Magnolol

ChemicalBook > CAS DataBase List > Magnolol

Description References

Product Name: Magnolol
CAS No.: 528-43-8
Chemical Name: Magnolol
Synonyms: 5,5'-Diallyl-[1,1'-biphenyl]-2,2'-diol;Maglol;MAGNOLOL;NSC 293099;HONOKIOL(P);MAGNOLOL(P);Magnolol D6;Magnolol-RM;MAGNOLOL(SH);Magnolol CRS
CBNumber: CB9265352
Molecular Formula: C18H18O2
Formula Weight: 266.33
MOL File: 528-43-8.mol

Less

Magnolol Property

Melting point:: 101.5-102°
Boiling point:: 180°C/1mmHg(lit.)
Density: 1.107±0.06 g/cm3(Predicted)
FEMA: 4559 | MAGNOLOL
storage temp.: Sealed in dry,2-8°C
solubility: ethanol: soluble1mg/mL
form: Solid
pka: 9.49±0.43(Predicted)
color: White to Almost white
Odor: bitter
λmax: 292nm(EtOH)(lit.)
JECFA Number: 2023
Merck: 14,5697
Stability:: Light Sensitive
LogP: 4.502 (est)
CAS DataBase Reference: 528-43-8(CAS DataBase Reference)

Less

Safety

Hazard Codes: N
Risk Statements: 37/38-41-51/53
Safety Statements: 26-39-61
RIDADR: UN 3077
WGK Germany: 3
RTECS: DV5105500
HS Code: 29072990
Hazardous Substances Data: 528-43-8(Hazardous Substances Data)
Toxicity: LD50 orl-mus: 2200 mg/kg BRXXAA #5135746

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0001289
Product name: Magnolol
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001289
Price: $220
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHL89317
Product name: Magnolol
Purity: phyproof? Reference Substance
Packaging: 20mg
Price: $344
Updated: 2024/03/01

Sigma-Aldrich

Product number: M3445
Product name: Magnolol
Purity: ≥95% (HPLC), from plant
Packaging: 10mg
Price: $179
Updated: 2024/03/01

TCI Chemical

Product number: D3971
Product name: 5,5'-Diallyl-2,2'-dihydroxybiphenyl
Purity: >98.0%(GC)
Packaging: 1g
Price: $159
Updated: 2024/03/01

TCI Chemical

Product number: D3971
Product name: 5,5'-Diallyl-2,2'-dihydroxybiphenyl
Purity: >98.0%(GC)
Packaging: 200mg
Price: $54
Updated: 2024/03/01

Less

Magnolol Chemical Properties,Usage,Production

Description

Magnolol is an organic compound belonging to lignan. It is a kind of bioactive compounds identified from the bark of the Magnolia officinalis or M. grandiflora. It has been supplemented to Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic disease. It can act on the GABA receptor in vitro as a strong allosteric modulator. It also has antifungal effect, anti- periodontal activity as well as many osteoblast-stimulating and osteoclast-inhibiting activities. It has also found that magnolol can also activate the cannabinoid (CB) receptors.

References

https://en.wikipedia.org/wiki/Magnolol
https://www.caymanchem.com/product/14233

Description

Magnolol is a bioactive compound isolated from the bark of M. officinalis that has been used in Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic diseases. Magnolol can activate cannabinoid (CB) receptors, behaving as a partial agonist with selectivity for the peripheral CB₂ subtype (EC₅₀ = 3.28 μM; K_i = 1.44 μM) versus central CB₁ (EC₅₀ = 18.3 μM; K_i = 3.15 μM).

Chemical Properties

White or off-white powder

Uses

Magnolol is the bioactive phytochemicals found in Magnolia officinalis (1). Magnolol has been used to treat anxiety, cough, headache and allergies (2). It also inhibits tumor necrosis factor-a-*induced ICAM-1 expression in human lung epithelial cells.

Definition

ChEBI: Magnolol is a member of biphenyls.

Hazard

Moderately toxic by ingestion.

Biological Activity

Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 μM and 17.7 μM, respectively.

Mechanism of action

Magnolol (5,5’-diallyl-2,2’-dihydroxybiphenyl) is a polyphenolic binaphthalene compound and a structural isomer of honokiol. Both magnolol and honokiol are isolated from the stem bark of a traditional Chinese herbal medicine Magnolia officinalis, which has been used for management of nervous disturbance, abdominal distention or disorders, gastrointestinal food stagnancy, and coughing and dyspnea. Magnolol has showed a wide spectrum of beneficial activities, including anti-inflammation, antimicroorganism, antioxidation, antiangiogenesis, anticancer, neuroprotection, cardiovascular protection, and lipolysis activities.

