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Doxofylline

Product Name
Doxofylline
CAS No.
69975-86-6
Chemical Name
Doxofylline
Synonyms
DOXOPHYLLINE;ventax;abc12/3;ansimar;Ansirnar;MAXIVENT;ABC 1213;DOXOFYLLINE;Doxofyliine;Doxof3rlline
CBNumber
CB9265231
Molecular Formula
C11H14N4O4
Formula Weight
266.25
MOL File
69975-86-6.mol
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Doxofylline Property

Melting point:
144-146°C
Boiling point:
409.46°C (rough estimate)
Density 
1.2896 (rough estimate)
refractive index 
1.6000 (estimate)
RTECS 
XH5135000
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
0.42±0.70(Predicted)
color 
White to Off-White
Water Solubility 
Soluble
Merck 
14,3438
InChI
InChI=1S/C11H14N4O4/c1-13-9-8(10(16)14(2)11(13)17)15(6-12-9)5-7-18-3-4-19-7/h6-7H,3-5H2,1-2H3
InChIKey
HWXIGFIVGWUZAO-UHFFFAOYSA-N
SMILES
N1(CC2OCCO2)C2=C(N(C)C(=O)N(C)C2=O)N=C1
CAS DataBase Reference
69975-86-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37
HS Code 
29399990
Toxicity
LD50 in mice (mg/kg): 841 orally; 215.6 i.v.; in rats: 1022.4 orally, 445 i.p. (Franzone)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
D4302
Product name
Doxofylline
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$36
Updated
2024/03/01
TCI Chemical
Product number
D4302
Product name
Doxofylline
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$152
Updated
2024/03/01
Alfa Aesar
Product number
J60575
Product name
Doxofylline
Packaging
5g
Price
$129.65
Updated
2024/03/01
Cayman Chemical
Product number
18746
Product name
Doxofylline
Purity
≥98%
Packaging
1g
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
18746
Product name
Doxofylline
Purity
≥98%
Packaging
5g
Price
$139
Updated
2024/03/01
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Doxofylline Chemical Properties,Usage,Production

Description

Doxofylline, a xanthine bronchodilator related to theophylline, is useful in the treatment of asthma and similar bronchospastic disorders. It has minimal activity on intestinal smooth muscle and the cardiovascular system, and is reportedly devoid of the behavioral effects of theophylline.

Description

Doxofylline is a methylxanthine bronchodilator that has been examined in clinical trials involving patients with either bronchial asthma or chronic obstructive pulmonary disease. Its mechanism of action is related to its ability to inhibit phosphodiesterase activity and, thus, increase cAMP. Compared to other xanthine derivatives, which have direct arrhythmogenic effects, doxofylline demonstrates decreased affinity towards adenosine A1 and A2 receptors, does not interfere with calcium influx into cells, and does not antagonize the action of calcium-channel blockers.

Originator

ABC S.p.A. (Italy)

Uses

Doxofylline is a xanthine molecule that appears to be both bronchodilator and anti-inflammatory with an improved therapeutic window over conventional xanthines such as Theophylline and the evidence supporting the effects of Doxofylline in the treatment of lung diseases.

Uses

H1 antihistamine

Definition

ChEBI: Doxofylline is an oxopurine that is a derivative of xanthine, methylated at N-1 and N-3 and carrying a 1,3-dioxolan-2-ylmethyl group at N-7, used in the treatment of asthma. It has a role as a bronchodilator agent, an antitussive and an anti-asthmatic drug. It is functionally related to a 7H-xanthine.

brand name

Maxivent (Roberts Pharmaceutical);ANSIMAR.

Doxofylline Preparation Products And Raw materials

Raw materials

p-Toluenesulfonic acid Theophylline 3-Chloro-1,2-propanediol

Preparation Products

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Doxofylline Suppliers

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LGM Pharma
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View Lastest Price from Doxofylline manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Doxofylline 69975-86-6
Price
US $100.00-75.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000Ton
Release date
2024-08-13
Hebei Dangtong Import and export Co LTD
Product
Doxofylline 69975-86-6
Price
US $54.00-48.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
200Tons
Release date
2023-03-28
Hebei Weibang Biotechnology Co., Ltd
Product
Doxofylline 69975-86-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-18

69975-86-6, DoxofyllineRelated Search:

Dimethyl sulfoxide Purine Dimethyl fumarate alpha-Amylcinnamaldehyde DIOXOPROMETHAZINE HCL Dimethyl ether ETHANE Dihydromyrcenol Aminophylline Dimethyl carbonate 1,4-Dioxane Selenium dioxide N,N-Dimethylformamide TERT-AMYL METHYL ETHER 9-(1,3-Dioxolan-2-ylMethyl)-3,9-dihydro-1,3-diMethyl-1H-purine-2,6-dione 2-Chlorophenyl cyclopentyl ketone 7-(2-HYDROXYETHYL)THEOPHYLLINE DIOXOPROMETHAZINE

  • DOXOFYLLINE
  • DOXOPHYLLINE
  • 2-(7’-teofillinmetil)-1,3-diossolano
  • Doxofyliine
  • 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethyl-purine-2,6-dione
  • DOXOFYLLINE [7-(1,3-DIOXOLAN-2-YLMETHYL)-3,7-DIHYDRO-1,3-DIMETHYL-1H-PURINE-2,6-DIONE]
  • MAXIVENT
  • Ansirnar
  • Doxof3rlline
  • ventax
  • 7-(1,3-dioxolan-2-ylmethyl)-3,7-dihydro-1,3-dimethyl-1h-purine-2,6-dione
  • Dioxyphylline
  • 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethyl-xanthine
  • Doxofylline-d6
  • ABC 1213
  • Doxofylline(ABC 1213)
  • 1H-Purine-2,6-dione,7-(1,3-dioxolan-2-ylMethyl)-3,7-dihydro-1,3-diMethyl-
  • Doxofylline CAS 69975-86-6
  • 7-(1,3-Dioxolan-2-ylmethyl)-1,3-dimethyl-1H-purine-2,6-dione
  • 2-(7’-theophyllinemethyl)-1,3-dioxolane
  • 3,7-dihydro-7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethyl-1h-purine-6-dione
  • 7-(1,3-dioxolan-2-ylmethyl)-theophyllin
  • 7-(1,3-dioxolan-2-ylmethyl)theophylline
  • abc12/3
  • ansimar
  • dioxyfilline
  • Doxofylline Doxofylline
  • Doxofylline&gt
  • 7-((1,3-Dioxolan-2-yl)methyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione
  • Doxofylline USP/EP/BP
  • DoxofyllineQ: What is Doxofylline Q: What is the CAS Number of Doxofylline Q: What is the storage condition of Doxofylline Q: What are the applications of Doxofylline
  • Doxofylline (1225656)
  • Doxofylline API
  • Doxofylline, 10 mM in DMSO
  • 69975-86-6
  • 79975-97-0
  • 39975-86-6
  • 69975-97-0
  • C7H5O3Cl
  • ZYRTEC
  • Respiratory system
  • 69975-86-6
  • API