Magnolol

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Description References

Product Name: Magnolol
CAS No.: 528-43-8
Chemical Name: Magnolol
Synonyms: 5,5'-Diallyl-[1,1'-biphenyl]-2,2'-diol;Maglol;MAGNOLOL;NSC 293099;HONOKIOL(P);MAGNOLOL(P);Magnolol D6;MAGNOLOL(SH);Magnolol CRS;Magnolol D10
CBNumber: CB9265352
Molecular Formula: C18H18O2
Formula Weight: 266.33
MOL File: 528-43-8.mol

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Magnolol Property

Melting point:: 101.5-102°
Boiling point:: 180°C/1mmHg(lit.)
Density: 1.107±0.06 g/cm3(Predicted)
FEMA: 4559 | MAGNOLOL
storage temp.: Sealed in dry,2-8°C
solubility: ethanol: soluble1mg/mL
pka: 9.49±0.43(Predicted)
color: White to Almost white
Odor: bitter
λmax: 292nm(EtOH)(lit.)
JECFA Number: 2023
Merck: 14,5697
Stability:: Light Sensitive
LogP: 4.502 (est)
CAS DataBase Reference: 528-43-8(CAS DataBase Reference)

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Safety

Hazard Codes: N
Risk Statements: 37/38-41-51/53
Safety Statements: 26-39-61
RIDADR: UN 3077
WGK Germany: 3
RTECS: DV5105500
HS Code: 29072990
Hazardous Substances Data: 528-43-8(Hazardous Substances Data)
Toxicity: LD50 orl-mus: 2200 mg/kg BRXXAA #5135746

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0001289
Product name: Magnolol
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001289
Price: $220
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHL89317
Product name: Magnolol
Purity: phyproof? Reference Substance
Packaging: 20mg
Price: $344
Updated: 2024/03/01

Sigma-Aldrich

Product number: M3445
Product name: Magnolol
Purity: ≥95% (HPLC), from plant
Packaging: 10mg
Price: $179
Updated: 2024/03/01

TCI Chemical

Product number: D3971
Product name: 5,5'-Diallyl-2,2'-dihydroxybiphenyl
Purity: >98.0%(GC)
Packaging: 1g
Price: $159
Updated: 2024/03/01

TCI Chemical

Product number: D3971
Product name: 5,5'-Diallyl-2,2'-dihydroxybiphenyl
Purity: >98.0%(GC)
Packaging: 200mg
Price: $54
Updated: 2024/03/01

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Magnolol Chemical Properties,Usage,Production

Description

Magnolol is an organic compound belonging to lignan. It is a kind of bioactive compounds identified from the bark of the Magnolia officinalis or M. grandiflora. It has been supplemented to Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic disease. It can act on the GABA receptor in vitro as a strong allosteric modulator. It also has antifungal effect, anti- periodontal activity as well as many osteoblast-stimulating and osteoclast-inhibiting activities. It has also found that magnolol can also activate the cannabinoid (CB) receptors.

References

https://en.wikipedia.org/wiki/Magnolol
https://www.caymanchem.com/product/14233

Description

Magnolol is a bioactive compound isolated from the bark of M. officinalis that has been used in Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic diseases. Magnolol can activate cannabinoid (CB) receptors, behaving as a partial agonist with selectivity for the peripheral CB₂ subtype (EC₅₀ = 3.28 μM; K_i = 1.44 μM) versus central CB₁ (EC₅₀ = 18.3 μM; K_i = 3.15 μM).

Chemical Properties

White or off-white powder

Uses

Magnolol is the bioactive phytochemicals found in Magnolia officinalis (1). Magnolol has been used to treat anxiety, cough, headache and allergies (2). It also inhibits tumor necrosis factor-a-*induced ICAM-1 expression in human lung epithelial cells.

Definition

ChEBI: Magnolol is a member of biphenyls.

Hazard

Moderately toxic by ingestion.

Biological Activity

Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 μM and 17.7 μM, respectively.

Mechanism of action

Magnolol (5,5’-diallyl-2,2’-dihydroxybiphenyl) is a polyphenolic binaphthalene compound and a structural isomer of honokiol. Both magnolol and honokiol are isolated from the stem bark of a traditional Chinese herbal medicine Magnolia officinalis, which has been used for management of nervous disturbance, abdominal distention or disorders, gastrointestinal food stagnancy, and coughing and dyspnea. Magnolol has showed a wide spectrum of beneficial activities, including anti-inflammation, antimicroorganism, antioxidation, antiangiogenesis, anticancer, neuroprotection, cardiovascular protection, and lipolysis activities.

