ChemicalBook > CAS DataBase List > N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine
N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine
Appearance Uses- Product Name
- N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine
- CAS No.
- 1289942-66-0
- Chemical Name
- N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine
- Synonyms
- EZ-M1;EZLA-M1;Enzalutamide ITS-2;Enzalutamide Impurity N2;N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl];N-[3-fluoro-4-[(MethylaMino)carbonyl]phenyl]-2-Methyl-;N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine;2-[3-fluoro-4-(methylcarbamoyl)anilino]-2-methyl-propanoicaci;2-[3-fluoro-4-(methylcarbamoyl)anilino]-2-methyl-propanoic acid;5. N-[3-Fluoro-4-[(MethylaMino)carbonyl]phenyl]-2-Methylalanine
- CBNumber
- CB92657793
- Molecular Formula
- C12H15FN2O3
- Formula Weight
- 254.26
- MOL File
- 1289942-66-0.mol
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N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine Property
- Boiling point:
- 455℃
- Density
- 1.286
- Flash point:
- 229℃
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 3.59±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C12H15FN2O3/c1-12(2,11(17)18)15-7-4-5-8(9(13)6-7)10(16)14-3/h4-6,15H,1-3H3,(H,14,16)(H,17,18)
- InChIKey
- IAAHEGARPMZSTJ-UHFFFAOYSA-N
- SMILES
- C(O)(=O)[C@](C)(C)NC1=CC=C(C(NC)=O)C(F)=C1
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Safety
- HS Code
- 2921490090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- F599803
- Product name
- 2-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoicacid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
TRC
- Product number
- F599803
- Product name
- 2-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoicacid
- Packaging
- 50mg
- Price
- $120
- Updated
- 2021/12/16
Activate Scientific
- Product number
- AS46673
- Product name
- 2-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid
- Purity
- 97+%
- Packaging
- 1g
- Price
- $68
- Updated
- 2021/12/16
AK Scientific
- Product number
- 3076AH
- Product name
- 2-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoicacid
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-M2260
- Product name
- Alanine,N-[3-fluoro-4-[(methylamino)carbonyl]phenyl]-2-methyl-
- Packaging
- 25g
- Price
- $165
- Updated
- 2021/12/16
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N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine Chemical Properties,Usage,Production
Appearance
N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine is a white to off-white solid.
Uses
N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine is an amino acid derivative and can be used as an intermediate in pharmaceutical synthesis.
Uses
2-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid is an alanine derivative[1].
Synthesis
749927-69-3
62-57-7
1289942-66-0
The general procedure for the synthesis of 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid from 4-bromo-2-fluoro-N-methylbenzamide and 2-aminoisobutyric acid was as follows: 4-bromo-2-fluoro-N-methylbenzamide (10 g, 43.1 mmol), 2-aminoisobutyric acid (6.7 g, 64.7 mmol), potassium carbonate ( 23.8 g, 172.4 mmol) and proline (0.7 g, 4.31 mmol) were added sequentially to a single-neck flask. Subsequently, water (1.8 ml, 100 mmol) was dissolved in DMF (60 ml) and this solution was added to the flask. Under nitrogen protection, CuCl (0.45 g, 4.31 mmol) was added to the reaction mixture, and then the reaction system was heated to 100 °C and the reaction was continuously stirred for 24 hours. After completion of the reaction, the reaction mixture was diluted with water and extracted with dichloromethane. After separation of the organic phase, the pH of the aqueous phase was adjusted to 4 with 1 mol/L citric acid solution, at which point a solid precipitated. The solid was collected by filtration and washed three times with a mixture of water and ethanol (100:1, v/v), resulting in 9.5 g of pure white solid product in 87% yield.
References
[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1111. DOI:10.1080/10408398.2012.708368
N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine manufacturers
Hebei Yanxi Chemical Co., Ltd.
- Product
- N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine 1289942-66-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-19
Henan Fengda Chemical Co., Ltd
- Product
- N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine 1289942-66-0
- Price
- US $10.00-3.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-29
Hebei Miaobian Biotechnology Co., Ltd
- Product
- N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine 1289942-66-0
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99.99
- Supply Ability
- 10Ton
- Release date
- 2021-12-07
1289942-66-0, N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanineRelated Search:
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