Safety Profile

Moderately toxic by ingestion.When heated to decomposition it emits acrid smoke andirritating vapors.

in vitro

Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. Magnolol preferentially increases (3)H-muscimol binding to hippocampus compared to cortex and cerebellum in vitro. Magnolol has a more potent enhancing effect on GABAA receptor alpha2 subunit. Magnolol shows significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 μg/ml.

in vivo

Magnolol (5-15 mg/kg, p.o.) significantly attenuates the phenotypic severity of dextran sulfate sodium (DSS)-induced colitis in mice. Magnolol (10, 15 mg/kg, p.o.) attenuates histopathological changes and myeloperoxidase activity in the colon of DSS-treated mice, decreases DSS-induced high levels of proinflammatory cytokines TNF-α, IL-1β and IL-6 in the colonic tissues. Magnolol (10 mg/kg, p.o.) also reverses abnormality of serum metabolome, and regulates tryptophan metabolic pathway in mice.

Magnolol Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Magnolol Suppliers

Americas 1 Canada 1 China 414 Czech Republic 1 Europe 3 Germany 2 India 5 Japan 3 Poland 1 Switzerland 1 United Kingdom 13 United States 58 Global 503

Tongchuan Boliante Chemical Co. LTD

Tel: 17719597442
Email: 642232259@qq.com
Country: China
ProdList: 92
Advantage: 58

Changsha Staherb Natural Ingredients Co., Ltd.

Tel: 0731-84213302 18374838656
Email: sales06@staherb.cn
Country: China
ProdList: 299
Advantage: 58

Sichuan Hongen Plant Technology Co., Ltd.

Tel: 17340288373
Fax: 86-838-2803556
Email: victor.liu@hovane.com
Country: China
ProdList: 32
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 8418
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18207
Advantage: 66

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11655
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18738
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11707
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Aktin Chemicals, Inc.

Tel: 86-28-85159085
Fax: 86-28-85152372
Email: info@aktinchem.com
Country: China
ProdList: 297
Advantage: 62

Shenzhen Sungening Bio-Tech Co., Ltd

Tel: +86-0755-89668383
Fax: +86-0755-89594066/4038
Email: sales@sungening.com
Country: China
ProdList: 1319
Advantage: 65

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 9387
Advantage: 52

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2862
Advantage: 58

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4727
Advantage: 58

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5653
Advantage: 65

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4940
Advantage: 60

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Chengdu Climax Biotech Co., Ltd.

Tel: 028-83311324 1278112614
Fax: 028-83311324
Email: climaxbiotech@gmail.com
Country: China
ProdList: 925
Advantage: 58

XI'AN KPC-CN BIOLOGICAL TECHNOLOGY CO.,LTD.

Tel: 86-029-85456576
Fax: 86-029-85456576-808
Email: daisy_wang@vip.163.com
Country: China
ProdList: 292
Advantage: 55

Nanjing Spring & Autumn Biological Engineering Co., Ltd.

Tel: 025-84430028 13815430202
Email: sale02@cqherb.com
Country: China
ProdList: 282
Advantage: 59

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9545
Advantage: 55

Shanghai Ruji Biology Technology Co., Ltd.

Tel: +86-21-65211385-8001 36031160
Fax: +86-21-65211385-8004
Email: sales@shruji.com
Country: China
ProdList: 3224
Advantage: 55

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3989
Advantage: 66

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Cheng Du Pufeide Biotechnology Co., Ltd.

Tel: 028-82610909 13388174823
Fax: 8171-1798
Email: scglp@glp-china.com
Country: China
ProdList: 1064
Advantage: 58

Chengdu Herbpurify Co.Ltd.

Tel: 18302802153 18981717076
Fax: 086-28-85377358
Email: 2355253619@qq.com
Country: China
ProdList: 1104
Advantage: 58

Shanghai BeiZhuo Biotech Co., Ltd.

Tel: 021-61119791,13386096464
Fax: 021-50190009
Email: bzswkf@foxmail.com
Country: China
ProdList: 3921
Advantage: 50

Vientiane Tianjin Hengyuan Technology Co., Ltd.