Safety Profile

Moderately toxic by ingestion.When heated to decomposition it emits acrid smoke andirritating vapors.

in vitro

Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. Magnolol preferentially increases (3)H-muscimol binding to hippocampus compared to cortex and cerebellum in vitro. Magnolol has a more potent enhancing effect on GABAA receptor alpha2 subunit. Magnolol shows significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 μg/ml.

in vivo

Magnolol (5-15 mg/kg, p.o.) significantly attenuates the phenotypic severity of dextran sulfate sodium (DSS)-induced colitis in mice. Magnolol (10, 15 mg/kg, p.o.) attenuates histopathological changes and myeloperoxidase activity in the colon of DSS-treated mice, decreases DSS-induced high levels of proinflammatory cytokines TNF-α, IL-1β and IL-6 in the colonic tissues. Magnolol (10 mg/kg, p.o.) also reverses abnormality of serum metabolome, and regulates tryptophan metabolic pathway in mice.

Magnolol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Magnolol manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Magnolia Extract 528-43-8
Price: US $120.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-17

Wuhan Haorong Biotechnology Co.,Ltd

Product: Magnolol 528-43-8
Price: US $0.00-0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 200000
Release date: 2023-08-15

Changsha Staherb Natural Ingredients Co., Ltd.

Product: magnolia bark extract magnolol 528-43-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 90%; 98% HPLC
Supply Ability: 1000kg
Release date: 2022-10-10

528-43-8, MagnololRelated Search:

Allyl chloride Diallylamine Diallyldisulfide Allyl bromide Sodium allylsulfonate Allyl glycidyl ether MAGNOLIABARKEXTRACT Allylamine 2,2'-Biphenol 2-Phenylphenol 3,3'-Dimethylbiphenyl CUPRESSUFLAVONE TRIHYDRATE Honokiol Magnolia bark Extract Honokiol Magnolol 3-(3-Methylphenyl)prop-1-ene 3-ETHYLBIPHENYL Magnolol Bornul magnolol

5,5'-DIALLYL-BIPHENYL-2,2'-DIOL

5,5'-DIALLYL-2,2'-BIPHENYLDIOL

5,5'-DIALLYL-2,2'-DIHYDROXYBIPHENYL

HONOKIOL(P)

MAGNOLOL(SH)

5',5-di-2-propenyl-(1,1'-Biphenyl)-2,2'-diol

MAGNOLOL

Magnolia officinalis Rehd.et Wils

MAGNOLOL 98.0% BY HPLC

Honokiol std.

Magnolol std.

1’-Biphenyl)-2,2’-diol,5’,5-di-2-propenyl-(1

MagnoliaofficinalisRehderetWilson

Nano Liposomal Magnolol

Magnolol, 98%, from Magnolia officinalis Rehder & E. H. Wilson

Magnolol 528-43-8

Magnolol, ≥98%(HPLC)

MAGNOLIABARKEXTRACT

[1,1'-Biphenyl]-2,2'-diol,5,5'-di-2-propenyl-

2,2'-Bichavicol

2,2'-Biphenyldiol, 5,5'-diallyl-

MAGNOLOL(P)

Maglol

Magnolol(2,2 -Bichavicol)

5,5'-Diallyl-[1,1'-biphenyl]-2,2'-diol

4,4'-Diallyl-2,2'-biphenol

Magnolol, froM Houpoea officinalis

[1,1'-Biphenyl]-2,2'-diol, 5,5'-di-2-propen-1-yl-

NSC 293099

4-diphenylphosphoryl-N,N-dimethyl-4,4-diphenyl-1-butanamine

Magnolol 2%-98%

Magnolol CRS

5,5'-Diallyl-2,2'-dihydroxybiphenyl&gt

Magnolol USP/EP/BP

Magnolol D10

Magnolol D6

magnolia bark extract magnolol

Magnolol Powder

5,5'-Diallyl-[1,1'-biphenyl]-2,2'-diol

528-43-8

5291-75-5

Herb extract

Plant extract

Nutritional Ingredients

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Inhibitors

Honokiol

natural product

Aromatic Phenols

Antifungal

The group of Magnolia