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IKK 16

Product Name
IKK 16
CAS No.
873225-46-8
Chemical Name
IKK 16
Synonyms
CS-1847;IKK Inhibitor;IKK 16 USP/EP/BP;IKK-16(free base);IKK Inhibitor VII;IKK 16, 10 mM in DMSO;IKK16;IKK-16;IKK INHIBITOR VII;Abmole M2768-1mg IKK-16 873225-46-8;1-[4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]benzoyl]-4-(1-pyrrolidinyl)piperidine;Leucine-rich repeat kinase 2,Inhibitor,IKK 16,LRRK2,inhibit,IKK,I kappa B kinase,IκB kinase
CBNumber
CB92666638
Molecular Formula
C28H29N5OS
Formula Weight
483.63
MOL File
873225-46-8.mol
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IKK 16 Property

storage temp. 
Store at -20°C
solubility 
≥23.05 mg/mL in DMSO; ≥11.3 mg/mL in EtOH with ultrasonic; insoluble in H2O
form 
solid
color 
White to yellow
InChIKey
BWZJBXAPRCVCKQ-UHFFFAOYSA-N
SMILES
C(C1=CC=C(NC2=NC=CC(C3SC4=CC=CC=C4C=3)=N2)C=C1)(N1CCC(N2CCCC2)CC1)=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1138
Product name
IKK-16 dihydrochloride
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$153
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1138
Product name
IKK-16 dihydrochloride
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$611
Updated
2025/07/31
TRC
Product number
B207020
Product name
[4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-methanone
Packaging
10mg
Price
$185
Updated
2021/12/16
ChemScene
Product number
CS-1282
Product name
IKK16
Purity
99.09%
Packaging
10mg
Price
$174
Updated
2021/12/16
ApexBio Technology
Product number
B1586
Product name
IKK-16(IKKInhibitorVII)
Packaging
10mg
Price
$126
Updated
2021/12/16
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IKK 16 Chemical Properties,Usage,Production

Uses

IKK-16 is a potential novel IκB kinase 2 (IKK2) inhibitor used in the treatment of various immune/inflammatory disorders.

Definition

ChEBI: [4-[[4-(1-benzothiophen-2-yl)-2-pyrimidinyl]amino]phenyl]-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone is a N-acylpiperidine and a member of benzamides.

Biological Activity

ikk-16 (ikk inhibitor vii) is a novel inhibitor of iκb kinase (ikk) with the ic50 values of 0.04μm, 0.2μm and 0.07μm for ikk2, ikk1 and ikk complex, respectively [1].ikk-16 (ikk inhibitor vii) is a 2-benzamido-pyrimidines and selective inhibitor of iκb kinase (ikk). ikk-16 has been reported to effectively inhibit tnfα release into plasma upon lps-challenge in the rat. in addition, ikk-16 has been found to be active at thioglycollate-induced peritonitis model in the mouse. furthermore, ikk-16 has revealed to be an orally bio-available in rats and mice, and have significant in vivo activity in an acute model of cytokine release [1].

in vivo

IKK 16 also demonstrates significant in vivo activity in an acute model of cytokine release. Both routes of administration of IKK 16 (30 mg/kg, sc) or orally (30 mg/kg, p.o) at the indicated dose results in a significant inhibition of 86% (sc) and 75% (p.o.). IKK 16(10 mg/kg, sc) is also active in the thioglycollate-induced peritonitis model in the mouse. The maximal inhibition of neutrophil extravasation in this model is about 50%[1]. Treatment of septic mice with IKK 16 (1 mg/kg body weight i.v.) results in a significantly increased degree of phosphorylation (P<0.05) of serine residues on Akt and eNOS in the liver[3].

target

IKK-2

IC 50

IKK2: 40 nM (IC50); IKK1: 200 nM (IC50); IKK: 70 nM (IC50); LRRK2: 50 nM (IC50)

References

[1] waelchli r1, bollbuck b, bruns c, buhl t, eder j, feifel r, hersperger r, janser p, revesz l, zerwes hg, schlapbach a.design and preparation of 2-benzamido-pyrimidines as inhibitors of ikk. bioorg med chem lett. 2006 jan 1;16(1):108-12. epub 2005 oct 19.

IKK 16 Preparation Products And Raw materials

Raw materials

Preparation Products

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IKK 16 Suppliers

Canada 1 China 88 United Kingdom 1 United States 14 Global 104
Toronto Research Chemicals
Tel
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Fax
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Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
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873225-46-8, IKK 16Related Search:

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  • Methanone, [4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-
  • 1-[4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]benzoyl]-4-(1-pyrrolidinyl)piperidine IKK-16 (IKK Inhibitor VII)
  • 1-[4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]benzoyl]-4-(1-pyrrolidinyl)piperidine
  • IKK16;IKK-16;IKK INHIBITOR VII
  • CS-1847
  • IKK-16(free base)
  • [4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone
  • IKK 16 USP/EP/BP
  • Leucine-rich repeat kinase 2,Inhibitor,IKK 16,LRRK2,inhibit,IKK,I kappa B kinase,IκB kinase
  • (4-((4-(Benzo[b]thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone
  • IKK 16, 10 mM in DMSO
  • Abmole M2768-1mg IKK-16 873225-46-8
  • 873225-46-8
  • NF-kB
  • IκB/IKK
  • Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
  • Inhibitors