6-BroMoquinoline-2-carbaldehyde

Product Name: 6-BroMoquinoline-2-carbaldehyde
CAS No.: 98948-91-5
Chemical Name: 6-BroMoquinoline-2-carbaldehyde
Synonyms: 6-BroMoquinoline-2-carbaldehyde;6-Bromo-2-quinolinecarboxaldehyde;2-Quinolinecarboxaldehyde, 6-bromo-
CBNumber: CB92659878
Molecular Formula: C10H6BrNO
Formula Weight: 236.06
MOL File: 98948-91-5.mol

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6-BroMoquinoline-2-carbaldehyde Property

Boiling point:: 370.7±22.0 °C(Predicted)
Density: 1.632±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 2.85±0.43(Predicted)
Appearance: Light yellow to yellow Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B807875
Product name: 6-Bromoquinoline-2-carboxaldehyde
Packaging: 250mg
Price: $470
Updated: 2021/12/16

Chemenu

Product number: CM227592
Product name: 6-Bromoquinoline-2-carbaldehyde
Purity: 95%
Packaging: 5g
Price: $1130
Updated: 2021/12/16

Labseeker

Product number: SC-68885
Product name: 6-bromoquinoline-2-carbaldehyde
Purity: 95
Packaging: 5g
Price: $1200
Updated: 2021/12/16

Alichem

Product number: 98948915
Product name: 6-Bromoquinoline-2-carbaldehyde
Packaging: 5g
Price: $1257.36
Updated: 2021/12/16

Ambeed

Product number: A128643
Product name: 6-Bromoquinoline-2-carbaldehyde
Purity: 95+%
Packaging: 100mg
Price: $73
Updated: 2021/12/16

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6-BroMoquinoline-2-carbaldehyde Chemical Properties,Usage,Production

Uses

6-Bromoquinoline-2-carboxaldehyde is a reagent used in the synthesis of histone deacetylase (HDAC) inhibitor; an anti-cancer agent.

Synthesis

877-42-9

98948-91-5

At room temperature and under nitrogen protection, 6-bromo-2-methylquinoline (10 g, 45.0 mmol) was dissolved in 1,4-dioxane (100 mL), followed by the addition of selenium dioxide (6.00 g, 54.0 mmol). The reaction mixture was heated to 75°C and maintained at this temperature for 5 hours of reaction. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filter cake was washed with ethyl acetate. The filtrate was concentrated under reduced pressure and the resulting residue was ground with hexane to promote product precipitation. The solid product was collected by vacuum filtration and dried overnight under high vacuum to give the final 6-bromoquinoline-2-carbaldehyde (8.86 g, 37.5 mmol, 83% yield) as an off-white solid. The structure of the product was analyzed by 1H NMR (400 MHz, DMSO-d6) δ 10.11 (d, J=1.0 Hz, 1H), 8.56 (d, J=8.5 Hz, 1H), 8.43 (d, J=2.3 Hz, 1H), 8.14 (d, J=9.0 Hz, 1H), 8.05-8.02 (m, 1H), 8.02-8.00 ( m, 1H) and LCMS (ESI) m/z 235.9,237.9 [M+H]+ (calculated value C10H7BrNO 236.0) confirmed.

References

[1] Patent: WO2011/86469, 2011, A1. Location in patent: Page/Page column 25
[2] Angewandte Chemie - International Edition, 2018, vol. 57, # 35, p. 11374 - 11377
[3] Angew. Chem., 2018, vol. 130, p. 11544 - 11547,4
[4] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0063
[5] Journal of Fluorescence, 2018, vol. 28, # 3, p. 795 - 800

6-BroMoquinoline-2-carbaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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