Magnolol
Description References- Product Name
- Magnolol
- CAS No.
- 528-43-8
- Chemical Name
- Magnolol
- Synonyms
- 5,5'-Diallyl-[1,1'-biphenyl]-2,2'-diol;Maglol;MAGNOLOL;NSC 293099;HONOKIOL(P);MAGNOLOL(P);Magnolol D6;MAGNOLOL(SH);Magnolol CRS;Magnolol D10
- CBNumber
- CB9265352
- Molecular Formula
- C18H18O2
- Formula Weight
- 266.33
- MOL File
- 528-43-8.mol
Magnolol Property
- Melting point:
- 101.5-102°
- Boiling point:
- 180°C/1mmHg(lit.)
- Density
- 1.107±0.06 g/cm3(Predicted)
- FEMA
- 4559 | MAGNOLOL
- storage temp.
- Sealed in dry,2-8°C
- solubility
- ethanol: soluble1mg/mL
- pka
- 9.49±0.43(Predicted)
- color
- White to Almost white
- Odor
- bitter
- λmax
- 292nm(EtOH)(lit.)
- JECFA Number
- 2023
- Merck
- 14,5697
- Stability:
- Light Sensitive
- LogP
- 4.502 (est)
- CAS DataBase Reference
- 528-43-8(CAS DataBase Reference)
Safety
- Hazard Codes
- N
- Risk Statements
- 37/38-41-51/53
- Safety Statements
- 26-39-61
- RIDADR
- UN 3077
- WGK Germany
- 3
- RTECS
- DV5105500
- HS Code
- 29072990
- Hazardous Substances Data
- 528-43-8(Hazardous Substances Data)
- Toxicity
- LD50 orl-mus: 2200 mg/kg BRXXAA #5135746
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- Y0001289
- Product name
- Magnolol
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0001289
- Price
- $220
- Updated
- 2024/03/01
- Product number
- PHL89317
- Product name
- Magnolol
- Purity
- phyproof? Reference Substance
- Packaging
- 20mg
- Price
- $344
- Updated
- 2024/03/01
- Product number
- M3445
- Product name
- Magnolol
- Purity
- ≥95% (HPLC), from plant
- Packaging
- 10mg
- Price
- $179
- Updated
- 2024/03/01
- Product number
- D3971
- Product name
- 5,5'-Diallyl-2,2'-dihydroxybiphenyl
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $159
- Updated
- 2024/03/01
- Product number
- D3971
- Product name
- 5,5'-Diallyl-2,2'-dihydroxybiphenyl
- Purity
- >98.0%(GC)
- Packaging
- 200mg
- Price
- $54
- Updated
- 2024/03/01
Magnolol Chemical Properties,Usage,Production
Description
Magnolol is an organic compound belonging to lignan. It is a kind of bioactive compounds identified from the bark of the Magnolia officinalis or M. grandiflora. It has been supplemented to Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic disease. It can act on the GABA receptor in vitro as a strong allosteric modulator. It also has antifungal effect, anti- periodontal activity as well as many osteoblast-stimulating and osteoclast-inhibiting activities. It has also found that magnolol can also activate the cannabinoid (CB) receptors.
References
https://en.wikipedia.org/wiki/Magnolol
https://www.caymanchem.com/product/14233
Description
Magnolol is a bioactive compound isolated from the bark of M. officinalis that has been used in Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic diseases. Magnolol can activate cannabinoid (CB) receptors, behaving as a partial agonist with selectivity for the peripheral CB2 subtype (EC50 = 3.28 μM; Ki = 1.44 μM) versus central CB1 (EC50 = 18.3 μM; Ki = 3.15 μM).
Chemical Properties
White or off-white powder
Uses
Magnolol is the bioactive phytochemicals found in Magnolia officinalis (1). Magnolol has been used to treat anxiety, cough, headache and allergies (2). It also inhibits tumor necrosis factor-a-*induced ICAM-1 expression in human lung epithelial cells.
Definition
ChEBI: Magnolol is a member of biphenyls.
Hazard
Moderately toxic by ingestion.
Biological Activity
Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 μM and 17.7 μM, respectively.
Mechanism of action
Magnolol (5,5’-diallyl-2,2’-dihydroxybiphenyl) is a polyphenolic binaphthalene compound and a structural isomer of honokiol. Both magnolol and honokiol are isolated from the stem bark of a traditional Chinese herbal medicine Magnolia officinalis, which has been used for management of nervous disturbance, abdominal distention or disorders, gastrointestinal food stagnancy, and coughing and dyspnea. Magnolol has showed a wide spectrum of beneficial activities, including anti-inflammation, antimicroorganism, antioxidation, antiangiogenesis, anticancer, neuroprotection, cardiovascular protection, and lipolysis activities.
Safety Profile
Moderately toxic by ingestion.When heated to decomposition it emits acrid smoke andirritating vapors.
in vitro
Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. Magnolol preferentially increases (3)H-muscimol binding to hippocampus compared to cortex and cerebellum in vitro. Magnolol has a more potent enhancing effect on GABAA receptor alpha2 subunit. Magnolol shows significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 μg/ml.
in vivo
Magnolol (5-15 mg/kg, p.o.) significantly attenuates the phenotypic severity of dextran sulfate sodium (DSS)-induced colitis in mice. Magnolol (10, 15 mg/kg, p.o.) attenuates histopathological changes and myeloperoxidase activity in the colon of DSS-treated mice, decreases DSS-induced high levels of proinflammatory cytokines TNF-α, IL-1β and IL-6 in the colonic tissues. Magnolol (10 mg/kg, p.o.) also reverses abnormality of serum metabolome, and regulates tryptophan metabolic pathway in mice.
Magnolol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Magnolol manufacturers
- Product
- Magnolol 528-43-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 20kg
- Purity
- 99%
- Supply Ability
- 200000
- Release date
- 2023-08-15
- Product
- magnolia bark extract magnolol 528-43-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 90%; 98% HPLC
- Supply Ability
- 1000kg
- Release date
- 2022-10-10
- Product
- Magnolol 528-43-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000 kg
- Release date
- 2024-04-22