IKK 16
- Product Name
- IKK 16
- CAS No.
- 873225-46-8
- Chemical Name
- IKK 16
- Synonyms
- CS-1847;IKK Inhibitor;IKK 16 USP/EP/BP;IKK-16(free base);IKK Inhibitor VII;IKK16;IKK-16;IKK INHIBITOR VII;1-[4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]benzoyl]-4-(1-pyrrolidinyl)piperidine;Leucine-rich repeat kinase 2,Inhibitor,IKK 16,LRRK2,inhibit,IKK,I kappa B kinase,IκB kinase;[4-[(4-Benzo[b]thien-2-yl-2-pyriMidinyl)aMino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-Methanone;Methanone, [4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-
- CBNumber
- CB92666638
- Molecular Formula
- C28H29N5OS
- Formula Weight
- 483.63
- MOL File
- 873225-46-8.mol
IKK 16 Property
- storage temp.
- Store at -20°C
- solubility
- ≥23.05 mg/mL in DMSO; ≥11.3 mg/mL in EtOH with ultrasonic; insoluble in H2O
- form
- solid
- color
- White to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B207020
- Product name
- [4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-methanone
- Packaging
- 10mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- B1586
- Product name
- IKK-16(IKKInhibitorVII)
- Packaging
- 10mg
- Price
- $126
- Updated
- 2021/12/16
- Product number
- CS-1282
- Product name
- IKK16
- Purity
- 99.09%
- Packaging
- 10mg
- Price
- $174
- Updated
- 2021/12/16
- Product number
- B1586
- Product name
- IKK-16(IKKInhibitorVII)
- Packaging
- 50mg
- Price
- $494
- Updated
- 2021/12/16
- Product number
- CS-1282
- Product name
- IKK16
- Purity
- 99.09%
- Packaging
- 50mg
- Price
- $714
- Updated
- 2021/12/16
IKK 16 Chemical Properties,Usage,Production
Uses
IKK-16 is a potential novel IκB kinase 2 (IKK2) inhibitor used in the treatment of various immune/inflammatory disorders.
Definition
ChEBI: [4-[[4-(1-benzothiophen-2-yl)-2-pyrimidinyl]amino]phenyl]-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone is a N-acylpiperidine and a member of benzamides.
Biological Activity
ikk-16 (ikk inhibitor vii) is a novel inhibitor of iκb kinase (ikk) with the ic50 values of 0.04μm, 0.2μm and 0.07μm for ikk2, ikk1 and ikk complex, respectively [1].ikk-16 (ikk inhibitor vii) is a 2-benzamido-pyrimidines and selective inhibitor of iκb kinase (ikk). ikk-16 has been reported to effectively inhibit tnfα release into plasma upon lps-challenge in the rat. in addition, ikk-16 has been found to be active at thioglycollate-induced peritonitis model in the mouse. furthermore, ikk-16 has revealed to be an orally bio-available in rats and mice, and have significant in vivo activity in an acute model of cytokine release [1].
target
IKK-2
References
[1] waelchli r1, bollbuck b, bruns c, buhl t, eder j, feifel r, hersperger r, janser p, revesz l, zerwes hg, schlapbach a.design and preparation of 2-benzamido-pyrimidines as inhibitors of ikk. bioorg med chem lett. 2006 jan 1;16(1):108-12. epub 2005 oct 19.
IKK 16 Preparation Products And Raw materials
Raw materials
Preparation Products
IKK 16 Suppliers
- Tel
- --
- Fax
- --
- info@trc-canada.com
- Country
- Canada
- ProdList
- 6038
- Advantage
- 71