1,4-Dioxane Selenium dioxide N,N-Dimethylformamide TERT-AMYL METHYL ETHER 9-(1,3-Dioxolan-2-ylMethyl)-3,9-dihydro-1,3-diMethyl-1H-purine-2,6-dione 2-Chlorophenyl cyclopentyl ketone 7-(2-HYDROXYETHYL)THEOPHYLLINE DIOXOPROMETHAZINE

  • DOXOFYLLINE
  • DOXOPHYLLINE
  • 2-(7’-teofillinmetil)-1,3-diossolano
  • Doxofyliine
  • 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethyl-purine-2,6-dione
  • DOXOFYLLINE [7-(1,3-DIOXOLAN-2-YLMETHYL)-3,7-DIHYDRO-1,3-DIMETHYL-1H-PURINE-2,6-DIONE]
  • MAXIVENT
  • Ansirnar
  • Doxof3rlline
  • ventax
  • 7-(1,3-dioxolan-2-ylmethyl)-3,7-dihydro-1,3-dimethyl-1h-purine-2,6-dione
  • Dioxyphylline
  • 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethyl-xanthine
  • Doxofylline-d6
  • ABC 1213
  • Doxofylline(ABC 1213)
  • 1H-Purine-2,6-dione,7-(1,3-dioxolan-2-ylMethyl)-3,7-dihydro-1,3-diMethyl-
  • Doxofylline CAS 69975-86-6
  • 7-(1,3-Dioxolan-2-ylmethyl)-1,3-dimethyl-1H-purine-2,6-dione
  • 2-(7’-theophyllinemethyl)-1,3-dioxolane
  • 3,7-dihydro-7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethyl-1h-purine-6-dione
  • 7-(1,3-dioxolan-2-ylmethyl)-theophyllin
  • 7-(1,3-dioxolan-2-ylmethyl)theophylline
  • abc12/3
  • ansimar
  • dioxyfilline
  • Doxofylline Doxofylline
  • Doxofylline&gt
  • 7-((1,3-Dioxolan-2-yl)methyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione
  • Doxofylline USP/EP/BP
  • DoxofyllineQ: What is Doxofylline Q: What is the CAS Number of Doxofylline Q: What is the storage condition of Doxofylline Q: What are the applications of Doxofylline
  • Doxofylline (1225656)
  • Doxofylline API
  • 69975-86-6
  • 79975-97-0
  • 39975-86-6
  • 69975-97-0
  • C7H5O3Cl
  • ZYRTEC
  • Respiratory system
  • 69975-86-6