Tel: 15722085254
Fax: 022-26358246
Email: phytochemical@126.com
Country: China
ProdList: 813
Advantage: 55

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9978
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41462
Advantage: 60

Shanghai DiBai Chemicals Co., Ltd.

Tel: 021-54359730 400-008-9730
Fax: 021-54353864
Email: info@chemxyz.com
Country: China
ProdList: 3991
Advantage: 60

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7787
Advantage: 56

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Shanghai Aspire Biological Technology Co., Ltd.

Tel: 021-61317773
Fax: 021-61486878
Email: sales@aspirebio.com
Country: China
ProdList: 2880
Advantage: 58

Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883 15367835770
Fax: 0731-82251112
Email: viola@huatengsci.com
Country: China
ProdList: 5873
Advantage: 58

Shaanxi Pioneer Biotech Co., Ltd.

Tel: 13720616393；029-84385017-8003 13720616393
Fax: 029-84385017
Email: sales@pioneerbiotech.com
Country: China
ProdList: 778
Advantage: 56

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 16166
Advantage: 55

Microherb Inc.

Tel: +86 (744) 832-8128
Fax: QQ:2236179442; Skype:donviez
Email: sales@microherb.cn
Country: China
ProdList: 48
Advantage: 50

Less

View Lastest Price from Magnolol manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.

Product: magnolia bark extract magnolol 528-43-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 90%; 98% HPLC
Supply Ability: 1000kg
Release date: 2022-10-10

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Magnolia Extract 528-43-8
Price: US $120.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-17

Chongqing Zhihe Biopharmaceutical Co., Ltd.

Product: Magnolol 528-43-8
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: ≥99%
Supply Ability: 20tons
Release date: 2024-05-21

528-43-8, MagnololRelated Search:

Allyl chloride Diallylamine Diallyldisulfide Allyl bromide Sodium allylsulfonate Allyl glycidyl ether MAGNOLIABARKEXTRACT Allylamine 2,2'-Biphenol 2-Phenylphenol 3,3'-Dimethylbiphenyl CUPRESSUFLAVONE TRIHYDRATE Honokiol Magnolia bark Extract Honokiol Magnolol 3-(3-Methylphenyl)prop-1-ene 3-ETHYLBIPHENYL Magnolol Bornul magnolol

5,5'-DIALLYL-BIPHENYL-2,2'-DIOL

5,5'-DIALLYL-2,2'-BIPHENYLDIOL

5,5'-DIALLYL-2,2'-DIHYDROXYBIPHENYL

HONOKIOL(P)

MAGNOLOL(SH)

5',5-di-2-propenyl-(1,1'-Biphenyl)-2,2'-diol

MAGNOLOL

Magnolia officinalis Rehd.et Wils

MAGNOLOL 98.0% BY HPLC

Honokiol std.

Magnolol std.

1’-Biphenyl)-2,2’-diol,5’,5-di-2-propenyl-(1

MagnoliaofficinalisRehderetWilson

Nano Liposomal Magnolol

Magnolol, 98%, from Magnolia officinalis Rehder & E. H. Wilson

Magnolol 528-43-8

Magnolol, ≥98%(HPLC)

MAGNOLIABARKEXTRACT

[1,1'-Biphenyl]-2,2'-diol,5,5'-di-2-propenyl-

2,2'-Bichavicol

2,2'-Biphenyldiol, 5,5'-diallyl-

MAGNOLOL(P)

Maglol

Magnolol(2,2 -Bichavicol)

5,5'-Diallyl-[1,1'-biphenyl]-2,2'-diol

4,4'-Diallyl-2,2'-biphenol

Magnolol, froM Houpoea officinalis

[1,1'-Biphenyl]-2,2'-diol, 5,5'-di-2-propen-1-yl-

NSC 293099

4-diphenylphosphoryl-N,N-dimethyl-4,4-diphenyl-1-butanamine

Magnolol 2%-98%

Magnolol CRS

5,5'-Diallyl-2,2'-dihydroxybiphenyl&gt

Magnolol USP/EP/BP

Magnolol D10

Magnolol D6

magnolia bark extract magnolol

Magnolol Powder

5,5'-Diallyl-[1,1'-biphenyl]-2,2'-diol

Magnolol (2,2'-Bichavicol)

Magnolol-RM

528-43-8

5291-75-5

Herb extract

Plant extract

Nutritional Ingredients

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Inhibitors

Honokiol

natural product

Aromatic Phenols

Antifungal

The group of Magnolia